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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Biological & Physical Sciences Division (BPS)
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
Ozone high in the stratosphere protects us from the Sun’s ultraviolet light. But ozone near the ground is a pollutant that harms people and plants. The San Joaquin Valley has some of the most polluted air in the country, and NASA scientists with the new Ozone Where We Live (OWWL) project are working to measure ozone and other pollutants there. They need your help!
Do you live or work in Bakersfield, CA? Sign up to host an ozone sensor! It’s like a big lunch box that you place in your yard, but it’s not packed with tuna and crackers. It’s filled with sensors that measure temperature and humidity and sniff out dangerous gases like methane, carbon monoxide, carbon dioxide, and of course, ozone.
Can you fly a plane? Going to the San Joaquin Valley? Sign up to take an ozone sensor on your next flight! You can help measure ozone levels in layers of the atmosphere that are hard for satellites to investigate. Scientists will combine the data you take with data from NASA’s TEMPO satellite to improve air quality models and measurements within the region. Find out more here or email: Emma.l.yates@nasa.gov
Join the Ozone Where We Live (OWWL) project and help NASA scientists protect the people of the San Joaquin Valley! Credit: Emma Yates Share
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Last Updated Jun 24, 2025 Related Terms
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
A collage of artist concepts highlighting the novel approaches proposed by the 2025 NIAC awardees for possible future missions. Through the NASA Innovative Advanced Concepts (NIAC) program, NASA nurtures visionary yet credible concepts that could one day “change the possible” in aerospace, while engaging America’s innovators and entrepreneurs as partners in the journey.
These concepts span various disciplines and aim to advance capabilities such as finding resources on distant planets, making space travel safer and more efficient, and even providing benefits to life here on Earth. The NIAC portfolio of studies also includes several solutions and technologies that could help NASA achieve a future human presence on Mars. One concept at a time, NIAC is taking technology concepts from science fiction to reality.
Breathing beyond Earth
Astronauts have a limited supply of water and oxygen in space, which makes producing and maintaining these resources extremely valuable. One NIAC study investigates a system to separate oxygen and hydrogen gas bubbles in microgravity from water, without touching the water directly. Researchers found the concept can handle power changes, requires less clean water, works in a wide range of temperatures, and is more resistant to bacteria than existing oxygen generation systems for short-term crewed missions. These new developments could make it a great fit for a long trip to Mars.
Newly selected for another phase of study, the team wants to understand how the system will perform over long periods in space and consider ways to simplify the system’s build. They plan to test a large version of the system in microgravity in hopes of proving how it may be a game changer for future missions.
Detoxifying water on Mars
Unlike water on Earth, Mars’ water is contaminated with toxic chemical compounds such as perchlorates and chlorates. These contaminants threaten human health even at tiny concentrations and can easily corrode hardware and equipment. Finding a way to remove contaminates from water will benefit future human explorers and prepare them to live on Mars long term.
Researchers are creating a regenerative perchlorate reduction system that uses perchlorate reduction pathways from naturally occurring bacteria. Perchlorate is a compound comprised of oxygen and chlorine that is typically used for rocket propellant. These perchlorate reduction pathways can be engineered into a type of bacterium that is known for its remarkable resilience, even in the harsh conditions of space. The system would use these enzymes to cause the biochemical reduction of chlorate and perchlorate to chloride and oxygen, eliminating these toxic molecules from the water. With the technology to detoxify water on Mars, humans could thrive on the Red Planet with an abundant water supply.
Tackling deep space radiation exposure
Mitochondria are the small structures within cells often called the “powerhouse,” but what if they could also power human health in space? Chronic radiation exposure is among the many threats to long-term human stays in space, including time spent traveling to and from Mars. One NIAC study explores transplanting new, undamaged mitochondria to radiation-damaged cells and investigates cell responses to relevant radiation levels to simulate deep-space travel. Researchers propose using in vitro human cell models – complex 3D structures grown in a lab to mimic aspects of organs – to demonstrate how targeted mitochondria replacement therapy could regenerate cellular function after acute and long-term radiation exposure.
While still in early stages, the research could help significantly reduce radiation risks for crewed missions to Mars and beyond. Here on Earth, the technology could also help treat a wide variety of age-related degenerative diseases associated with mitochondrial dysfunction.
Suiting up for Mars
Mars is no “walk in the park,” which is why specialized spacesuits are essential for future missions. Engineers propose using a digital template to generate custom, cost-effective, high-performance spacesuits. This spacesuit concept uses something called digital thread technology to protect crewmembers from the extreme Martian environment, while providing the mobility to perform daily Mars exploration endeavors, including scientific excursions.
This now completed NIAC study focused on mapping key spacesuit components and current manufacturing technologies to digital components, identifying technology gaps, benchmarking required capabilities, and developing a conceptional digital thread model for future spacesuit development and operational support. This research could help astronauts suit up for Mars and beyond in a way like never before.
Redefining what’s possible
From studying Mars to researching black holes and monitoring the atmosphere of Venus, NIAC concepts help us push the boundaries of exploration. By collaborating with innovators and entrepreneurs, NASA advances concepts for future and current missions while energizing the space economy.
If you have a visionary idea to share, you can apply to NIAC’s 2026 Phase I solicitation now until July 15.
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Last Updated Jun 23, 2025 EditorLoura Hall Related Terms
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By NASA
NASA, ESA and Jesús Maíz Apellániz (Instituto de Astrofísica de Andalucía, Spain); Acknowledgment: Davide De Martin (ESA/Hubble) Pismis 24, the star cluster seen here in an image released on Dec. 11, 2006, lies within the much larger emission nebula called NGC 6357, located about 8,000 light-years from Earth. The brightest object in the picture was once thought to be a single star with an incredibly large mass of 200 to 300 solar masses. That would have made it by far the most massive known star in the galaxy and would have put it considerably above the currently believed upper mass limit of about 150 solar masses for individual stars. Measurements from NASA’s Hubble Space Telescope, however, discovered that Pismis 24-1 is actually two separate stars, and, in doing so, “halved” their mass to around 100-150 solar masses each.
Image credit: NASA, ESA and Jesús Maíz Apellániz (Instituto de Astrofísica de Andalucía, Spain); Acknowledgment: Davide De Martin (ESA/Hubble)
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By NASA
This NASA/ESA Hubble Space Telescope image features the remote galaxy HerS 020941.1+001557, which appears as a red arc that partially encircles a foreground elliptical galaxy.ESA/Hubble & NASA, H. Nayyeri, L. Marchetti, J. Lowenthal This NASA/ESA Hubble Space Telescope image offers us the chance to see a distant galaxy now some 19.5 billion light-years from Earth (but appearing as it did around 11 billion years ago, when the galaxy was 5.5 billion light-years away and began its trek to us through expanding space). Known as HerS 020941.1+001557, this remote galaxy appears as a red arc partially encircling a foreground elliptical galaxy located some 2.7 billion light-years away. Called SDSS J020941.27+001558.4, the elliptical galaxy appears as a bright dot at the center of the image with a broad haze of stars outward from its core. A third galaxy, called SDSS J020941.23+001600.7, seems to be intersecting part of the curving, red crescent of light created by the distant galaxy.
The alignment of this trio of galaxies creates a type of gravitational lens called an Einstein ring. Gravitational lenses occur when light from a very distant object bends (or is ‘lensed’) around a massive (or ‘lensing’) object located between us and the distant lensed galaxy. When the lensed object and the lensing object align, they create an Einstein ring. Einstein rings can appear as a full or partial circle of light around the foreground lensing object, depending on how precise the alignment is. The effects of this phenomenon are much too subtle to see on a local level but can become clearly observable when dealing with curvatures of light on enormous, astronomical scales.
Gravitational lenses not only bend and distort light from distant objects but magnify it as well. Here we see light from a distant galaxy following the curve of spacetime created by the elliptical galaxy’s mass. As the distant galaxy’s light passes through the gravitational lens, it is magnified and bent into a partial ring around the foreground galaxy, creating a distinctive Einstein ring shape.
The partial Einstein ring in this image is not only beautiful, but noteworthy. A citizen scientist identified this Einstein ring as part of the SPACE WARPS project that asked citizen scientists to search for gravitational lenses in images.
Text Credit: ESA/Hubble
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