Members Can Post Anonymously On This Site
Artemis Generation Shines During NASA’s 2024 Lunabotics Challenge
-
Similar Topics
-
By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
In-person participants (L-R) – Back row: Jason Lytle, Stuart Lee, Eric Bershad, Ashot Sargsyan, Aaron Everson, Philip Wells, Sergi Vaquer Araujo, Steven Grover, John A. Heit, Mehdi Shishehbor, Laura Bostick; Middle row: Sarah Childress Taoufik, Stephan Moll, Brandon Macias, Kristin Coffey, Ann-Kathrin Vlacil, Dave Francisco; Front row: James Pavela, Doug Ebert, Kathleen McMonigal, Esther Kim, Emma Hwang; Not pictured: Tyson Brunstetter, J. D. Polk
Online participants: Stephen Alamo, Mark Crowther, Steven Nissen, Mark Rosenberg, Jeffrey Weitz, R. Eugene Zierler, Serena Aunon, Tina Bayuse, Laura Beachy, Becky Brocato, Daniel Buckland, Jackie Charvat, Diana Cruz Topete, Quinn Dufurrena, Robert Haddon, Joanne Kaouk, Kim Lowe, Steve Laurie, Karina Marshall-Goebel, Sara Mason, Shannan Moynihan, James Pattarini, Devan Petersen, Ruth Reitzel, Donna Roberts, Lucia Roccaro, Mike Stenger, Terry Taddeo, Gavin Travers, Mary Van Baalen, Liz WarrenNASA In October 2024, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review the status and progress of research and clinical activities intended to mitigate the risk of venous thromboembolism (VTE) during spaceflight. The working group took place over two days at NASA’s Johnson Space Center; a second meeting on the topic was held in December 2024 at the European Space Agency (ESA) facility in Cologne, Germany.
Read More about the Risk of VTE The working group was assembled from internal NASA subject matter experts (SMEs), the NASA OCHMO Standards Team, NASA and ESA stakeholders, and external SMEs, including physicians and medical professionals from leading universities and medical centers in the United States and Canada.
Background
Spaceflight Venous Thrombosis (SVT)
Spaceflight Venous Thrombosis (SVT) refers to a phenomenon experienced during spaceflight in which a thrombus (blood clot) forms in the internal jugular vein (and/or associated vasculature) that may be symptomatic (thrombus accompanied by, but not limited to, visible internal jugular vein swelling, facial edema beyond “nominal” spaceflight adaptation, eyelid edema, and/or headache) or asymptomatic. Obstructive thrombi have been identified in a very small number of crewmembers, as shown in the figure below.
Note that the figure below is for illustrative purposes only; locations are approximate, and size is not to scale.
Approximate location of identified thrombi in crewmembers.Source: Modified from Cerebral Sinus Venous Thrombosis – University of Colorado Denver With treatment, crewmembers were able to complete their mission, and anticoagulants were discontinued several days prior to landing to minimize the risk of bleeding in the event of a traumatic injury. Some thromboses completely resolved post landing, and some required additional treatment.
Pathophysiology of Venous Thromboembolism (VTE)
The proposed pathogenesis of VTE is referred to as Virchow’s triad and suggests that VTE occurs as the result of:
Alterations in blood flow (i.e., stasis), Vascular endothelial injury/changes, and/or, Alterations in the constituents of the blood leading to hypercoagulability (i.e., hereditary predisposition or acquired hypercoagulability). Note: pathophysiology are the changes that occur during a disease process; hypercoagulability is the increased tendency to develop blood to clots.
The Virchow’s triad of risk factors for venous thrombosis.Bouchnita, 2017 Blood stasis, or venous stasis, refers to a condition in which the blood flow in the veins slows down which leads to pooling in the veins. This slowing of the blood may be due to vein valves becoming damaged or weak, immobility, and/or the absence of muscular contractions. Associated symptoms include swelling, skin changes, varicose veins, and slow-healing sores or ulcers. In terrestrial medicine, venous thrombosis is typically caused by damaged or weakened vein valves, which can be due to many factors, including aging, blood clots, varicose veins, obesity, pregnancy, sedentary lifestyle, estrogen use, and hereditary predisposition.
Spaceflight Considerations
Altered Venous Blood Flow and Spaceflight Associated Neuro-ocular Syndrome
In addition to the terrestrial risk factors of VTE, there are physiological changes associated with spaceflight that are hypothesized to potentially play a role in the development of VTE in weightlessness. Specifically, researchers have explored the effects of the microgravity environment and subsequent observed headward fluid shifts that occur, and the potential impact on blood flow. Crewmembers onboard the International Space Station (ISS) experience weightlessness due to the microgravity environment and thus experience a sustained redistribution of bodily fluids from the legs toward the head. The prolonged headward fluid shifts during weightlessness results in facial puffiness, decreased leg volume, increased cardiac stroke volume, and decreased plasma volume.
Crewmembers have also experienced altered blood flow during spaceflight, including retrograde venous blood flow (RVBF) (the backflow of venous blood towards the brain) or stasis (a stoppage or slowdown in the flow of blood). While the causes of the observed stasis and retrograde blood flow in spaceflight participants is not well understood, the potential clinical significance of the role it may have in the development of thrombus formation warrants further investigation.
Doppler imaging of a retrograde flow in the left internal jugular vein.Yan & Seow, 2009 Other physiological concerns affected by fluid shifts are being studied to consider if any relation to VTE exists. Chronic weightlessness can cause bodily fluids such as blood and cerebrospinal fluid to move toward the head, which can lead to optic nerve swelling, folds in the retina, flattening of the back of the eye, and swelling in the brain. This collection of eye and brain changes is called “spaceflight associated neuro-ocular syndrome,” or SANS. Some astronauts only experience mild changes in space, while others have clinically significant outcomes. The long-term health outcome from these changes is unknown but actively being investigated. The risk of developing SANS is higher during longer-duration missions and remains a top research priority for scientists ahead of a Mars mission.
Conclusions and Further Work
Based on expert opinion and the assessment of the risk factors for thrombosis, an algorithm was developed to provide guidance for in-mission assessment and treatment of thrombus formation in weightlessness. The algorithm is based on early in-flight ultrasound testing to determine the flow characteristic of the left internal jugular vein and associated vasculature.
NASA Working Group Recommendations
The working group recommended several areas for further investigation to assess feasibility and potential to mitigate the risk of thrombosis in spaceflight:
Improved detection capabilities to identify when a thrombus has formed in-flight, Pathophysiology/factors leading to thrombi formation during spaceflight, Countermeasures and treatment
For more information on the working group meeting and a complete list of references, please see the Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report.
Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report Share
Details
Last Updated Mar 14, 2025 EditorKim Lowe Related Terms
Office of the Chief Health and Medical Officer (OCHMO) Astronauts General Human Health and Performance Humans in Space The Human Body in Space Keep Exploring Discover Related Topics
OCHMO Independent Assessments
Independent assessment plays a crucial role in NASA’s long-term success by addressing essential questions requiring rapid response to support further…
Aerospace Medical Certification Standard
This NASA Technical Standard provides medical requirements and clinical procedures designed to ensure crew health and safety and occupational longevity…
Human Spaceflight Standards
The Human Spaceflight & Aviation Standards Team continually works with programs to provide the best standards and implementation documentation to…
Human Spaceflight and Aviation Standards
The Human Spaceflight and Aviation Standards Team continuously works with subject matter experts and with each space flight program to…
View the full article
-
By NASA
3 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
Communities in coastal areas such as Florida, shown in this 1992 NASA image, are vulnerable to the effects of sea level rise, including high-tide flooding. A new agency-led analysis found a higher-than-expected rate of sea level rise in 2024, which was also the hottest year on record.NASA Last year’s increase was due to an unusual amount of ocean warming, combined with meltwater from land-based ice such as glaciers.
Global sea level rose faster than expected in 2024, mostly because of ocean water expanding as it warms, or thermal expansion. According to a NASA-led analysis, last year’s rate of rise was 0.23 inches (0.59 centimeters) per year, compared to the expected rate of 0.17 inches (0.43 centimeters) per year.
“The rise we saw in 2024 was higher than we expected,” said Josh Willis, a sea level researcher at NASA’s Jet Propulsion Laboratory in Southern California. “Every year is a little bit different, but what’s clear is that the ocean continues to rise, and the rate of rise is getting faster and faster.”
This graph shows global mean sea level (in blue) since 1993 as measured by a series of five satellites. The solid red line indicates the trajectory of this increase, which has more than doubled over the past three decades. The dotted red line projects future sea level rise.NASA/JPL-Caltech In recent years, about two-thirds of sea level rise was from the addition of water from land into the ocean by melting ice sheets and glaciers. About a third came from thermal expansion of seawater. But in 2024, those contributions flipped, with two-thirds of sea level rise coming from thermal expansion.
“With 2024 as the warmest year on record, Earth’s expanding oceans are following suit, reaching their highest levels in three decades,” said Nadya Vinogradova Shiffer, head of physical oceanography programs and the Integrated Earth System Observatory at NASA Headquarters in Washington.
Since the satellite record of ocean height began in 1993, the rate of annual sea level rise has more than doubled. In total, global sea level has gone up by 4 inches (10 centimeters) since 1993.
This long-term record is made possible by an uninterrupted series of ocean-observing satellites starting with TOPEX/Poseidon in 1992. The current ocean-observing satellite in that series, Sentinel-6 Michael Freilich, launched in 2020 and is one of an identical pair of spacecraft that will carry this sea level dataset into its fourth decade. Its twin, the upcoming Sentinel-6B satellite, will continue to measure sea surface height down to a few centimeters for about 90% of the world’s oceans.
To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video
This animation shows the rise in global mean sea level from 1993 to 2024 based on da-ta from five international satellites. The expansion of water as it warms was responsible for the majority of the higher-than-expected rate of rise in 2024.NASA’s Scientific Visualization Studio Mixing It Up
There are several ways in which heat makes its way into the ocean, resulting in the thermal expansion of water. Normally, seawater arranges itself into layers determined by water temperature and density. Warmer water floats on top of and is lighter than cooler water, which is denser. In most places, heat from the surface moves very slowly through these layers down into the deep ocean.
But extremely windy areas of the ocean can agitate the layers enough to result in vertical mixing. Very large currents, like those found in the Southern Ocean, can tilt ocean layers, allowing surface waters to more easily slip down deep.
The massive movement of water during El Niño — in which a large pool of warm water normally located in the western Pacific Ocean sloshes over to the central and eastern Pacific — can also result in vertical movement of heat within the ocean.
Learn more about sea level:
https://sealevel.nasa.gov
News Media Contacts
Jane J. Lee / Andrew Wang
Jet Propulsion Laboratory, Pasadena, Calif.
818-354-0307 / 626-379-6874
jane.j.lee@jpl.nasa.gov / andrew.wang@jpl.nasa.gov
2025-036
Share
Details
Last Updated Mar 13, 2025 Related Terms
Sentinel-6 Michael Freilich Satellite Climate Science Jet Propulsion Laboratory Oceans Explore More
6 min read Cosmic Mapmaker: NASA’s SPHEREx Space Telescope Ready to Launch
Article 6 days ago 5 min read NASA Turns Off 2 Voyager Science Instruments to Extend Mission
Article 1 week ago 3 min read University High Knows the Answers at NASA JPL Regional Science Bowl
Article 1 week ago Keep Exploring Discover Related Topics
Missions
Humans in Space
Climate Change
Solar System
View the full article
-
By NASA
3 Min Read NASA, Partners to Conduct Space Station Research During Expedition 73
NASA NASA astronauts are gearing up for a scientific mission aboard the International Space Station. Expedition 73 NASA astronauts Nichole Ayers and Anne McClain, JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi, and Roscosmos cosmonaut Kirill Peskov will launch in March as part of the agency’s SpaceX Crew-10 mission. NASA astronaut Jonny Kim will join the crew when he launches aboard the Roscosmos Soyuz MS-27 spacecraft in April alongside Roscosmos cosmonauts Sergey Ryzhikov and Alexey Zubritsky.
Read more about some of the microgravity research planned by NASA and its partners:
Subjects for human research
NASA Astronauts often serve as test subjects, submitting blood and other samples for research. NASA astronaut Anne McClain is pictured submitting a sample on a previous mission with assistance from CSA (Canadian Space Agency) astronaut David Saint-Jacques. McClain will participate in NASA’s Complement of Integrated Protocols for Human Exploration Research investigation, or CIPHER, a suite of integrated studies on physiological and psychological changes seen in space. Results could provide valuable insights for future deep space missions.
Testing lunar navigation
NASA When Expedition 73 astronauts engage with students worldwide via the ISS Ham Radio program, researchers will use the ham radio hardware to test software for the Navigation and Communication Testbed (NAVCOM) that could help shape future lunar navigation. Researchers from the investigation recently launched a related study to the Moon aboard Firefly’s Blue Ghost to help bridge existing Earth navigation with emerging lunar-specific solutions.
Advancing fire safety
NASA Expedition 73 is scheduled to conduct a Material Ignition and Suppression Test (SoFIE-MIST), testing material flammability in microgravity. This research could improve fire safety on future missions, contributing to models used to select materials for space facilities and helping to determine the best ways to extinguish fires in space.
Keeping blood flowing
Angelo Taibi/ASI Expedition 73 crew members will participate in Drain Brain 2.0, which examines how blood flows from the brain to the heart in microgravity using this plethysmograph, a device that can record the volume of blood drainage from the skull. Results could identify which processes in the body compensate for the lack of gravity, helping to ensure proper blood flow for astronauts on future missions and people with cardiovascular issues on Earth.
The International Space Station is a convergence of science, technology, and human innovation that enables research not possible on Earth. For more than 24 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, through which astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including missions to the Moon under Artemis and, ultimately, human exploration of Mars.
Learn more about the International Space Station, its research, and its crew, at:
https://www.nasa.gov/station
Keep Exploring Discover More Topics From NASA
Space Station Research and Technology
Humans In Space
Space Station Research Results
Human Research Program
Share
Details
Last Updated Mar 10, 2025 Related Terms
ISS Research International Space Station (ISS) View the full article
-
By Space Force
U.S. military general officers and senior enlisted advisors headlined a senior leader panel during the 32nd annual National Character and Leadership Symposium at the U.S. Air Force Academy, Colorado, Feb. 21.
View the full article
-
-
Check out these Videos
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.