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By NASA
Space-grown crystals could lead to targeted cancer drugs
Researchers used space-grown protein crystals to determine the structure of a helix-loop-helix (HLH) peptide (one with a double helix and connecting loop) in a complex with vascular endothelial growth factor-A (VEGF). VEGF prompts the formation of new blood vessels and inhibiting it can stop tumor growth. This finding suggests that HLH peptides could be used to create drugs to target disease-related proteins like VEGF.
JAXA PCG, an investigation from JAXA (Japan Aerospace Exploration Agency), grew protein crystals in microgravity and returned them to Earth for detailed analysis of their structures. Microgravity enables production of high-quality crystals, and examining their structures supports the design of new drugs and other types of research.
Japan Aerospace Exploration Agency astronaut Soichi Noguchi works on the PCG experiment aboard the International Space Station.NASA Wood could make satellites more sustainable
Wood exposed to space for approximately 10 months showed no change in weight and no erosion due to atomic oxygen. This finding could inform selection of the appropriate species and thickness of wood for use in building satellites.
Metal satellites reentering Earth’s atmosphere can generate particles and aerosols that may harm the ozone layer. Wood becomes water and carbon dioxide on reentry, does not contribute to atmospheric pollution, and could provide a more sustainable option for future space exploration. JAXA’s Exposure of Wood to Outer Space evaluated how atomic oxygen, galactic cosmic rays, and solar energetic particles in space affect the mechanical properties of wood.
Different types of wood to be tested in space as a building material for satellites. Kyoto University Analyzing glass-forming ability of magnesium silicates
Researchers report detailed structural and atomic information for glassy and liquid magnesium silicates, which are important in glass science and geoscience. The results suggest that electronic structure does not play an important role in determining glass-forming ability, but atomic structure does.
JAXA’s Fragility measured thermophysical properties such as density and viscosity of oxidized molten metals using the International Space Station’s Electrostatic Levitation Furnace (ELF) to gain insight into glass formation and the design of novel materials. The ELF makes it possible to observe the behavior of materials without the use of a container, providing information crucial for examining glass formation.
NASA astronaut Scott Kelly works on the Electrostatic Levitation Furnace aboard the International Space Station.NASAView the full article
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By NASA
1 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
Dr. Misty Davies receives the prestigious AIAA Fellowship in May 2024 for her contributions to aerospace safety and autonomous systems, recognized at a ceremony in Washington, DC.NASA In May 2024, Dr. Misty Davies joined the American Institute of Aeronautics and Astronautics (AIAA) Class of 2024 Fellows at a ceremony in Washington, DC. The AIAA website states that, “AIAA confers Fellow upon individuals in recognition of their notable and valuable contributions to the arts, sciences or technology of aeronautics and astronautics.” The first AIAA Fellows were elected in 1934; since then only 2064 people have been selected for the honor. Dr. Davies has focused her career at NASA Ames Research Center on developing tools and techniques that enable the safety assurance of increasingly autonomous systems. She currently serves as the Associate Chief for Aeronautics Systems in the Intelligent Systems Division at NASA Ames and is the Aerospace Operations and Safety Program (AOSP) Technical Advisor for Assurance and Safety. More information on AIAA Fellows is at https://www.aiaa.org/news/news/2024/02/08/aiaa-announces-class-of-2024-honorary-fellows-and-fellows
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By NASA
Anthocyanins protect seeds in space
After exposure to space outside the International Space Station, purple-pigmented rice seeds rich in anthocyanin had higher germination rates than non-pigmented white rice seeds. This result suggests that anthocyanin, a flavonoid known to protect plants from UV irradiation, could help preserve seed viability on future space missions.
Plants are key components for systems being designed to produce nutrients and recycle carbon for future sustained space habitation, but space has been shown to reduce seed viability. Tanpopo-3, part of a series of investigations from JAXA (Japan Aerospace Exploration Agency), examined the role of anthocyanins in maintaining seed viability. Results of this and previous experiments suggest that solar light in space is more detrimental to seeds than radiation.
Preflight image of the Tanpopo panel used to expose seeds and other samples to space. Tanpopo-3 team Low-cost, autonomous technology validated for space research
Researchers verified a pair of devices for conducting experiments in space that have multi-step reactions and require automatic mixing of solutions. This type of low-cost, autonomous technology expands the possibilities for space-based research, including work by commercial entities.
Ice Cubes #6- Kirara, an investigation from ESA (European Space Agency) developed by the Japan Manned Space Systems Corporation, used a temperature-controlled incubator to crystallize proteins in microgravity. The Kirara facility also enables production of polymers, including cellulose, which have different uses than protein crystals. This experiment synthesized and decomposed cellulose.
The Kirara incubator used for experiments in microgravity. United Arab Emirates/Sultan Alneyadi Insights from observations of an X-ray binary star
Researchers used Neutron star Interior Composition Explorer (NICER) to observe the timing of 15 X-ray bursts from 4U 1820–30, an ultracompact X-ray binary (UCXB) star. An X-ray binary is a neutron star orbiting a companion from which it takes matter. If confirmed with future observations, this result makes 4U 1820–30 the fastest-spinning neutron star known in an X-ray binary system and provides insights into the physics of neutron stars.
NICER makes high-precision measurements of neutron stars (the ultra-dense matter created when massive stars explode as supernovas) and other phenomena to increase our understanding of the universe. NICER has monitored 4U 1820–30 since its launch in June 2017. A short orbital period indicates a relatively small binary system, and 4U 1820–30 has the shortest known orbital period among low-mass X-ray binaries.
Animated image of a binary star system,NASA’s Goddard Space Flight Center/Chris SmithView the full article
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By NASA
NASA/Loral O’Hara The Choctaw Heirloom Seeds investigation flew five varieties of heirloom seeds from the Choctaw Nation of Oklahoma aboard the International Space Station in early November 2023. The seeds are Isito (Choctaw Sweet Potato Squash), Tobi (Smith Peas), Tanchi Tohbi (Flour Corn), Tvnishi (Lambsquarter), and Chukfi Peas. The seeds spent six months aboard station, returning to Earth in April 2024.
Next spring, Jones Academy students will plant the space-flown seeds alongside Earth-bound seeds of the same type in the school’s Growing Hope Garden. Students will hypothesize how the seeds will grow and make observations throughout the growing season.
Middle school teachers are developing curriculum incorporating the seeds’ journey to space station and students’ experiments in the garden. This research could impact Native and Indigenous populations across the United States, inviting underrepresented groups to engage with science, technology, engineering, and mathematics.
Image credit: NASA/Loral O’Hara
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By NASA
Researchers demonstrated the feasibility of 3D bioprinting a meniscus or knee cartilage tissue in microgravity. This successful result advances technology for bioprinting tissue to treat musculoskeletal injuries on long-term spaceflight or in extraterrestrial settings where resources and supply capacities are limited.
BFF Meniscus-2 evaluated using the BioFabrication Facility to 3D print knee cartilage tissue using bioinks and cells. The meniscus is the first engineered tissue of an anatomically relevant shape printed on the station. Manufactured human tissues have potential as alternatives to donor organs, which are in short supply. Bioprinting in microgravity overcomes some of the challenges present in Earth’s gravity, such as deformation or collapse of tissue structures.
A human knee meniscus 3D bioprinted in space using the International Space Station’s BioFabrication Facility.Redwire Complex cultures of central nervous system cells known as brain organoids can be maintained in microgravity for long periods of time and show faster development of neurons than cultures on Earth. These findings could help researchers develop treatments for neurodegenerative diseases on Earth and address potential adverse neurological effects of spaceflight.
Cosmic Brain Organoids examined growth and gene expression in 3D organoids created with neural stem cells from individuals with primary progressive multiple sclerosis and Parkinson’s disease. Results could improve understanding of these neurological diseases and support development of new treatments. Researchers plan additional studies on the underlying causes of the accelerated neuron maturation.
Neural growth in brain organoids that spent more than a month in space. Jeanne Frances Loring, National Stem Cell Foundation Researchers demonstrated that induced pluripotent stem cells (iPSCs) can be processed in microgravity using off the-shelf cell culture materials. Using standard laboratory equipment and protocols could reduce costs and make space-based biomedical research accessible to a broader range of scientists and institutions.
Stellar Stem Cells Ax-2 evaluated how microgravity affects methods used to generate and grow stem cells into a variety of tissue types on the ground. iPSCs can give rise to any type of cell or tissue in the human body, and insight into processing in space could support their use in regenerative medicine and future large-scale biomanufacturing of cellular therapeutics in space.
NASA astronaut Peggy Whitson, an Axiom Mission 2 crew member, works on stem cell research on a previous mission. NASA/Shane KimbroughView the full article
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