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      Students at NASA's Jet Propulsion Laboratory pose for photos around the laboratory wearing their eclipse glasses. Credits: NASA/JPL-Caltech  Recently recognized as the most prestigious internship program by Vault.com, NASA has empowered countless students and early-career professionals to launch careers in science, technology, engineering, and mathematics (STEM) fields. NASA interns make real contributions to space and science missions, making it one of the best places to start your career. 
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      Students congratulate the 23rd astronaut class at NASA’s Johnson Space Center in Houston on March 5, 2024.NASA/Josh Valcarcel Additionally, NASA is recognized as one of America’s Best Employers for Women and one of America’s Best Employers for New Graduates by Forbes, reflecting the agency’s commitment to fostering a diverse and inclusive environment. NASA encourages people from underrepresented groups to apply, creating a diverse cohort of interns who bring a wide range of perspectives and ideas to the agency.  
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      The mystery of why life uses molecules with specific orientations has deepened with a NASA-funded discovery that RNA — a key molecule thought to have potentially held the instructions for life before DNA emerged — can favor making the building blocks of proteins in either the left-hand or the right-hand orientation. Resolving this mystery could provide clues to the origin of life. The findings appear in research recently published in Nature Communications.
      Proteins are the workhorse molecules of life, used in everything from structures like hair to enzymes (catalysts that speed up or regulate chemical reactions). Just as the 26 letters of the alphabet are arranged in limitless combinations to make words, life uses 20 different amino acid building blocks in a huge variety of arrangements to make millions of different proteins. Some amino acid molecules can be built in two ways, such that mirror-image versions exist, like your hands, and life uses the left-handed variety of these amino acids. Although life based on right-handed amino acids would presumably work fine, the two mirror images are rarely mixed in biology, a characteristic of life called homochirality. It is a mystery to scientists why life chose the left-handed variety over the right-handed one.
      A diagram of left-handed and right-handed versions of the amino acid isovaline, found in the Murchison meteorite.NASA DNA (deoxyribonucleic acid) is the molecule that holds the instructions for building and running a living organism. However, DNA is complex and specialized; it “subcontracts” the work of reading the instructions to RNA (ribonucleic acid) molecules and building proteins to ribosome molecules. DNA’s specialization and complexity lead scientists to think that something simpler should have preceded it billions of years ago during the early evolution of life. A leading candidate for this is RNA, which can both store genetic information and build proteins. The hypothesis that RNA may have preceded DNA is called the “RNA world” hypothesis.
      If the RNA world proposition is correct, then perhaps something about RNA caused it to favor building left-handed proteins over right-handed ones. However, the new work did not support this idea, deepening the mystery of why life went with left-handed proteins.
      The experiment tested RNA molecules that act like enzymes to build proteins, called ribozymes. “The experiment demonstrated that ribozymes can favor either left- or right-handed amino acids, indicating that RNA worlds, in general, would not necessarily have a strong bias for the form of amino acids we observe in biology now,” said Irene Chen, of the University of California, Los Angeles (UCLA) Samueli School of Engineering, corresponding author of the Nature Communications paper.
      In the experiment, the researchers simulated what could have been early-Earth conditions of the RNA world. They incubated a solution containing ribozymes and amino acid precursors to see the relative percentages of the right-handed and left-handed amino acid, phenylalanine, that it would help produce. They tested 15 different ribozyme combinations and found that ribozymes can favor either left-handed or right-handed amino acids. This suggested that RNA did not initially have a predisposed chemical bias for one form of amino acids. This lack of preference challenges the notion that early life was predisposed to select left-handed-amino acids, which dominate in modern proteins.
      “The findings suggest that life’s eventual homochirality might not be a result of chemical determinism but could have emerged through later evolutionary pressures,” said co-author Alberto Vázquez-Salazar, a UCLA postdoctoral scholar and member of Chen’s research group.
      Earth’s prebiotic history lies beyond the oldest part of the fossil record, which has been erased by plate tectonics, the slow churning of Earth’s crust. During that time, the planet was likely bombarded by asteroids, which may have delivered some of life’s building blocks, such as amino acids. In parallel to chemical experiments, other origin-of-life researchers have been looking at molecular evidence from meteorites and asteroids.
      “Understanding the chemical properties of life helps us know what to look for in our search for life across the solar system,” said co-author Jason Dworkin, senior scientist for astrobiology at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, and director of Goddard’s Astrobiology Analytical Laboratory.
      Dworkin is the project scientist on NASA’s OSIRIS-REx mission, which extracted samples from the asteroid Bennu and delivered them to Earth last year for further study.
      “We are analyzing OSIRIS-REx samples for the chirality (handedness) of individual amino acids, and in the future, samples from Mars will also be tested in laboratories for evidence of life including ribozymes and proteins,” said Dworkin.
      The research was supported by grants from NASA, the Simons Foundation Collaboration on the Origin of Life, and the National Science Foundation. Vázquez-Salazar acknowledges support through the NASA Postdoctoral Program, which is administered by Oak Ridge Associated Universities under contract with NASA.
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      Last Updated Nov 21, 2024 EditorWilliam SteigerwaldContactNancy N. Jonesnancy.n.jones@nasa.govLocationGoddard Space Flight Center Related Terms
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      It’s exciting to explore a new option for the making of Phobos and Deimos – the only moons in our solar system that orbit a rocky planet besides Earth’s.
      Jacob Kegerreis
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      Testing different ideas for the formation of Mars’ moons is the primary goal of the upcoming Martian Moons eXploration (MMX) sample return mission led by JAXA (Japan Aerospace Exploration Agency). The spacecraft will survey both moons to determine their origin and collect samples of Phobos to bring to Earth for study. A NASA instrument on board, called MEGANE – short for Mars-moon Exploration with GAmma rays and Neutrons – will identify the chemical elements Phobos is made of and help select sites for the sample collection. Some of the samples will be collected by a pneumatic sampler also provided by NASA as a technology demonstration contribution to the mission. Understanding what the moons are made of is one clue that could help distinguish between the moons having an asteroid origin or a planet-plus-impactor source.
      Before scientists can get their hands on a piece of Phobos to analyze, Kegerreis and his team will pick up where they left off demonstrating the formation of a disk that has enough material to make Phobos and Deimos. 
      “Next, we hope to build on this proof-of-concept project to simulate and study in greater detail the full timeline of formation,” said Vincent Eke, associate professor at the Institute for Computational Cosmology at Durham University and a co-author on the paper. “This will allow us to examine the structure of the disk itself and make more detailed predictions for what the MMX mission could find.”  
      For Kegerreis, this work is exciting because it also expands our understanding of how moons might be born – even if it turns out that Mars’ own formed by a different route. The simulations offer a fascinating exploration, he says, of the possible outcomes of encounters between objects like asteroids and planets. These events were common in the early solar system, and simulations could help researchers reconstruct the story of how our cosmic backyard evolved. 
      This research is a collaborative effort between Ames and Durham University, supported by the Institute for Computational Cosmology’s Planetary Giant Impact Research group. The simulations used were run using the open-source SWIFT code, carried out on the DiRAC (Distributed Research Utilizing Advanced Computing) Memory Intensive service (“COSMA”), hosted by Durham University on behalf of the DiRAC High-Performance Computing facility.
      For news media:
      Members of the news media interested in covering this topic should reach out to the NASA Ames newsroom.
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      Last Updated Nov 20, 2024 Related Terms
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