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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The mystery of why life uses molecules with specific orientations has deepened with a NASA-funded discovery that RNA — a key molecule thought to have potentially held the instructions for life before DNA emerged — can favor making the building blocks of proteins in either the left-hand or the right-hand orientation. Resolving this mystery could provide clues to the origin of life. The findings appear in research recently published in Nature Communications.
Proteins are the workhorse molecules of life, used in everything from structures like hair to enzymes (catalysts that speed up or regulate chemical reactions). Just as the 26 letters of the alphabet are arranged in limitless combinations to make words, life uses 20 different amino acid building blocks in a huge variety of arrangements to make millions of different proteins. Some amino acid molecules can be built in two ways, such that mirror-image versions exist, like your hands, and life uses the left-handed variety of these amino acids. Although life based on right-handed amino acids would presumably work fine, the two mirror images are rarely mixed in biology, a characteristic of life called homochirality. It is a mystery to scientists why life chose the left-handed variety over the right-handed one.
A diagram of left-handed and right-handed versions of the amino acid isovaline, found in the Murchison meteorite.NASA DNA (deoxyribonucleic acid) is the molecule that holds the instructions for building and running a living organism. However, DNA is complex and specialized; it “subcontracts” the work of reading the instructions to RNA (ribonucleic acid) molecules and building proteins to ribosome molecules. DNA’s specialization and complexity lead scientists to think that something simpler should have preceded it billions of years ago during the early evolution of life. A leading candidate for this is RNA, which can both store genetic information and build proteins. The hypothesis that RNA may have preceded DNA is called the “RNA world” hypothesis.
If the RNA world proposition is correct, then perhaps something about RNA caused it to favor building left-handed proteins over right-handed ones. However, the new work did not support this idea, deepening the mystery of why life went with left-handed proteins.
The experiment tested RNA molecules that act like enzymes to build proteins, called ribozymes. “The experiment demonstrated that ribozymes can favor either left- or right-handed amino acids, indicating that RNA worlds, in general, would not necessarily have a strong bias for the form of amino acids we observe in biology now,” said Irene Chen, of the University of California, Los Angeles (UCLA) Samueli School of Engineering, corresponding author of the Nature Communications paper.
In the experiment, the researchers simulated what could have been early-Earth conditions of the RNA world. They incubated a solution containing ribozymes and amino acid precursors to see the relative percentages of the right-handed and left-handed amino acid, phenylalanine, that it would help produce. They tested 15 different ribozyme combinations and found that ribozymes can favor either left-handed or right-handed amino acids. This suggested that RNA did not initially have a predisposed chemical bias for one form of amino acids. This lack of preference challenges the notion that early life was predisposed to select left-handed-amino acids, which dominate in modern proteins.
“The findings suggest that life’s eventual homochirality might not be a result of chemical determinism but could have emerged through later evolutionary pressures,” said co-author Alberto Vázquez-Salazar, a UCLA postdoctoral scholar and member of Chen’s research group.
Earth’s prebiotic history lies beyond the oldest part of the fossil record, which has been erased by plate tectonics, the slow churning of Earth’s crust. During that time, the planet was likely bombarded by asteroids, which may have delivered some of life’s building blocks, such as amino acids. In parallel to chemical experiments, other origin-of-life researchers have been looking at molecular evidence from meteorites and asteroids.
“Understanding the chemical properties of life helps us know what to look for in our search for life across the solar system,” said co-author Jason Dworkin, senior scientist for astrobiology at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, and director of Goddard’s Astrobiology Analytical Laboratory.
Dworkin is the project scientist on NASA’s OSIRIS-REx mission, which extracted samples from the asteroid Bennu and delivered them to Earth last year for further study.
“We are analyzing OSIRIS-REx samples for the chirality (handedness) of individual amino acids, and in the future, samples from Mars will also be tested in laboratories for evidence of life including ribozymes and proteins,” said Dworkin.
The research was supported by grants from NASA, the Simons Foundation Collaboration on the Origin of Life, and the National Science Foundation. Vázquez-Salazar acknowledges support through the NASA Postdoctoral Program, which is administered by Oak Ridge Associated Universities under contract with NASA.
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Last Updated Nov 21, 2024 EditorWilliam SteigerwaldContactNancy N. Jonesnancy.n.jones@nasa.govLocationGoddard Space Flight Center Related Terms
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By NASA
5 Min Read Making Mars’ Moons: Supercomputers Offer ‘Disruptive’ New Explanation
A NASA study using a series of supercomputer simulations reveals a potential new solution to a longstanding Martian mystery: How did Mars get its moons? The first step, the findings say, may have involved the destruction of an asteroid.
The research team, led by Jacob Kegerreis, a postdoctoral research scientist at NASA’s Ames Research Center in California’s Silicon Valley, found that an asteroid passing near Mars could have been disrupted – a nice way of saying “ripped apart” – by the Red Planet’s strong gravitational pull.
The team’s simulations show the resulting rocky fragments being strewn into a variety of orbits around Mars. More than half the fragments would have escaped the Mars system, but others would’ve stayed in orbit. Tugged by the gravity of both Mars and the Sun, in the simulations some of the remaining asteroid pieces are set on paths to collide with one another, every encounter further grinding them down and spreading more debris.
Many collisions later, smaller chunks and debris from the former asteroid could have settled into a disk encircling the planet. Over time, some of this material is likely to have clumped together, possibly forming Mars’ two small moons, Phobos and Deimos.
To assess whether this was a realistic chain of events, the research team explored hundreds of different close encounter simulations, varying the asteroid’s size, spin, speed, and distance at its closest approach to the planet. The team used their high-performance, open-source computing code, called SWIFT, and the advanced computing systems at Durham University in the United Kingdom to study in detail both the initial disruption and, using another code, the subsequent orbits of the debris.
In a paper published Nov. 20 in the journal Icarus, the researchers report that, in many of the scenarios, enough asteroid fragments survive and collide in orbit to serve as raw material to form the moons.
“It’s exciting to explore a new option for the making of Phobos and Deimos – the only moons in our solar system that orbit a rocky planet besides Earth’s,” said Kegerreis. “Furthermore, this new model makes different predictions about the moons’ properties that can be tested against the standard ideas for this key event in Mars’ history.”
Two hypotheses for the formation of the Martian moons have led the pack. One proposes that passing asteroids were captured whole by Mars’ gravity, which could explain the moons’ somewhat asteroid-like appearance. The other says that a giant impact on the planet blasted out enough material – a mix of Mars and impactor debris – to form a disk and, ultimately, the moons. Scientists believe a similar process formed Earth’s Moon.
The latter explanation better accounts for the paths the moons travel today – in near-circular orbits that closely align with Mars’ equator. However, a giant impact ejects material into a disk that, mostly, stays close to the planet. And Mars’ moons, especially Deimos, sit quite far away from the planet and probably formed out there, too.
“Our idea allows for a more efficient distribution of moon-making material to the outer regions of the disk,” said Jack Lissauer, a research scientist at Ames and co-author on the paper. “That means a much smaller ‘parent’ asteroid could still deliver enough material to send the moons’ building blocks to the right place.”
It’s exciting to explore a new option for the making of Phobos and Deimos – the only moons in our solar system that orbit a rocky planet besides Earth’s.
Jacob Kegerreis
Postdoctoral research scientist at NASA’s Ames Research Center
Testing different ideas for the formation of Mars’ moons is the primary goal of the upcoming Martian Moons eXploration (MMX) sample return mission led by JAXA (Japan Aerospace Exploration Agency). The spacecraft will survey both moons to determine their origin and collect samples of Phobos to bring to Earth for study. A NASA instrument on board, called MEGANE – short for Mars-moon Exploration with GAmma rays and Neutrons – will identify the chemical elements Phobos is made of and help select sites for the sample collection. Some of the samples will be collected by a pneumatic sampler also provided by NASA as a technology demonstration contribution to the mission. Understanding what the moons are made of is one clue that could help distinguish between the moons having an asteroid origin or a planet-plus-impactor source.
Before scientists can get their hands on a piece of Phobos to analyze, Kegerreis and his team will pick up where they left off demonstrating the formation of a disk that has enough material to make Phobos and Deimos.
“Next, we hope to build on this proof-of-concept project to simulate and study in greater detail the full timeline of formation,” said Vincent Eke, associate professor at the Institute for Computational Cosmology at Durham University and a co-author on the paper. “This will allow us to examine the structure of the disk itself and make more detailed predictions for what the MMX mission could find.”
For Kegerreis, this work is exciting because it also expands our understanding of how moons might be born – even if it turns out that Mars’ own formed by a different route. The simulations offer a fascinating exploration, he says, of the possible outcomes of encounters between objects like asteroids and planets. These events were common in the early solar system, and simulations could help researchers reconstruct the story of how our cosmic backyard evolved.
This research is a collaborative effort between Ames and Durham University, supported by the Institute for Computational Cosmology’s Planetary Giant Impact Research group. The simulations used were run using the open-source SWIFT code, carried out on the DiRAC (Distributed Research Utilizing Advanced Computing) Memory Intensive service (“COSMA”), hosted by Durham University on behalf of the DiRAC High-Performance Computing facility.
For news media:
Members of the news media interested in covering this topic should reach out to the NASA Ames newsroom.
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Last Updated Nov 20, 2024 Related Terms
Mars Ames Research Center Ames Research Center's Science Directorate General High-Tech Computing Mars Moons Martian Moon Exploration (MMX) Missions NASA Centers & Facilities Planets Technology The Solar System Explore More
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By European Space Agency
ESA’s solar eclipse-making Proba-3 mission is about to leave Europe, to head to its launch site in India. The mission’s two spacecraft – which will manoeuvre precisely in Earth orbit so that one casts a shadow onto the other – have departed the facilities of Redwire Space in Kruibeke, Belgium. The pair will be flown to the Satish Dhawan Space Centre, near Chennai, for the launch campaign to begin.
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