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By NASA
2 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The Double Asteroid Redirection Test required extreme precision in mission planning to achieve its mission of impacting an asteroid. The founders of Continuum Space worked on astrodynamics relating to this mission, which they used to inform their product.NASA Planning space missions is a very involved process, ensuring orbits are lined up and spacecraft have enough fuel is imperative to the long-term survival of orbital assets. Continuum Space Systems Inc. of Pasadena, California, produces a cloud-based platform that gives mission planners everything they need to certify that their space resources can accomplish their goals.
Continuum’s story begins at NASA’s Jet Propulsion Laboratory in Southern California. Loic Chappaz, the company’s co-founder, started at JPL as an intern working on astrodynamics related to NASA’s Double Asteroid Redirection Test. There he met Leon Alkalai, a JPL technical fellow who spent his 30-year career at the center planning deep space missions. After Alkalai retired from NASA, he founded Mandala Space Ventures, a startup that explored several avenues of commercial space development. Chappaz soon became Mandala’s first employee, but to plan their future, Mandala’s leadership began thinking about the act of planning itself.
Because the staff had decades of combined experience at JPL, they knew the center had the building blocks for the software they needed. After licensing several pieces of software from JPL, the company began building planning systems that were highly adaptable to any space mission they could come up with. Mandala eventually evolved into a venture firm that incubated space-related startups. However, because Mandala had invested considerably in developing mission-planning tools, further development could be performed by a new company, and Continuum was fully spun off from Mandala in 2021.
Continuum’s platform includes several features for mission planners, such as plotting orbital maneuvers and risk management evaluations. Some of these are built upon software licensed from the Jet Propulsion Laboratory.Continuum Space Systems Inc. Continuum’s tools are designed to take a space mission from concept to completion. There are three different components to their “mission in a box” — design, build and test, and mission operations. The base of these tools are several pieces of software developed at NASA. As of 2024, several space startups have begun planning missions with Continuum’s NASA-inspired software, as well as established operators of satellite constellations. From Continuum to several startups, NASA technologies continue to prove a valuable foundation for the nation’s space economy.
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Last Updated Mar 25, 2025 Related Terms
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By Space Force
Since the Space Force stood up five years ago, it has delivered warfighting effects to the point that the U.S. can now contest the space domain, Space Force Chief of Space Operations Gen. B. Chance Saltzman said.
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
In-person participants (L-R) – Back row: Jason Lytle, Stuart Lee, Eric Bershad, Ashot Sargsyan, Aaron Everson, Philip Wells, Sergi Vaquer Araujo, Steven Grover, John A. Heit, Mehdi Shishehbor, Laura Bostick; Middle row: Sarah Childress Taoufik, Stephan Moll, Brandon Macias, Kristin Coffey, Ann-Kathrin Vlacil, Dave Francisco; Front row: James Pavela, Doug Ebert, Kathleen McMonigal, Esther Kim, Emma Hwang; Not pictured: Tyson Brunstetter, J. D. Polk
Online participants: Stephen Alamo, Mark Crowther, Steven Nissen, Mark Rosenberg, Jeffrey Weitz, R. Eugene Zierler, Serena Aunon, Tina Bayuse, Laura Beachy, Becky Brocato, Daniel Buckland, Jackie Charvat, Diana Cruz Topete, Quinn Dufurrena, Robert Haddon, Joanne Kaouk, Kim Lowe, Steve Laurie, Karina Marshall-Goebel, Sara Mason, Shannan Moynihan, James Pattarini, Devan Petersen, Ruth Reitzel, Donna Roberts, Lucia Roccaro, Mike Stenger, Terry Taddeo, Gavin Travers, Mary Van Baalen, Liz WarrenNASA In October 2024, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review the status and progress of research and clinical activities intended to mitigate the risk of venous thromboembolism (VTE) during spaceflight. The working group took place over two days at NASA’s Johnson Space Center; a second meeting on the topic was held in December 2024 at the European Space Agency (ESA) facility in Cologne, Germany.
Read More about the Risk of VTE The working group was assembled from internal NASA subject matter experts (SMEs), the NASA OCHMO Standards Team, NASA and ESA stakeholders, and external SMEs, including physicians and medical professionals from leading universities and medical centers in the United States and Canada.
Background
Spaceflight Venous Thrombosis (SVT)
Spaceflight Venous Thrombosis (SVT) refers to a phenomenon experienced during spaceflight in which a thrombus (blood clot) forms in the internal jugular vein (and/or associated vasculature) that may be symptomatic (thrombus accompanied by, but not limited to, visible internal jugular vein swelling, facial edema beyond “nominal” spaceflight adaptation, eyelid edema, and/or headache) or asymptomatic. Obstructive thrombi have been identified in a very small number of crewmembers, as shown in the figure below.
Note that the figure below is for illustrative purposes only; locations are approximate, and size is not to scale.
Approximate location of identified thrombi in crewmembers.Source: Modified from Cerebral Sinus Venous Thrombosis – University of Colorado Denver With treatment, crewmembers were able to complete their mission, and anticoagulants were discontinued several days prior to landing to minimize the risk of bleeding in the event of a traumatic injury. Some thromboses completely resolved post landing, and some required additional treatment.
Pathophysiology of Venous Thromboembolism (VTE)
The proposed pathogenesis of VTE is referred to as Virchow’s triad and suggests that VTE occurs as the result of:
Alterations in blood flow (i.e., stasis), Vascular endothelial injury/changes, and/or, Alterations in the constituents of the blood leading to hypercoagulability (i.e., hereditary predisposition or acquired hypercoagulability). Note: pathophysiology are the changes that occur during a disease process; hypercoagulability is the increased tendency to develop blood to clots.
The Virchow’s triad of risk factors for venous thrombosis.Bouchnita, 2017 Blood stasis, or venous stasis, refers to a condition in which the blood flow in the veins slows down which leads to pooling in the veins. This slowing of the blood may be due to vein valves becoming damaged or weak, immobility, and/or the absence of muscular contractions. Associated symptoms include swelling, skin changes, varicose veins, and slow-healing sores or ulcers. In terrestrial medicine, venous thrombosis is typically caused by damaged or weakened vein valves, which can be due to many factors, including aging, blood clots, varicose veins, obesity, pregnancy, sedentary lifestyle, estrogen use, and hereditary predisposition.
Spaceflight Considerations
Altered Venous Blood Flow and Spaceflight Associated Neuro-ocular Syndrome
In addition to the terrestrial risk factors of VTE, there are physiological changes associated with spaceflight that are hypothesized to potentially play a role in the development of VTE in weightlessness. Specifically, researchers have explored the effects of the microgravity environment and subsequent observed headward fluid shifts that occur, and the potential impact on blood flow. Crewmembers onboard the International Space Station (ISS) experience weightlessness due to the microgravity environment and thus experience a sustained redistribution of bodily fluids from the legs toward the head. The prolonged headward fluid shifts during weightlessness results in facial puffiness, decreased leg volume, increased cardiac stroke volume, and decreased plasma volume.
Crewmembers have also experienced altered blood flow during spaceflight, including retrograde venous blood flow (RVBF) (the backflow of venous blood towards the brain) or stasis (a stoppage or slowdown in the flow of blood). While the causes of the observed stasis and retrograde blood flow in spaceflight participants is not well understood, the potential clinical significance of the role it may have in the development of thrombus formation warrants further investigation.
Doppler imaging of a retrograde flow in the left internal jugular vein.Yan & Seow, 2009 Other physiological concerns affected by fluid shifts are being studied to consider if any relation to VTE exists. Chronic weightlessness can cause bodily fluids such as blood and cerebrospinal fluid to move toward the head, which can lead to optic nerve swelling, folds in the retina, flattening of the back of the eye, and swelling in the brain. This collection of eye and brain changes is called “spaceflight associated neuro-ocular syndrome,” or SANS. Some astronauts only experience mild changes in space, while others have clinically significant outcomes. The long-term health outcome from these changes is unknown but actively being investigated. The risk of developing SANS is higher during longer-duration missions and remains a top research priority for scientists ahead of a Mars mission.
Conclusions and Further Work
Based on expert opinion and the assessment of the risk factors for thrombosis, an algorithm was developed to provide guidance for in-mission assessment and treatment of thrombus formation in weightlessness. The algorithm is based on early in-flight ultrasound testing to determine the flow characteristic of the left internal jugular vein and associated vasculature.
NASA Working Group Recommendations
The working group recommended several areas for further investigation to assess feasibility and potential to mitigate the risk of thrombosis in spaceflight:
Improved detection capabilities to identify when a thrombus has formed in-flight, Pathophysiology/factors leading to thrombi formation during spaceflight, Countermeasures and treatment
For more information on the working group meeting and a complete list of references, please see the Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report.
Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report Share
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Last Updated Mar 14, 2025 EditorKim Lowe Related Terms
Office of the Chief Health and Medical Officer (OCHMO) Astronauts General Human Health and Performance Humans in Space The Human Body in Space Keep Exploring Discover Related Topics
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By NASA
Center Director Dr. Jimmy Kenyon gives an overview of NASA Glenn Research Center’s areas of expertise and how it supports the agency’s missions and programs. Credit: NASA/Susan Valerian NASA Glenn Research Center’s Director Dr. Jimmy Kenyon and Chief Counsel Callista Puchmeyer participated in a local symposium that addressed the operational and legal challenges of human spaceflight. The one-day conference was held at the Cleveland State University (CSU) College of Law on Feb.13.
Kenyon gave a keynote that provided an overview of NASA Glenn’s areas of expertise and how the center supports the agency’s missions and programs. He also talked about the role of growing commercial partnerships at NASA.
Panelists, left to right: Col. (Ret.) Joseph Zeis, senior advisor for Aerospace and Defense, Office of the Governor of Ohio; Callista Puchmeyer, chief counsel, NASA’s Glenn Research Center; and Jon. P. Yormick, international business and trade attorney, Yormick Law, answer questions on operational and legal challenges of human spaceflight at a Cleveland State University College of Law symposium. Credit: NASA/Susan Valerian Puchmeyer, a graduate of CSU’s College of Law and recent inductee into its Hall of Fame, participated in a panel about Northeast Ohio’s aerospace industry and the legal aspects of commercial partnerships.
Additionally, human spaceflight experts from academia, law, and science spoke throughout the day on topics ranging from the health and training of astronauts to the special law of space stations. Romanian astronaut Dumitru-Dorin Prunariu joined remotely to provide a personal perspective.
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By NASA
1 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
Astronaut Serena M. Auñón-Chancellor Examines Her Eyes in SpaceNASA Exposure to altered gravity can cause ocular and brain structural changes to develop during spaceflight; these changes could lead to vision alterations, cognitive effects, or other deleterious health effects. SANS is a syndrome unique to humans that fly in space, and there is no terrestrial disease equivalent. Brain structural changes appear small but seem to indicate that over half of crewmembers experience one or more symptoms of SANS. Determining intracranial pressure during spaceflight could improve our understanding of SANS mechanisms and improve our ability to target countermeasures for determining risk for future missions.
NASA astronaut Karen Nyberg, Expedition 36 flight engineer, conducts an ocular health exam on herself in the Destiny laboratory of the Earth-orbiting International Space Station. (NASA)NASA Directed Acyclic Graph Files
+ DAG File Information (HSRB Home Page)
+ SANS Risk DAG and Narrative (PDF)
+ SANS Risk DAG Code (TXT)
Human Research Roadmap
+ Risk of Spaceflight Associated Neuro-ocular Syndrome
+ 2022 April Evidence Report (PDF)
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Last Updated Mar 11, 2025 EditorRobert E. LewisLocationJohnson Space Center Related Terms
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