Jump to content

Tissue Chips Accurately Model Organs in Space


NASA

Recommended Posts

  • Publishers
In an image taken from inside an enclosed glovebox aboard the International Space Station, a structure with orange-brown sides and a green top floats inside the glovebox in the center of the image. The box has several stickers with labels. To the right, NASA astronaut Jessica Meir can be seen through the clear side of the glovebox wearing a headset and smiling as she looks at the camera.
NASA astronaut Jessica Meir conducts cardiac research using tissue chip platforms in the Life Sciences Glovebox aboard space station in March of 2022.
NASA

The International Space Station offers a unique microgravity environment where cells outside the human body behave similarly to how they do inside the human body. Tissue chips are small devices containing living cells that mimic complex functions of specific human tissues and organs. Researchers can run experiments using tissue chips aboard space station to understand disease progression and provide faster and safer alternatives for preparing medicine for clinical trials.

Researchers placed engineered heart tissues on tissue chips sent to study how microgravity impacts cardiac functions in space. Data collected by the chips showed these heart tissues experienced impaired contractions, subcellular structural changes, and increased stress, which can lead to tissue damage and disease. Previous studies conducted on human subjects have displayed similar outcomes. In the future, engineered heart tissues could accurately model the effects of spaceflight on cardiac function.

Another investigation used muscle-on-a-chip technology to evaluate whether engineered muscle tissues can mimic the characteristics of reduced muscle regeneration in microgravity. Researchers found that engineered muscle-on-a-chip platforms are viable for studying muscle-related bioprocesses in space. In addition, samples treated with drugs known to stimulate muscle regeneration showed partial prevention of the effects of microgravity. These results demonstrate that muscle-on-chip can also be used to study and identify drugs that may prevent muscle decline in space and age-related muscle decline on Earth.

NASA astronaut Megan McArthur’s hands are shown wearing blue medical gloves. In front of her hands is a CD-sized black structure with orange circles.
NASA astronaut Megan McArthur works on the Cardinal Muscle investigation in the Life Sciences Glovebox aboard the space station in August of 2021.
NASA

View the full article

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Similar Topics

    • By European Space Agency
      At the International Astronautical Congress (IAC) in Milan this week, ESA signed a contract for Element #1, the first phase of the HydRON Demonstration System. HydRON, which stands for High thRoughput Optical Network, is set to transform the way data-collecting satellites communicate, using laser technology that will allow satellites to connect with each other and ground networks much faster.
      View the full article
    • By Space Force
      The multinational named operation represents a growing commitment among the closest allies in space to jointly strengthen defenses and deter aggression, ensuring space remains a domain that benefits all of humanity.

      View the full article
    • By NASA
      4 min read
      Preparations for Next Moonwalk Simulations Underway (and Underwater)
      Science in Space: October 2024
      Cultures around the world celebrate Halloween on Oct 31. In many places, in addition to people wearing costumes and eating candy, this day is associated with spooky decorating using fake blood, skeletons, flies, and spiders, some of them glow-in-the-dark.
      Crew members on the International Space Station have been known to indulge in a bit of dressing up and candy consumption to mark the day, and the research they conduct year-round occasionally involves these iconic Halloween themes. No tricks, just treats.
      JAXA astronaut Koichi Wakata and NASA astronauts Frank Rubio, Nicole Mann, and Josh Cassada dressed up for Halloween 2022.NASA A current investigation, Megakaryocytes Flying-One or MeF1, investigates how components of real blood known as megakaryocytes and platelets develop and function during spaceflight. Megakaryocytes are large cells found in bone marrow and platelets are pieces of these cells. Both play important roles in blood clotting and immune response. Results could improve understanding of changes in inflammation, immune responses, and clot formation in spaceflight and on the ground.
      Creepy crawlies
      Fake spiders and flies are popular Halloween decorations (and fodder for fun pranks). Several investigations on the space station have used real ones.
      Fruit Fly Lab-02 used fruit flies, Drosophila melanogaster, to examine the cellular and genetic mechanisms that affect heart health during spaceflight. The flies experienced several effects on cardiac function, including changes in muscle fibers, that could be a fundamental response of heart muscles to microgravity.
      MVP Fly-01 looked at how spaceflight affects immune function and resulting changes to the nervous system of the same type of flies, along with the value of artificial gravity as a countermeasure. Researchers found that artificial gravity provided some protection to physical changes to the central nervous system from spaceflight. Spiders, Fruit Flies and Directional Plant Growth (CSI-05) compared the weaving characteristics of golden orb-web spiders on the space station and the ground. Under natural conditions, the spiders build asymmetric webs with the hub near the upper edge, where they wait for prey. In microgravity, most but not all webs were quite symmetric, although webs built when the lights were on were more asymmetric and the spiders waited facing away from the lights. This could mean that in the absence of gravity, the spiders orient to the direction of light.
      A golden-orb weaver and its web on the space station.NASA Bad to the bones
      Everyone needs healthy bones and skeletons, and not just on Halloween. But spaceflight and aging on Earth can cause loss of bone mass. Space station research has looked at the mechanisms behind this loss as well as countermeasures such as exercise and nutrition.
      Bisphosphonates as a Countermeasure to Bone Loss examined whether a medication that blocks the breakdown of bone, in conjunction with the routine in-flight exercise program, protected crew members from bone mineral density loss during spaceflight. The research found that it did reduce loss, which in turn reduced the occurrence of kidney stones in crew members.
      Assessment of the Effect of Space Flight on Bone (TBone) studied how spaceflight affects bone quality using a high-resolution bone scan technique. Researchers found incomplete recovery of bone strength and density in the tibia (a bone in the lower leg), comparable to a decade or more of terrestrial age-related bone loss. The work also highlighted the relationship between length of a mission and bone loss and suggested that pre-flight markers could identify crew members at greatest risk.
      In a merging of blood and bones, CSA’s Marrow looked at whether microgravity has a negative effect on bone marrow and the blood cells it produces. Decreased production of red blood cells can lead to a condition called space anemia. Findings related to the expression of genes involved in red blood cell formation and those related to bone marrow adipose or fat tissue, which stores energy and plays a role in immune function, could contribute to development of countermeasures. Marrow results also suggested that the destruction of red blood cells (known as hemolysis) is a primary effect of spaceflight and contributes to anemia. Bad news for vampires.
      ESA astronaut Thomas Pesquet storing Marrow samples in MELFI.NASA It glows in the dark
      Fluorescence – a cool effect at a ghoulish party – also is a common tool in scientific research, enabling researchers to see physical and genetic changes. The space station has special microscopes for observing glow-in-the-dark samples.
      For Medaka Osteoclast 2, an investigation from JAXA (Japan Aerospace Exploration Agency), researchers genetically modified translucent Medaka fish with fluorescent proteins to help them observe cellular and genetic changes the fish experience during spaceflight. One analysis revealed a decrease in the mineral density of bones in the throat and provided insights into the mechanisms behind these changes.
      A translucent Medaka fish with fluorescent proteins showing its bone structure.Philipp Keller, Stelzer Group, EMBL Biorock, an investigation from ESA (European Space Agency), examined how microgravity affects the interaction between rocks and microbes and found little effect on microbial growth. This result suggests that microbial-supported bioproduction and life support systems can perform in reduced gravity such as that on Mars, which would be a perfect place for an epic Halloween celebration.
      Preflight fluorescence microscopy image of a biofilm for the Biorock experiment.NASA Keep Exploring Discover More Topics From NASA
      International Space Station
      Space Station Research and Technology
      Space Station Research Results
      Station Benefits for Humanity
      View the full article
    • By Space Force
      U.S. Space Command formally recognized Germany’s membership in Multinational Force-Operation Olympic Defender.

      View the full article
    • By European Space Agency
      Image: Resembling a Martian-like surface, this Copernicus Sentinel-2 image shows part of the Hardap region in south-central Namibia on the western edge of the Kalahari Desert. View the full article
  • Check out these Videos

×
×
  • Create New...