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    • By NASA
      Researchers demonstrated the feasibility of 3D bioprinting a meniscus or knee cartilage tissue in microgravity. This successful result advances technology for bioprinting tissue to treat musculoskeletal injuries on long-term spaceflight or in extraterrestrial settings where resources and supply capacities are limited.

      BFF Meniscus-2 evaluated using the BioFabrication Facility to 3D print knee cartilage tissue using bioinks and cells. The meniscus is the first engineered tissue of an anatomically relevant shape printed on the station. Manufactured human tissues have potential as alternatives to donor organs, which are in short supply. Bioprinting in microgravity overcomes some of the challenges present in Earth’s gravity, such as deformation or collapse of tissue structures.
      A human knee meniscus 3D bioprinted in space using the International Space Station’s BioFabrication Facility.Redwire Complex cultures of central nervous system cells known as brain organoids can be maintained in microgravity for long periods of time and show faster development of neurons than cultures on Earth. These findings could help researchers develop treatments for neurodegenerative diseases on Earth and address potential adverse neurological effects of spaceflight.

      Cosmic Brain Organoids examined growth and gene expression in 3D organoids created with neural stem cells from individuals with primary progressive multiple sclerosis and Parkinson’s disease. Results could improve understanding of these neurological diseases and support development of new treatments. Researchers plan additional studies on the underlying causes of the accelerated neuron maturation.
      Neural growth in brain organoids that spent more than a month in space. Jeanne Frances Loring, National Stem Cell Foundation Researchers demonstrated that induced pluripotent stem cells (iPSCs) can be processed in microgravity using off the-shelf cell culture materials. Using standard laboratory equipment and protocols could reduce costs and make space-based biomedical research accessible to a broader range of scientists and institutions.

      Stellar Stem Cells Ax-2 evaluated how microgravity affects methods used to generate and grow stem cells into a variety of tissue types on the ground. iPSCs can give rise to any type of cell or tissue in the human body, and insight into processing in space could support their use in regenerative medicine and future large-scale biomanufacturing of cellular therapeutics in space.
      NASA astronaut Peggy Whitson, an Axiom Mission 2 crew member, works on stem cell research on a previous mission. NASA/Shane KimbroughView the full article
    • By NASA
      Bioprinted patches could help wounds heal

      Researchers successfully demonstrated the function of a handheld bioprinter that could provide a simple and effective way to treat wounds in space using human skin cells. Crews could use this technology to treat their own injuries and protect crew health and mission success in the future.

      Spaceflight can affect how wounds heal. The Bioprint FirstAid device tested a process for bioprinting a patch to cover a wound and accelerate healing. In the future, a crew member’s own cells may be used to create personalized patches for treating an injury. The bioprinting device is easy to use, can be tailored to specific needs, has a low failure rate, and its mechanics are electronics- and maintenance-free. This ESA (European Space Agency) investigation was coordinated by the German Aerospace Center (DLR).

      ESA (European Space Agency) astronaut Matthias Maurer demonstrates the Bioprint FirstAid prototype during preflight training. German Aerospace Center/European Space Agency Countering post-flight proficiency challenges

      The day they return from spaceflight, astronauts demonstrate significant impairments in fine motor control and the ability to multitask in simulated flying and driving challenges. This finding could help develop countermeasures so crew members can safely land and conduct early operations on the Moon and Mars.

      Manual Control used a battery of tests to examine how spaceflight affects cognitive, sensory, and motor function after landing. Researchers concluded that subtle physiological changes that occur during spaceflight degrade post-flight performance. Subsequent tests showed recovery of performance once exposed to the task, suggesting that simulation training immediately before a task could be an effective countermeasure. Researchers also suggest limiting dual or competing tasks during mission-critical phases.

      A simulator used to test crew members’ ability to fly and drive after spaceflight. NASA Gamma-ray telescope resilient to space radiation

      Researchers found that the station’s Glowbug gamma-ray telescope could perform in the space radiation environment for multi-year missions. Radiation can affect these types of instruments, but Glowbug regularly detected gamma ray bursts (GRBs) during its one-year operation. Studying GRBs can help scientists better understand the universe and its origins.

      Glowbug demonstrated technology to detect and characterize cosmic GRBs, primarily short GRBs, which result from mergers of compact binary star systems containing either two neutron stars or a neutron star and a black hole. Short GRBs produce gravitational waves, ripples in space that travel at the speed of light. Studying these gravitational waves could provide insight into the star systems where they originate and the behavior of matter during the mergers.

      Learn more about GRB research here.
      View the full article
    • By NASA
      Better Monitoring of the Air Astronauts Breathe

      Ten weeks of operations showed that a second version of the Spacecraft Atmosphere Monitor is sensitive enough to determine variations in the composition of cabin air inside the International Space Station. Volatile organic compounds and particulates in cabin air could pose a health risk for crew members, and this device increases the speed and accuracy of assessing such risk.

      Spacecraft Atmosphere Monitor is a miniaturized gas chromatograph mass spectrometer used to analyze the air inside the space station and ensure that it is safe for the crew and equipment. The device automatically reports results to the ground, eliminating the need to return samples to Earth. This version has several other technological advances, including that it can be relocated, is smaller, and uses less power.
      The first Spacecraft Atmosphere Monitor device on the International Space Station. NASA/Chris Cassidy Digging Deeper into Microgravity Effects on Muscle

      Prolonged exposure to microgravity affects human muscle precursor cells known as satellite cells and causes changes in the expression of specific genes involved in muscle structure and nerves. Exercise regimens on the space station do not adequately prevent or counteract muscle loss in astronauts, which can affect their motor function during missions and after return to Earth. Results could inform design of nutritional and pharmacological countermeasures to muscle changes during spaceflight.

      Muscle loss represents a major obstacle to human long-term spaceflight. Myogravity, an investigation developed with the Italian space agency ASI, looked at microgravity-induced changes in adult stem cells involved in the growth, maintenance, and repair of skeletal muscle tissue, known as satellite cells. These cells may play a major role in muscle loss during spaceflight.
      European Space Agency astronaut Paolo Nespoli sets up the Myogravity experiment. NASA Validating Next-Generation Earth Measurements

      Researchers completed a preliminary evaluation of the station’s Hyperspectral Imager Suite (HISUI) and report that the difference between model-corrected and actual measurements is small. Validation of spaceborne optical sensors like HISUI is important to demonstrate they provide the accuracy needed for scientific research.

      The JAXA (Japan Aerospace Exploration Agency) HISUI investigation tests a next-generation spaceborne hyperspectral Earth imaging system for gathering data on reflection of light from Earth’s surface, which reveals characteristics and physical properties of a target area. This technology has potential applications such as monitoring vegetation and identifying natural resources.
      The Hyperspectral Imager Suite is visible on the far left in this image outside the space station. NASAView the full article
    • By NASA
      4 min read
      Preparations for Next Moonwalk Simulations Underway (and Underwater)
      The Permafrost Tunnel north of Fairbanks, Alaska, was dug in the 1960s and is run by the U.S. Army’s Cold Regions Research and Engineering Laboratory. It is the site of much research into permafrost — ground that stays frozen throughout the year, for multiple years.NASA/Kate Ramsayer Earth’s far northern reaches have locked carbon underground for millennia. New research paints a picture of a landscape in change.
      A new study, co-authored by NASA scientists, details where and how greenhouse gases are escaping from the Earth’s vast northern permafrost region as the Arctic warms. The frozen soils encircling the Arctic from Alaska to Canada to Siberia store twice as much carbon as currently resides in the atmosphere — hundreds of billions of tons — and most of it has been buried for centuries.
      An international team, led by researchers at Stockholm University, found that from 2000 to 2020, carbon dioxide uptake by the land was largely offset by emissions from it. Overall, they concluded that the region has been a net contributor to global warming in recent decades in large part because of another greenhouse gas, methane, that is shorter-lived but traps significantly more heat per molecule than carbon dioxide.
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      Greenhouse gases shroud the globe in this animation showing data from 2021. Carbon dioxide is shown in orange; methane is shown in purple. Methane traps heat 28 times more effectively than carbon dioxide over a 100-year timescale. Wetlands are a significant source of such emissions.NASA’s Scientific Visualization Studio The findings reveal a landscape in flux, said Abhishek Chatterjee, a co-author and scientist at NASA’s Jet Propulsion Laboratory in Southern California. “We know that the permafrost region has captured and stored carbon for tens of thousands of years,” he said. “But what we are finding now is that climate-driven changes are tipping the balance toward permafrost being a net source of greenhouse gas emissions.”
      Carbon Stockpile
      Permafrost is ground that has been permanently frozen for anywhere from two years to hundreds of thousands of years. A core of it reveals thick layers of icy soils enriched with dead plant and animal matter that can be dated using radiocarbon and other techniques. When permafrost thaws and decomposes, microbes feed on this organic carbon, releasing some of it as greenhouse gases.
      Unlocking a fraction of the carbon stored in permafrost could further fuel climate change. Temperatures in the Arctic are already warming two to four times faster than the global average, and scientists are learning how thawing permafrost is shifting the region from being a net sink for greenhouse gases to becoming a net source of warming.
      They’ve tracked emissions using ground-based instruments, aircraft, and satellites. One such campaign, NASA’s Arctic-Boreal Vulnerability Experiment (ABoVE), is focused on Alaska and western Canada. Yet locating and measuring emissions across the far northern fringes of Earth remains challenging. One obstacle is the vast scale and diversity of the environment, composed of evergreen forests, sprawling tundra, and waterways.
      This map, based on data provided by the National Snow and Ice Data Center, shows the extent of Arctic permafrost. The amount of permafrost underlying the surface ranges from continuous — in the coldest areas — to more isolated and sporadic patches.NASA Earth Observatory Cracks in the Sink
      The new study was undertaken as part of the Global Carbon Project’s RECCAP-2 effort, which brings together different science teams, tools, and datasets to assess regional carbon balances every few years. The authors followed the trail of three greenhouse gases — carbon dioxide, methane, and nitrous oxide — across 7 million square miles (18 million square kilometers) of permafrost terrain from 2000 to 2020.
      Researchers found the region, especially the forests, took up a fraction more carbon dioxide than it released. This uptake was largely offset by carbon dioxide emitted from lakes and rivers, as well as from fires that burned both forest and tundra.
      They also found that the region’s lakes and wetlands were strong sources of methane during those two decades. Their waterlogged soils are low in oxygen while containing large volumes of dead vegetation and animal matter — ripe conditions for hungry microbes. Compared to carbon dioxide, methane can drive significant climate warming in short timescales before breaking down relatively quickly. Methane’s lifespan in the atmosphere is about 10 years, whereas carbon dioxide can last hundreds of years.
      The findings suggest the net change in greenhouse gases helped warm the planet over the 20-year period. But over a 100-year period, emissions and absorptions would mostly cancel each other out. In other words, the region teeters from carbon source to weak sink. The authors noted that events such as extreme wildfires and heat waves are major sources of uncertainty when projecting into the future.
      Bottom Up, Top Down
      The scientists used two main strategies to tally greenhouse gas emissions from the region. “Bottom-up” methods estimate emissions from ground- and air-based measurements and ecosystem models. Top-down methods use atmospheric measurements taken directly from satellite sensors, including those on NASA’s Orbiting Carbon Observatory-2 (OCO-2) and JAXA’s (Japan Aerospace Exploration Agency)Greenhouse Gases Observing Satellite.
      Regarding near-term, 20-year, global warming potential, both scientific approaches aligned on the big picture but differed in magnitude: The bottom-up calculations indicated significantly more warming.
      “This study is one of the first where we are able to integrate different methods and datasets to put together this very comprehensive greenhouse gas budget into one report,” Chatterjee said. “It reveals a very complex picture.”
      News Media Contacts
      Jane J. Lee / Andrew Wang
      Jet Propulsion Laboratory, Pasadena, Calif.
      818-354-0307 / 626-379-6874
      jane.j.lee@jpl.nasa.gov / andrew.wang@jpl.nasa.gov
      Written by Sally Younger
      2024-147
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      Last Updated Oct 29, 2024 Related Terms
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    • By NASA
      Microgravity had no immediate effect on a person’s ability to perceive the height of an object, indicating that astronauts can safely perform tasks that rely on accurate and precise height judgments soon after arrival in space.

      We use the height and width of objects around us to complete tasks such as reaching for objects and deciding whether we can fit through an opening. VECTION, an investigation from the Canadian Space Agency, examined the effect of microgravity on an astronaut’s visual perception and how that ability may adapt during flight or upon return to Earth. Researchers conclude there is no need for countermeasures but suggest that space travelers be made aware of late-emerging and potentially long-lasting changes in the ability to perceive object height.
      Canadian Space Agency astronaut David Saint-Jacques conducts a session for the VECTION experiment. NASA/Anne McClain Analysis of the genomes of five new species of bacteria found on the International Space Station identified specific adaptations to space, including the development of increased antibiotic resistance and a greater potential for causing diseases. The genes that facilitate these adaptations could serve as potential targets for drugs, helping to protect crew health on future missions.

      Microbial Tracking-2 monitored viruses, bacteria, and fungi on the space station to catalog and characterize any with the potential to cause disease. Understanding the mechanisms behind adaptations to space could advance development of ways to protect crew member health as well as spacecraft and equipment on future missions. Microbial adaptations also have potential applications in biotechnology, such as engineering more resilient organisms for use in space and extraterrestrial environments.
      A Microbial Tracking-2 sample collector on the International Space Station. NASA/Jack Fischer When NASA’s Airborne Lightning Observatory for Fly’s Eye and the space station’s ASIM instrument briefly passed over the same geographic area, the airborne instrument detected terrestrial gamma‐ray flashes (TGFs) that were not detected by ASIM. TGFs are short bursts of gamma‐rays produced by lightning in thunderclouds. This result suggests that a significant number of TGFs are too weak to be observed from space and that the percentage of lightning associated with these phenomena may be higher than previously thought.

      ASIM, an investigation from the European Space Agency, studies high-altitude lightning in thunderstorms and the role it plays in Earth’s atmosphere and climate. Results could help scientists develop better atmospheric models to guide weather and climate prediction and response. The airborne instrument took measurements at an altitude of about 12 miles and ASIM at approximately 260 miles above Earth’s surface.
      A view of ASIM mounted on the outside of the space station. NASAView the full article
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