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By NASA
CSA (Canadian Space Agency) astronaut Jeremy Hansen, alongside NASA astronauts Victor Glover, Reid Wiseman, and Christina Koch, will launch on the Artemis II mission early next year. The crew will participate in human research studies to provide insights about how the body performs in deep space as part of this mission. Credit: (NASA/James Blair) A sweeping collection of astronaut health studies planned for NASA’s Artemis II mission around the Moon will soon provide agency researchers with a glimpse into how deep space travel influences the human body, mind, and behavior.
During an approximately 10-day mission set to launch in 2026, NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen will collect and store their saliva, don wrist monitors that track movement and sleep, and offer other essential data for NASA’s Human Research Program and other agency science teams.
“The findings are expected to provide vital insights for future missions to destinations beyond low Earth orbit, including Mars,” said Laurie Abadie, an aerospace engineer for the program at NASA’s Johnson Space Center in Houston, who strategizes about how to carry out studies on Artemis missions. “The lessons we learn from this crew will help us to more safely accomplish deep space missions and research,” she said.
One study on the Artemis II mission, titled Immune Biomarkers, will explore how the immune system reacts to spaceflight. Another study, ARCHeR (Artemis Research for Crew Health and Readiness), will evaluate how crew members perform individually and as a team throughout the mission, including how easily they can move around within the confined space of their Orion spacecraft. Astronauts also will collect a standardized set of measurements spanning multiple physiological systems to provide a comprehensive snapshot of how spaceflight affects the human body as part of a third study called Artemis II Standard Measures. What’s more, radiation sensors placed inside the Orion capsule cells will collect additional information about radiation shielding functionality and organ-on-a-chip devices containing astronaut cells will study how deep space travel affects humans at a cellular level.
“Artemis missions present unique opportunities, and challenges, for scientific research,” said Steven Platts, chief scientist for human research at NASA Johnson.
Platts explained the mission will need to protect against challenges including exposure to higher radiation levels than on the International Space Station, since the crew will be farther from Earth.
“Together, these studies will allow scientists to better understand how the immune system performs in deep space, teach us more about astronauts’ overall well-being ahead of a Mars mission, and help scientists develop ways to ensure the health and success of crew members,” he said.
Another challenge is the relatively small quarters. The habitable volume inside Orion is about the size of a studio apartment, whereas the space station is larger than a six-bedroom house with six sleeping quarters, two bathrooms, a gym, and a 360-degree view bay window. That limitation affects everything from exercise equipment selection to how to store saliva samples.
Previous research has shown that spaceflight missions can weaken the immune system, reactivate dormant viruses in astronauts, and put the health of the crew at risk. Saliva samples from space-based missions have enabled scientists to assess various viruses, hormones, and proteins that reveal how well the immune system works throughout the mission.
But refrigeration to store such samples will not be an option on this mission due to limited space. Instead, for the Immune Biomarkers study, crew members will supply liquid saliva on Earth and dry saliva samples in space and on Earth to assess changes over time. The dry sample process involves blotting saliva onto special paper that’s stored in pocket-sized booklets.
“We store the samples in dry conditions before rehydrating and reconstituting them,” said Brian Crucian, an immunologist with NASA Johnson who’s leading the study. After landing, those samples will be analyzed by agency researchers.
For the ARCHeR study, participating crew members will wear movement and sleep monitors, called actigraphy devices, before, during, and after the mission. The monitors will enable crew members and flight controllers in mission control to study real-time health and behavioral information for crew safety, and help scientists study how crew members’ sleep and activity patterns affect overall health and performance. Other data related to cognition, behavior, and team dynamics will also be gathered before and after the mission.
“Artemis missions will be the farthest NASA astronauts have ventured into space since the Apollo era,” said Suzanne Bell, a NASA psychologist based at Johnson who is leading the investigation. “The study will help clarify key mission challenges, how astronauts work as a team and with mission control, and the usability of the new space vehicle system.”
Another human research study, Artemis II Standard Measures, will involve collecting survey and biological data before, during, and after the Artemis II mission, though blood collection will only occur before and after the mission. Collecting dry saliva samples, conducting psychological assessments, and testing head, eye, and body movements will also be part of the work. In addition, tasks will include exiting a capsule and conducting simulated moonwalk activities in a pressurized spacesuit shortly after return to Earth to investigate how quickly astronauts recover their sense of balance following a mission.
Crew members will provide data for these Artemis II health studies beginning about six months before the mission and extending for about a month after they return to Earth.
NASA also plans to use the Artemis II mission to help scientists characterize the radiation environment in deep space. Several CubeSats, shoe-box sized satellites that will be deployed into high-Earth orbit during Orion’s transit to the Moon, will probe the near-Earth and deep space radiation environment. Data gathered by these CubeSats will help scientists understand how best to shield crew and equipment from harmful space radiation at various distances from Earth.
Crew members will also keep dosimeters in their pockets that measure radiation exposure in real time. Two additional radiation-sensing technologies will also be affixed to the inside of the Orion spacecraft. One type of device will monitor the radiation environment at different shielding locations and alert crew if they need to seek shelter, such as during a solar storm. A separate collection of four radiation monitors, enabled through a partnership with the German Space Agency DLR, will be placed at various points around the cabin by the crew after launch to gather further information.
Other technologies also positioned inside the spacecraft will gather information about the potential biological effects of the deep space radiation environment. These will include devices called organ chips that house human cells derived from the Artemis II astronauts, through a project called AVATAR (A Virtual Astronaut Tissue Analog Response). After the Artemis II lands, scientists will analyze how these organ chips responded to deep space radiation and microgravity on a cellular level.
Together, the insights from all the human research science collected through this mission will help keep future crews safe as humanity extends missions to the Moon and ventures onward to Mars.
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NASA’s Human Research Program
NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, commercial missions, the International Space Station and Artemis missions, the program scrutinizes how spaceflight affects human bodies and behaviors. Such research drives the program’s quest to innovate ways that keep astronauts healthy and mission ready as human space exploration expands to the Moon, Mars, and beyond.
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By NASA
Credit: NASA NASA has awarded ASCEND Aerospace & Technology of Cape Canaveral, Florida, the Contract for Organizing Spaceflight Mission Operations and Systems (COSMOS), to provide services at the agency’s Johnson Space Center in Houston.
The COSMOS is a single award, indefinite-delivery/indefinite-quantity contract valued at $1.8 billion that begins its five-year base period no earlier than Dec. 1, with two option periods that could extend until 2034. The Aerodyne Company of Cape Canaveral, Florida, and Jacobs Technology Company of Tullahoma, Tennessee, are joint venture partners.
Work performed under the contract will support NASA’s Flight Operation Directorate including the Orion and Space Launch System Programs, the International Space Station, Commercial Crew Program, and the Artemis campaign. Services include Mission Control Center systems, training systems, mockup environments, and training for astronauts, instructors, and flight controllers.
For more information about NASA and agency programs, visit:
https://www.nasa.gov
-end-
Tiernan Doyle
Headquarters, Washington
202-358-1600
tiernan.doyle@nasa.gov
Chelsey Ballarte
Johnson Space Center, Houston
281-483-5111
chelsey.n.ballarte@nasa.gov
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Last Updated Aug 28, 2025 LocationNASA Headquarters Related Terms
Johnson Space Center Artemis Commercial Crew International Space Station (ISS) ISS Research Johnson Flight Operations Space Launch System (SLS) View the full article
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By NASA
Teresa Sindelar always knew she wanted to be a part of human spaceflight, but she was unsure how to make that dream a reality until a chance encounter with former NASA astronaut Tom Stafford when she was 11 years old.
The pair met in a local jewelry shop near Sindelar’s Nebraska home, where Gen. Stafford was signing autographs. In addition to his photo, Gen. Stafford gave Sindelar a valuable tip – she should check out the Kansas Cosmosphere, a space museum in Hutchinson, Kansas. “I proceeded to attend every camp the Cosmosphere offered as a student, interned during college, and worked there full time while earning my graduate degree,” Sindelar said.
Official portrait of Teresa Sindelar.NASA She discovered a passion for teaching and mentoring young students through her work in the museum’s education department and a stint as a high school science teacher. When she began looking for opportunities at NASA, she sought a position that melded instruction with technical work. “I like pouring into others and watching them grow,” she said.
Today, Sindelar is a chief training officer (CTO) within the Flight Operations Directorate at NASA’s Johnson Space Center in Houston. Along with her fellow CTOs, Sindelar oversees the correct and complete training of NASA astronauts, crew members representing international partners, and all flight controllers. “I put the pieces together,” she said. “It is my job to make sure instructors, schedulers, outside partners, facility managers, and others are all in sync.” She added that CTOs have a unique position because they see the big picture of a training flow and understand the long-term training goals and objectives.
Teresa Sindelar received a 2025 Space Flight Awareness Program Honoree Award, presented by NASA astronaut Randy Bresnik.NASA “I get to do a lot of cool things and go to a lot of cool places,” she said, noting that the training facilities at Johnson and other NASA centers, as well as facilities managed by international partners, are top-notch. While she does enjoy watching astronauts work through problems and learn new systems, she has a special fondness for flight controller training and mentoring young professionals. “What fills my cup the most is seeing a brand-new employee right out of college blossom into a confident flight controller, do their job well, and make our missions better,” she said. “I like knowing that I had something to do with that.”
Sindelar has been part of the Johnson team since 2010 and worked as an educator in what was then called the center’s Office of Education and as a crew training instructor in the Space Medicine Operations Directorate before becoming a CTO. In March 2025, Sindelar received a Space Flight Awareness Program Honoree Award for her outstanding leadership in the Private Astronaut Mission (PAM) program, which is an important component of NASA’s strategy for enabling a robust and competitive commercial economy in low Earth orbit. As the lead CTO for the third PAM, Axiom Mission 3, Sindelar managed training while identifying critical inefficiencies, enhancing mission safety and performance. She spearheaded a key stakeholder retreat to streamline operations, reorganized training resources for improved accessibility, and implemented efficiency improvements that optimized mission support. Sindelar’s work was recognized during an award ceremony at NASA’s Kennedy Space Center in Florida, and she got to attend the launch of NASA’s SpaceX Crew-10 mission as a special guest.
In her 15 years with the agency, she has learned the importance of leading by example. “My team needs to see that I meet the bar I set,” she said. “Leading is about motivating your people so they are committed, not just compliant.”
Teresa Sindelar (front row, third from left) and her Space Medicine Operations crew training team with the crew members of Expedition 48.NASA Keeping a team motivated and on track is particularly important to training success and safety. “We only get a matter of months to train astronauts to do the most hazardous activities that humans have done, or to train flight controllers who literally have the mission and the lives of astronauts in their hands,” Sindelar said, adding that they cannot afford to have an unfocused or indifferent team.
Sindelar observed that Johnson’s training team is acutely aware of their responsibilities. “We live and work in the same communities as the crew members,” she said. “We see them at school functions, at the grocery store, at the park. We know their families are counting on us to bring their loved ones home safely.”
She has also learned that her voice matters. “When I was a young professional, I just never felt I could be influential, but the only person holding me back was me,” she said. “I had to learn to trust in my own instincts. That was definitely outside of my comfort zone.” She credits her mentors with helping her build confidence and knowing when and how to speak up. “I have had many giants of the spaceflight community mold and shape me in my career, from my counselors at the Cosmosphere all the way to flight directors and astronauts,” she said. “It is my privilege to learn from them, and I am grateful to each of them.”
Outside of work, Sindelar uses her voice in a different way – as part of her church choir. She also plays piano, stating that she is as passionate about music and volunteerism as she is about human spaceflight. She is a member of the Friendswood Volunteer Fire Department, as well, serving on its rehab team and as the department’s chaplain
Teresa Sindelar (second from right) and her family with a Friendswood Volunteer Fire Department fire engine. Image courtesy of Teresa Sindelar As NASA prepares to return humans to the Moon and journey on to Mars, Sindelar hopes she has taught the next generation of explorers enough so they can show the world the wonders of the universe. “This next generation will see and do things my generation never even thought of,” she said, adding that it is time for them to start leading. “Use your voice. Take care of each other along the way. Reach out and help the next one in line.”
Sindelar keeps a reminder of that important message on her desk: the picture Gen. Stafford signed all those years ago.
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By NASA
When Michael Ciancone joined NASA in 1983, he could hardly imagine what his 40-plus-year career would entail. From honoring and preserving spaceflight history to advancing safety standards, he has undoubtedly woven his knowledge and experience into NASA’s history as well as its future.
Ciancone currently serves as the Orion Program safety lead, overseeing the Office of Safety and Mission Assurance’s effort to ensure the safety of the Orion crew, vehicle, and associated hardware. In his role, he manages safety reviews of all flight hardware, with a current focus on Artemis II. His everyday success is backed by decades of learning and global collaboration within the areas of human spaceflight safety and history.
Michael Ciancone with Space Shuttle Atlantis at the launch gantry at NASA’s Kennedy Space Center in Florida in 2009. Image courtesy of Michael Ciancone In 1997, Ciancone transferred from NASA’s Glenn Research Center in Cleveland to Johnson Space Center in Houston to serve as the executive officer for the Shuttle/International Space Station Payload Safety Review Panel, as well as group lead for Payload Safety. To better understand the scope and nature of his new role, Ciancone sought opportunities to engage with other safety professionals at conferences and symposia. At the suggestion of his manager, Ciancone instead organized a conference on spaceflight safety for payloads at Johnson, creating a forum for colleagues from the international spaceflight community.
These efforts were the catalyst for the formation of the International Association for the Advancement of Spaceflight Safety (IAASS), an organization founded by Ciancone and Skip Larsen of Johnson along with Alex Soons and Tommaso Sgobba of the European Space Agency. The IAASS is committed to furthering international cooperation and scientific advancements in space system safety and is recognized as the pre-eminent international forum for spaceflight and safety professionals. The organization is responsible for hosting an annual conference, conducting specialized safety training, and publishing seminal books on the aspects of spaceflight safety.
Throughout his tenure, Ciancone has worked closely with colleagues from around the world and he emphasizes that human spaceflight is a global endeavor made possible through respect and collaboration. “[In human spaceflight] there are different and equally valid approaches for achieving a common goal. Successful partnership requires an understanding and respect for the experiences and history of international partners,” he said.
Michael Ciancone (far left) pictured with Spaceflight Safety team members from NASA, the European Space Agency (ESA), and Airbus during a joint NASA/ESA safety review of the European Service Module (ESM) of the Orion Program at the Airbus facility in Bremen, Germany. Image courtesy of Michael Ciancone In addition to his dedication to spaceflight safety, Ciancone is active in the field of spaceflight history. He serves as the chair of the History Committee of the American Astronautical Society and, as a member of the International Academy of Astronautics, he also serves on the History Committee. Working in this community has made Ciancone more keenly aware of dreams of spaceflight as viewed from a historical perspective and guides his daily work at NASA.
Michael Ciancone (left) with Giovanni Caprara, science editor for the Corriere della Sera and co-author of “Early Italian Contributions to Astronautics: From the First Visionary to Construction of the first Italian Liquid Propellant Rocket” during the 75th International Astronautical Congress in Milan, Italy. Image courtesy of Michael Ciancone Beyond his technical achievements, Ciancone has also found creative ways to spice up the spaceflight community. While at Glenn Research Center, he co-founded the NASA Hot Pepper Club—a forum for employees who share a passion for cultivating and consuming hot peppers and pepper products. The club served as a unique space for camaraderie and connection, adding flavor to NASA life.
Ciancone’s immersion in spaceflight history and spaceflight safety has shaped his unique and valuable perspective. In addition to encouraging others to embrace new challenges and opportunities, Ciancone paraphrases Albert Einstein to advise the Artemis Generation to “learn from the past, live in the moment, and dream of the future.” This mentality has enabled him to combine his interest in spaceflight history with his work on Orion over the past 15 years, laying the groundwork for what he refers to as “future history.”
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
In-person participants (L-R) – Back row: Jason Lytle, Stuart Lee, Eric Bershad, Ashot Sargsyan, Aaron Everson, Philip Wells, Sergi Vaquer Araujo, Steven Grover, John A. Heit, Mehdi Shishehbor, Laura Bostick; Middle row: Sarah Childress Taoufik, Stephan Moll, Brandon Macias, Kristin Coffey, Ann-Kathrin Vlacil, Dave Francisco; Front row: James Pavela, Doug Ebert, Kathleen McMonigal, Esther Kim, Emma Hwang; Not pictured: Tyson Brunstetter, J. D. Polk
Online participants: Stephen Alamo, Mark Crowther, Steven Nissen, Mark Rosenberg, Jeffrey Weitz, R. Eugene Zierler, Serena Aunon, Tina Bayuse, Laura Beachy, Becky Brocato, Daniel Buckland, Jackie Charvat, Diana Cruz Topete, Quinn Dufurrena, Robert Haddon, Joanne Kaouk, Kim Lowe, Steve Laurie, Karina Marshall-Goebel, Sara Mason, Shannan Moynihan, James Pattarini, Devan Petersen, Ruth Reitzel, Donna Roberts, Lucia Roccaro, Mike Stenger, Terry Taddeo, Gavin Travers, Mary Van Baalen, Liz WarrenNASA In October 2024, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review the status and progress of research and clinical activities intended to mitigate the risk of venous thromboembolism (VTE) during spaceflight. The working group took place over two days at NASA’s Johnson Space Center; a second meeting on the topic was held in December 2024 at the European Space Agency (ESA) facility in Cologne, Germany.
Read More about the Risk of VTE The working group was assembled from internal NASA subject matter experts (SMEs), the NASA OCHMO Standards Team, NASA and ESA stakeholders, and external SMEs, including physicians and medical professionals from leading universities and medical centers in the United States and Canada.
Background
Spaceflight Venous Thrombosis (SVT)
Spaceflight Venous Thrombosis (SVT) refers to a phenomenon experienced during spaceflight in which a thrombus (blood clot) forms in the internal jugular vein (and/or associated vasculature) that may be symptomatic (thrombus accompanied by, but not limited to, visible internal jugular vein swelling, facial edema beyond “nominal” spaceflight adaptation, eyelid edema, and/or headache) or asymptomatic. Obstructive thrombi have been identified in a very small number of crewmembers, as shown in the figure below.
Note that the figure below is for illustrative purposes only; locations are approximate, and size is not to scale.
Approximate location of identified thrombi in crewmembers.Source: Modified from Cerebral Sinus Venous Thrombosis – University of Colorado Denver With treatment, crewmembers were able to complete their mission, and anticoagulants were discontinued several days prior to landing to minimize the risk of bleeding in the event of a traumatic injury. Some thromboses completely resolved post landing, and some required additional treatment.
Pathophysiology of Venous Thromboembolism (VTE)
The proposed pathogenesis of VTE is referred to as Virchow’s triad and suggests that VTE occurs as the result of:
Alterations in blood flow (i.e., stasis), Vascular endothelial injury/changes, and/or, Alterations in the constituents of the blood leading to hypercoagulability (i.e., hereditary predisposition or acquired hypercoagulability). Note: pathophysiology are the changes that occur during a disease process; hypercoagulability is the increased tendency to develop blood to clots.
The Virchow’s triad of risk factors for venous thrombosis.Bouchnita, 2017 Blood stasis, or venous stasis, refers to a condition in which the blood flow in the veins slows down which leads to pooling in the veins. This slowing of the blood may be due to vein valves becoming damaged or weak, immobility, and/or the absence of muscular contractions. Associated symptoms include swelling, skin changes, varicose veins, and slow-healing sores or ulcers. In terrestrial medicine, venous thrombosis is typically caused by damaged or weakened vein valves, which can be due to many factors, including aging, blood clots, varicose veins, obesity, pregnancy, sedentary lifestyle, estrogen use, and hereditary predisposition.
Spaceflight Considerations
Altered Venous Blood Flow and Spaceflight Associated Neuro-ocular Syndrome
In addition to the terrestrial risk factors of VTE, there are physiological changes associated with spaceflight that are hypothesized to potentially play a role in the development of VTE in weightlessness. Specifically, researchers have explored the effects of the microgravity environment and subsequent observed headward fluid shifts that occur, and the potential impact on blood flow. Crewmembers onboard the International Space Station (ISS) experience weightlessness due to the microgravity environment and thus experience a sustained redistribution of bodily fluids from the legs toward the head. The prolonged headward fluid shifts during weightlessness results in facial puffiness, decreased leg volume, increased cardiac stroke volume, and decreased plasma volume.
Crewmembers have also experienced altered blood flow during spaceflight, including retrograde venous blood flow (RVBF) (the backflow of venous blood towards the brain) or stasis (a stoppage or slowdown in the flow of blood). While the causes of the observed stasis and retrograde blood flow in spaceflight participants is not well understood, the potential clinical significance of the role it may have in the development of thrombus formation warrants further investigation.
Doppler imaging of a retrograde flow in the left internal jugular vein.Yan & Seow, 2009 Other physiological concerns affected by fluid shifts are being studied to consider if any relation to VTE exists. Chronic weightlessness can cause bodily fluids such as blood and cerebrospinal fluid to move toward the head, which can lead to optic nerve swelling, folds in the retina, flattening of the back of the eye, and swelling in the brain. This collection of eye and brain changes is called “spaceflight associated neuro-ocular syndrome,” or SANS. Some astronauts only experience mild changes in space, while others have clinically significant outcomes. The long-term health outcome from these changes is unknown but actively being investigated. The risk of developing SANS is higher during longer-duration missions and remains a top research priority for scientists ahead of a Mars mission.
Conclusions and Further Work
Based on expert opinion and the assessment of the risk factors for thrombosis, an algorithm was developed to provide guidance for in-mission assessment and treatment of thrombus formation in weightlessness. The algorithm is based on early in-flight ultrasound testing to determine the flow characteristic of the left internal jugular vein and associated vasculature.
NASA Working Group Recommendations
The working group recommended several areas for further investigation to assess feasibility and potential to mitigate the risk of thrombosis in spaceflight:
Improved detection capabilities to identify when a thrombus has formed in-flight, Pathophysiology/factors leading to thrombi formation during spaceflight, Countermeasures and treatment
For more information on the working group meeting and a complete list of references, please see the Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report.
Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report Share
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Last Updated Mar 14, 2025 EditorKim Lowe Related Terms
Office of the Chief Health and Medical Officer (OCHMO) Astronauts General Human Health and Performance Humans in Space The Human Body in Space Keep Exploring Discover Related Topics
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