Jump to content

NASA Identifies Cause of Artemis I Orion Heat Shield Char Loss


Recommended Posts

  • Publishers
Posted
jsc2024e044990~large.jpg?w=1920&h=1280&f
The Artemis II Orion spacecraft is lifted from the Final Assembly and Testing (FAST) Cell and placed in the west altitude chamber inside the Operations and Checkout Building at NASA’S Kennedy Space Center in Florida on June 28, 2024. Inside the altitude chamber, the spacecraft underwent a series of tests simulating deep space vacuum conditions.
Photo Credit: NASA / Rad Sinyak

After extensive analysis and testing, NASA has identified the technical cause of unexpected char loss across the Artemis I Orion spacecraft’s heat shield.

Engineers determined as Orion was returning from its uncrewed mission around the Moon, gases generated inside the heat shield’s ablative outer material called Avcoat were not able to vent and dissipate as expected. This allowed pressure to build up and cracking to occur, causing some charred material to break off in several locations.

“Our early Artemis flights are a test campaign, and the Artemis I test flight gave us an opportunity to check out our systems in the deep space environment before adding crew on future missions,” said Amit Kshatriya, deputy associate administrator, Moon to Mars Program Office, NASA Headquarters in Washington. “The heat shield investigation helped ensure we fully understand the cause and nature of the issue, as well as the risk we are asking our crews to take when they venture to the Moon.”

Findings

Teams took a methodical approach to understanding and identifying the root cause of the char loss issue, including detailed sampling of the Artemis I heat shield, review of imagery and data from sensors on the spacecraft, and comprehensive ground testing and analysis.

During Artemis I, engineers used the skip guidance entry technique to return Orion to Earth. This technique provides more flexibility by extending the range Orion can fly after the point of reentry to a landing spot in the Pacific Ocean. Using this maneuver, Orion dipped into the upper part of Earth’s atmosphere and used atmospheric drag to slow down. Orion then used the aerodynamic lift of the capsule to skip back out of the atmosphere, then reenter for final descent under parachutes to splashdown.

Using Avcoat material response data from Artemis I, the investigation team was able to replicate the Artemis I entry trajectory environment — a key part of understanding the cause of the issue — inside the arc jet facilities at NASA’s Ames Research Center in California. They observed that during the period between dips into the atmosphere, heating rates decreased, and thermal energy accumulated inside the heat shield’s Avcoat material. This led to the accumulation of gases that are part of the expected ablation process. Because the Avcoat did not have “permeability,” internal pressure built up, and led to cracking and uneven shedding of the outer layer.

ksc-20240203-em1-cm-320-0-0001-1.jpeg?w=
After NASA’s Orion spacecraft was recovered at the conclusion of the Artemis I test flight and transported to NASA’s Kennedy Space Center in Florida, its heat shield was removed from the crew module inside the Operations and Checkout Building and rotated for inspection.
Credit: NASA

Teams performed extensive ground testing to replicate the skip phenomenon before Artemis I. However, they tested at much higher heating rates than the spacecraft experienced in flight. The high heating rates tested on the ground allowed the permeable char to form and ablate as expected, releasing the gas pressure. The less severe heating seen during the actual Artemis I reentry slowed down the process of char formation, while still creating gases in the char layer. Gas pressure built up to the point of cracking the Avcoat and releasing parts of the charred layer. Recent enhancements to the arc jet facility have enabled a more accurate reproduction of the Artemis I measured flight environments, so that this cracking behavior could be demonstrated in ground testing.

While Artemis I was uncrewed, flight data showed that had crew been aboard, they would have been safe. The temperature data from the crew module systems inside the cabin were also well within limits and holding steady in the mid-70s Fahrenheit. Thermal performance of the heat shield exceeded expectations.

Engineers understand both the material phenomenon and the environment the materials interact with during entry. By changing the material or the environment, they can predict how the spacecraft will respond. NASA teams unanimously agreed the agency can develop acceptable flight rationale that will keep crew safe using the current Artemis II heat shield with operational changes to entry.

NASA’s Investigation Process

Soon after NASA engineers discovered the condition on the Artemis I heat shield, the agency began an extensive investigation process, which included a multi-disciplinary team of experts in thermal protection systems, aerothermodynamics, thermal testing and analysis, stress analysis, material test and analysis, and many other related technical areas. NASA’s Engineering and Safety Center was also engaged to provide technical expertise including nondestructive evaluation, thermal and structural analysis, fault tree analysis, and other testing support.

“We took our heat shield investigation process extremely seriously with crew safety as the driving force behind the investigation,” said Howard Hu, manager, Orion Program, NASA’s Johnson Space Center in Houston. “The process was extensive. We gave the team the time needed to investigate every possible cause, and they worked tirelessly to ensure we understood the phenomenon and the necessary steps to mitigate this issue for future missions.”

The Artemis I heat shield was heavily instrumented for flight with pressure sensors, strain gauges, and thermocouples at varying ablative material depths. Data from these instruments augmented analysis of physical samples, allowing the team to validate computer models, create environmental reconstructions, provide internal temperature profiles, and give insight into the timing of the char loss.

Approximately 200 Avcoat samples were removed from the Artemis I heat shield at NASA’s Marshall Space Flight Center in Alabama for analysis and inspection. The team performed non-destructive evaluation to “see” inside the heat shield.

One of the most important findings from examining these samples was that local areas of permeable Avcoat, which had been identified prior to the flight, did not experience cracking or char loss. Since these areas were permeable at the start of the entry, the gases produced by ablation were able to adequately vent, eliminating the pressure build up, cracking, and char loss. 

jsc2024e078233.jpg?w=2048
A test block of Avcoat undergoes heat pulse testing inside an arc jet test chamber at NASA’s Ames Research Center in California. The test article, configured with both permeable (upper) and non-permeable (lower) Avcoat sections for comparison, helped to confirm understanding of the root cause of the loss of charred Avcoat material that engineers saw on the Orion spacecraft after the Artemis I test flight beyond the Moon.
Credit: NASA

Engineers performed eight separate post-flight thermal test campaigns to support the root cause analysis, completing 121 individual tests. These tests took place in facilities with unique capabilities across the country, including the Aerodynamic Heating Facility at the Arc-Jet Complex at Ames to test convective heating profiles with various test gases; the Laser Hardened Materials Evaluation Laboratory at Wright‐Patterson Air Force Base in Ohio to test radiative heating profiles and provide real-time radiography; as well as the Interaction Heating Facility at Ames to test combined convective and radiative heating profiles in the air at full-block scale.

Aerothermal experts also completed two hypersonic wind tunnel test campaigns at NASA’s Langley Research Center in Virginia and CUBRC aerodynamic test facilities in Buffalo, New York, to test a variety of char loss configurations and enhance and validate analytical models. Permeability testing was also performed at Kratos in Alabama, the University of Kentucky, and Ames to help further characterize the Avcoat’s elemental volume and porosity. The Advanced Light Source test facility, a U.S. Department of Energy scientific user facility at Lawrence Berkeley National Laboratory, was also used by engineers to examine the heating behavior of the Avcoat at a microstructure level.

In the spring of 2024, NASA stood up an independent review team to conduct an extensive review of the agency’s investigation process, findings, and results. The independent review was led by Paul Hill, a former NASA leader who served as the lead space shuttle flight director for Return to Flight after the Columbia accident, led NASA’s Mission Operations Directorate, and is a current member of the agency’s Aerospace Safety Advisory Panel. The review occurred over a three-month period to assess the heat shield’s post-flight condition, entry environment data, ablator thermal response, and NASA’s investigation progress. The review team agreed with NASA’s findings on the technical cause of the physical behavior of the heat shield.

Heat Shield Advancements

Knowing that permeability of Avcoat is a key parameter to avoid or minimize char loss, NASA has the right information to assure crew safety and improve performance of future Artemis heat shields. Throughout its history, NASA has learned from each of its flights and incorporated improvements into hardware and operations. The data gathered throughout the Artemis I test flight has provided engineers with invaluable information to inform future designs and refinements. Lunar return flight performance data and a robust ground test qualification program improved after the Artemis I flight experience are supporting production enhancements for Orion’s heat shield. Future heat shields for Orion’s return from Artemis lunar landing missions are being produced to achieve uniformity and consistent permeability. The qualification program is currently being completed along with the production of more permeable Avcoat blocks at NASA’s Michoud Assembly Facility in New Orleans.

For more information about NASA’s Artemis campaign, visit:

https://www.nasa.gov/artemis

View the full article

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Similar Topics

    • By NASA
      Credit: NASA NASA has selected Bastion Technologies Inc. of Houston to provide safety and mission assurance services for the agency’s Marshall Space Flight Center in Huntsville, Alabama.
      The Safety and Mission Assurance II (SMAS II) award is a performance-based, indefinite-delivery/indefinite-quantity contract with a maximum potential value of $400 million. A phase-in period begins Monday, followed by a base ordering period of four years with options to extend services through March 2034.
      Under the contract, Bastion will provide services for a wide range of activities including system safety, reliability, maintainability, software assurance, quality engineering and assurance, independent assessment, institutional safety, and pressure systems.
      The work will support various spaceflight and science missions, research and development projects, hardware fabrication and testing, and other activities at NASA Marshall, Michoud Assembly Facility in New Orleans, and Stennis Space Center in Bay St. Louis, Mississippi. Tasks also will be performed at NASA’s Kennedy Space Center in Florida, contractor facilities, and other sites supported by Marshall’s Safety and Mission Assurance Directorate.
      The SMAS II contract is a small business set-aside, which levels the playing field for qualified small businesses to compete for and win federal contracts.
      For information about NASA and agency programs, visit:
      https://www.nasa.gov
      -end-
      Tiernan Doyle
      Headquarters, Washington
      202-358-1600
      tiernan.doyle@nasa.gov
      Molly Porter
      Marshall Space Flight Center, Huntsville, Ala.
      256-424-5158
      molly.a.porter@nasa.gov
      Share
      Details
      Last Updated Sep 15, 2025 LocationNASA Headquarters Related Terms
      Marshall Space Flight Center Kennedy Space Center Michoud Assembly Facility NASA Centers & Facilities Stennis Space Center View the full article
    • By NASA
      4 min read
      Preparations for Next Moonwalk Simulations Underway (and Underwater)
      On Sept. 9, 2025, NASA’s Solar Dynamics Observatory captured this image of the Sun.NASA/GSFC/Solar Dynamics Observatory It looked like the Sun was heading toward a historic lull in activity. That trend flipped in 2008, according to new research.
      The Sun has become increasingly active since 2008, a new NASA study shows. Solar activity is known to fluctuate in cycles of 11 years, but there are longer-term variations that can last decades. Case in point: Since the 1980s, the amount of solar activity had been steadily decreasing all the way up to 2008, when solar activity was the weakest on record. At that point, scientists expected the Sun to be entering a period of historically low activity.
      But then the Sun reversed course and started to become increasingly active, as documented in the study, which appears in The Astrophysical Journal Letters. It’s a trend that researchers said could lead to an uptick in space weather events, such as solar storms, flares, and coronal mass ejections.
      “All signs were pointing to the Sun going into a prolonged phase of low activity,” said Jamie Jasinski of NASA’s Jet Propulsion Laboratory in Southern California, lead author of the new study. “So it was a surprise to see that trend reversed. The Sun is slowly waking up.”
      The earliest recorded tracking of solar activity began in the early 1600s, when astronomers, including Galileo, counted sunspots and documented their changes. Sunspots are cooler, darker regions on the Sun’s surface that are produced by a concentration of magnetic field lines. Areas with sunspots are often associated with higher solar activity, such as solar flares, which are intense bursts of radiation, and coronal mass ejections, which are huge bubbles of plasma that erupt from the Sun’s surface and streak across the solar system.
      NASA scientists track these space weather events because they can affect spacecraft, astronauts’ safety, radio communications, GPS, and even power grids on Earth. Space weather predictions are critical for supporting the spacecraft and astronauts of NASA’s Artemis campaign, as understanding the space environment is a vital part of mitigating astronaut exposure to space radiation.
      Launching no earlier than Sept. 23, NASA’s IMAP (Interstellar Mapping and Acceleration Probe) and Carruthers Geocorona Observatory missions, as well as the National Oceanic and Atmospheric Administration’s SWFO-L1 (Space Weather Follow On-Lagrange 1) mission, will provide new space weather research and observations that will help to drive future efforts at the Moon, Mars, and beyond.
      Solar activity affects the magnetic fields of planets throughout the solar system. As the solar wind — a stream of charged particles flowing from the Sun — and other solar activity increase, the Sun’s influence expands and compresses magnetospheres, which serve as protective bubbles of planets with magnetic cores and magnetic fields, including Earth. These protective bubbles are important for shielding planets from the jets of plasma that stream out from the Sun in the solar wind.
      Over the centuries that people have been studying solar activity, the quietest times were a three-decade stretch from 1645 to 1715 and a four-decade stretch from 1790 to 1830. “We don’t really know why the Sun went through a 40-year minimum starting in 1790,” Jasinski said. “The longer-term trends are a lot less predictable and are something we don’t completely understand yet.”
      In the two-and-a-half decades leading up to 2008, sunspots and the solar wind decreased so much that researchers expected the “deep solar minimum” of 2008 to mark the start of a new historic low-activity time in the Sun’s recent history.
      “But then the trend of declining solar wind ended, and since then plasma and magnetic field parameters have steadily been increasing,” said Jasinski, who led the analysis of heliospheric data publicly available in a platform called OMNIWeb Plus, run by NASA’s Goddard Space Flight Center in Greenbelt, Maryland.
      The data Jasinski and colleagues mined for the study came from a broad collection of NASA missions. Two primary sources — ACE (Advanced Composition Explorer) and the Wind mission — launched in the 1990s and have been providing data on solar activity like plasma and energetic particles flowing from the Sun toward Earth. The spacecraft belong to a fleet of NASA Heliophysics Division missions designed to study the Sun’s influence on space, Earth, and other planets.
      News Media Contacts
      Gretchen McCartney
      Jet Propulsion Laboratory, Pasadena, Calif.
      818-287-4115
      gretchen.p.mccartney@jpl.nasa.gov 
      Karen Fox / Abbey Interrante
      NASA Headquarters, Washington
      202-358-1600
      karen.c.fox@nasa.gov / abbey.a.interrante@nasa.gov
      2025-118
      Share
      Details
      Last Updated Sep 15, 2025 Related Terms
      Heliophysics Jet Propulsion Laboratory The Solar System Explore More
      3 min read Weird Ways to Observe the Moon
      International Observe the Moon Night is on October 4, 2025, this year– but you can observe…
      Article 8 hours ago 5 min read NASA’s GUARDIAN Tsunami Detection Tech Catches Wave in Real Time
      Article 3 days ago 5 min read New U.S.-European Sea Level Satellite Will Help Safeguard Ships at Sea
      Article 4 days ago Keep Exploring Discover Related Topics
      Missions
      Humans in Space
      Climate Change
      Solar System
      View the full article
    • By NASA
      One of the challenges many teachers face year after year is a sense of working alone. Despite the constant interaction with students many questions often linger: Did the lesson stick? Will students carry this knowledge with them? Will it shape how they see and engage with the world? What can be easy to overlook is that teaching does not happen in isolation. Each classroom, or any other educational setting, is part of a much larger journey that learners travel. This journey extends through a network of educators, where each experience can build on the last. These interconnected networks, known as Connected Learning Ecosystems (CLEs), exist wherever learning happens. At their core, CLEs are the collective of people who contribute to a young person’s growth and education over time.
      Educators at the August 2025 Connected Learning Ecosystems Gathering in Orono, ME engaged in discussion around using NASA data in their learning contexts. Recognizing this, NASA’s Science Activation Program launched the Learning Ecosystems Northeast (LENE) project to strengthen and connect regional educator networks across Maine and the broader Northeast. With a shared focus on Science, Technology, Engineering, and Mathematics (STEM), LENE brings together teachers, librarians, 4-H mentors, land trust educators, and many others committed to expanding scientific understanding, deepening data literacy, and preparing youth to navigate a changing planet. To support this work, LENE hosts biannual Connected Learning Ecosystem Gatherings. These multi-day events bring educators together to share progress, celebrate achievements, and plan future collaborations. More than networking, these gatherings reinforce the collective impact educators have, ensuring that their efforts resonate far beyond individual classrooms and enrich the lives of the learners they guide.
      “I am inspired by the GMRI staff and participants. I never expected to get to do climate resilience-related work in my current job as a children’s librarian. I am excited to do meaningful and impactful work with what I gain from being part of this the LENE community. This was a very well-run event! Thank you to all!” -anonymous


      This year’s Gathering took place August 12 and 13, 2025, in Orono, ME at the University of Maine (a LENE project partner). Nearly 70 educators from across the northeast came together for two amazingly energized days of connection, learning, and future planning. While each event is special, this summer’s Gathering was even more remarkable due to the fact that for, the first time, each workshop was led by an established LENE educator. Either by self-nomination or request from leadership (requiring little convincing), every learning experience shared over the conference days was guided by the thoughtful investigation and real life application of LENE Project Partners, CLE Lead Educators, and community collaborators.
      Brian Fitzgerald and Jackie Bellefontaine from the Mount Washington Observatory in New Hampshire, a LENE Project Partner, led the group through a hands-on activity using NASA data and local examples to observe extreme weather. Librarian Kara Reiman guided everyone through the creation and use of a newly established Severe Weather Disaster Prep Kit, including games and tools to manage climate anxiety. Katrina Heimbach, a long time CLE constituent from Western Maine taught how to interpret local data using a creative and fun weaving technique. Because of the established relationship between Learning Ecosystems Northeast and the University of Maine, attendees to the Gathering were able to experience a guided tour through the Advanced Structures and Composites Center and one of its creations, the BioHome3D – the world’s first 3D printed house made entirely with forest-derived, recyclable materials.
      Two full days of teachers leading teachers left the entire group feeling energized and encouraged, connected, and centered. The increased confidence in their practices gained by sustained support from their peers allowed these educators to step up and share – embodying the role of Subject Matter Expert. Seeing their colleagues take center stage makes it easier for other educators to envision themselves in similar roles and provides clear guidance on how to take those steps themselves. One educator shared their thoughts following the experience:
      “This was my first time attending the LENE conference, and I was immediately welcomed and made to feel ‘part of it all’. I made connections with many of the educators who were present, as well as the LENE staff and facilitators. I hope to connect with my new CLE mates in the near future!” Another participant reported, “I am inspired by the … staff and participants. I never expected to get to do climate resilience-related work in my current job as a children’s librarian. I am excited to do meaningful and impactful work with what I gain from being part of the LENE community. This was a very well-run event! Thank you to all!”
      Even with the backing of regional groups, many educators, especially those in rural communities, still struggle with a sense of isolation. The biannual gatherings play an important role in countering that, highlighting the fact that this work is unfolding across the state. Through Connected Learning Ecosystems, educators are able to build and reinforce networks that help close the gaps created by distance and geography.
      These Gatherings are part of ongoing programming organized by Learning Ecosystems Northeast, based at the Gulf of Maine Research Institute, that fosters peer communities across the Northeast, through which teachers, librarians, and out-of-school educators can collaborate to expand opportunities for youth to engage in data-driven investigations and integrate in- and out-of-school learning. Learn more about Learning Ecosystems Northeast’s efforts to empower the next generation of environmental stewards: https://www.learningecosystemsnortheast.org.
      The Learning Ecosystems Northeast project is supported by NASA under cooperative agreement award number NNX16AB94A and is part of NASA’s Science Activation Portfolio. Learn more about how Science Activation connects NASA science experts, real content, and experiences with community leaders to do science in ways that activate minds and promote deeper understanding of our world and beyond: https://science.nasa.gov/learn/about-science-activation/.
      Share








      Details
      Last Updated Sep 15, 2025 Related Terms
      Earth Science Science Activation Explore More
      13 min read The Earth Observer Editor’s Corner: July–September 2025


      Article


      5 days ago
      21 min read Summary of the 11th ABoVE Science Team Meeting


      Article


      5 days ago
      5 min read From NASA Citizen Scientist to Astronaut Training: An Interview with Benedetta Facini


      Article


      3 weeks ago
      View the full article
    • By NASA
      NASA/Michael DeMocker NASA astronauts Matthew Dominick (left) and Mark Vande Hei (right) prepare to fly out to a landing zone in the Rocky Mountains as part of the certification run for the NASA Artemis course on Aug. 26, 2025. The mountains in northern Colorado offer similar visual illusions and flight environments to the Moon.
      The newly certified lander flight training course marks a key milestone in crew training for Artemis missions to the Moon. Through Artemis, NASA will explore the lunar South Pole, paving the way for human exploration farther into the solar system, including Mars.
      Learn more about the training course.
      Image credit: NASA/Michael DeMocker
      View the full article
    • By NASA
      5 min read
      Avatars for Astronaut Health to Fly on NASA’s Artemis II
      An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
      The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond. 
      AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
      Nicky Fox
      Associate Administrator, NASA Science Mission Directorate
      “AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
      The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
      Organ-on-a-chip: mimic for human health
      Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs. 
      Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
      Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
      Bone marrow as bellwether
      The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
      Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
      Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
      To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
      Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
      Passenger for research
      “For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
      During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
      For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
      Lisa Carnell
      Director of NASA’s Biological and Physical Sciences Division
      Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
      Keep Exploring BPS Scientific Goals
      Goals



      Precision Health



      AVATAR



      Quantum Leaps


      Biological & Physical Sciences Division (BPS)

      NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
      View the full article
  • Check out these Videos

×
×
  • Create New...