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Spaceflight effects tumor-bearing fruit fly hosts and their parasites


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How does spaceflight affect tumor-bearing fruit fly hosts and their parasites?

Different specimens of male parasitic wasps that were flown in space
Pigmentation: A side-by-side comparison of wasps shows a clear difference in the melanization of wing veins for wild-type and each mutant.
Blade Shape: The kona mutant has an angular wing shape in contrast to wild-type’s rounded wing blade (vertical arrows in D–F).
S. Govind.

Background: Like humans, fruit flies (a model organism for spaceflight research) also exhibit immune system dysfunction in space. Despite decades of studies on fruit flies and wasps, little was known about how their immune systems interact with natural parasites in space. Drosophila parasitoid wasps modify blood cell function to suppress host immunity. In this spaceflight study (the Fruit Fly-03 Lab flown to the ISS on SpaceX-14), naive and parasitized ground and space flies from a tumor-free control and a blood tumor-bearing mutant strain were examined.

Main Findings: Surprisingly, the flies without tumors were more sensitive to space than the flies with tumors. Spaceflight increased immune gene activity and made tumors grow more in the flies. The wasps remained harmful in space, but some developed inheritable physical changes. These changes included “aurum” (altered wing color and veins) and “kona” (altered wing shape). Female wasps with two copies of the “kona” mutation could not lay eggs because of defective egg-laying organs.

parasitic-wasp-ovipositors.jpg?w=1693
Ovipositors from wild-type and mutant wasps.
Homozygous kona females with defective ovipositors (used for egg laying) how areas of compromised integrity or have branched ends (arrows) compared to the continuous ovipositors with sharp ends from wild-type control wasps.
S. Govind

Impact: This study will Improve our knowledge of how parasites and hosts interact. The results show that we need to study more types of organisms, including plants and their natural parasites, in space. This will help us learn more about how hosts defend themselves and how dangerous parasites can be in space, which is important for astronaut health. Gene expression data from fruit flies (OSD-588) and two types of wasps (OSD-609 & OSD-610) are publicly available on NASA’s Open Science Data Repository. This data is available for anyone to use and compare with other spaceflight studies.

Reference: Chou, J., Ramroop, J.,  Saravia-Butler, A., Wey, B., Lera, M., Torres, M., Heavner, M., Iyer, J., Mhatre, S,. Bhattacharya, S., Govind, S. Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids. iScience, Volume 27, Issue 1, 2024, 108759, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.108759

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      To achieve these two objectives, planners organized an applied user panel and a breakout session as means to foster conversation among participants. The applied user panel consisted of five panelists– three participating virtually and two in-person. The presenters in the session shared their responses to three prepared discussion prompts: 1) an introduction of ICESat-2 data products; 2) use of ICESat-2 data products for their application; and 3) potential data latency impacts. The conversation was brief, but it provided a unique opportunity to hear from experienced applied users.
      A breakout session consisted of pre-planned discussion prompts through two virtual breakout groups and one in-person group. Group One discussed questions that covered examination of ice crevassing and rifting, community tools for shallow water mapping, and slope measurement bias and uncertainties. Group Two discussed a variety of current and potential surface water applications, identified challenges using ICEat-2 data, and developed suggestions to increase the accessibility and usability of ICESat-2 data products. Group Three covered a gamut of topics, including potential products for Alaskan and Canadian communities, increased accessibility to products, and applications through central cloud storage systems, central repositories and detailed documentation, and the desire for future topic-specific workshops and focus sessions.
      Conclusion
      The 2024 NASA ICESat-2 Applications Workshop was the third in a series of workshops – with the first workshop occurring in 2012, six years prior to launch. The EA program was transitioned to the Applied User program, which deployed a post-launch program per the NASA Early Adopter Handbook “that acts as a continuation of the Early Adopter program to engage with Communities of Practice and Potential.” This workshop provided the space to foster collaboration and conceptualization of applications not yet exploited that may be developed using ICESat-2 data products. The workshop met its objectives and created an environment that fostered collaboration between participants. The workshop was a success, and participants requested another one focused on a thematic topic. Updates, future workshops, and other events will be posted on the ICESat-2 ‘Get Involved’ page.
      Aimee Renee Neeley
      NASA’s Goddard Space Flight Center/Science Systems and Applications, Inc.
      aimee.neeley@nasa.gov
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      To learn more, visit: https://www.nasa.gov/space-technology-mission-directorate/
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      Last Updated Aug 28, 2024 EditorLoura Hall Related Terms
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    • By NASA
      5 Min Read Webb Finds Early Galaxies Weren’t Too Big for Their Britches After All
      This image shows a small portion of the field observed by NASA’s James Webb Space Telescope’s NIRCam (Near-Infrared Camera) for the Cosmic Evolution Early Release Science (CEERS) survey. The full image appears below. Credits:
      NASA, ESA, CSA, S. Finkelstein (University of Texas) It got called the crisis in cosmology. But now astronomers can explain some surprising recent discoveries.
      When astronomers got their first glimpses of galaxies in the early universe from NASA’s James Webb Space Telescope, they were expecting to find galactic pipsqueaks, but instead they found what appeared to be a bevy of Olympic bodybuilders. Some galaxies appeared to have grown so massive, so quickly, that simulations couldn’t account for them. Some researchers suggested this meant that something might be wrong with the theory that explains what the universe is made of and how it has evolved since the big bang, known as the standard model of cosmology.
      According to a new study in the Astrophysical Journal led by University of Texas at Austin graduate student Katherine Chworowsky, some of those early galaxies are in fact much less massive than they first appeared. Black holes in some of these galaxies make them appear much brighter and bigger than they really are.
      “We are still seeing more galaxies than predicted, although none of them are so massive that they ‘break’ the universe,” Chworowsky said.
      The evidence was provided by Webb’s Cosmic Evolution Early Release Science (CEERS) Survey, led by Steven Finkelstein, a professor of astronomy at UT Austin and study co-author.
      Image A : CEERS Deep Field (NIRCam)
      This image shows a small portion of the field observed by NASA’s James Webb Space Telescope’s NIRCam (Near-Infrared Camera) for the Cosmic Evolution Early Release Science (CEERS) survey. It is filled with galaxies. Some galaxies appear to have grown so massive, so quickly, that simulations couldn’t account for them. However, a new study finds that some of those early galaxies are in fact much less massive than they first appeared. Black holes in some of those galaxies make them appear much brighter and bigger than they really are. NASA, ESA, CSA, S. Finkelstein (University of Texas)
      View 8k pixel full resolution version of the image

      Black Holes Add to Brightness
      According to this latest study, the galaxies that appeared overly massive likely host black holes rapidly consuming gas. Friction in the fast-moving gas emits heat and light, making these galaxies much brighter than they would be if that light emanated just from stars. This extra light can make it appear that the galaxies contain many more stars, and hence are more massive, than we would otherwise estimate. When scientists remove these galaxies, dubbed “little red dots” (based on their red color and small size), from the analysis, the remaining early galaxies are not too massive to fit within predictions of the standard model.
      “So, the bottom line is there is no crisis in terms of the standard model of cosmology,” Finkelstein said. “Any time you have a theory that has stood the test of time for so long, you have to have overwhelming evidence to really throw it out. And that’s simply not the case.”
      Efficient Star Factories
      Although they’ve settled the main dilemma, a less thorny problem remains: There are still roughly twice as many massive galaxies in Webb’s data of the early universe than expected from the standard model. One possible reason might be that stars formed more quickly in the early universe than they do today.
      “Maybe in the early universe, galaxies were better at turning gas into stars,” Chworowsky said.
      Star formation happens when hot gas cools enough to succumb to gravity and condense into one or more stars. But as the gas contracts, it heats up, generating outward pressure. In our region of the universe, the balance of these opposing forces tends to make the star formation process very slow. But perhaps, according to some theories, because the early universe was denser than today, it was harder to blow gas out during star formation, allowing the process to go faster.
      More Evidence of Black Holes
      Concurrently, astronomers have been analyzing the spectra of “little red dots” discovered with Webb, with researchers in both the CEERS team and others finding evidence of fast-moving hydrogen gas, a signature of black hole accretion disks. This supports the idea that at least some of the light coming from these compact, red objects comes from gas swirling around black holes, rather than stars – reinforcing Chworowsky and their team’s conclusion that they are probably not as massive as astronomers initially thought.  However, further observations of these intriguing objects are incoming, and should help solve the puzzle about how much light comes from stars versus gas around black holes.
      Often in science, when you answer one question, that leads to new questions. While Chworowsky and their colleagues have shown that the standard model of cosmology likely isn’t broken, their work points to the need for new ideas in star formation.
      “And so there is still that sense of intrigue,” Chworowsky said. “Not everything is fully understood. That’s what makes doing this kind of science fun, because it’d be a terribly boring field if one paper figured everything out, or there were no more questions to answer.”The James Webb Space Telescope is the world’s premier space science observatory. Webb is solving mysteries in our solar system, looking beyond to distant worlds around other stars, and probing the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).
      Downloads
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      View/Download all image products at all resolutions for this article from the Space Telescope Science Institute.
      View/Download the research results from the Astrophysical Journal .
      Media Contacts
      Laura Betz – laura.e.betz@nasa.gov, Rob Gutro – rob.gutro@nasa.gov
      NASA’s Goddard Space Flight Center, Greenbelt, Md.
      Marc Airhart – mairhart@austin.utexas.edu
      University of Texas at Austin
      Christine Pulliam – cpulliam@stsci.edu
      Space Telescope Science Institute, Baltimore, Md.
      Related Information
      VIDEO: CEERS Fly-through data visualization
      ARTICLE: Webb Science – Galaxies Through Time
      INFOGRAPHIC: Learn More about black holes
      VIDEO: Webb Science Snippets Video: “The Early Universe”
      INFOGRAPHIC: What is Cosmological Redshift?
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      Last Updated Aug 26, 2024 Editor Stephen Sabia Contact Laura Betz laura.e.betz@nasa.gov Related Terms
      Astrophysics Galaxies Galaxies, Stars, & Black Holes Galaxies, Stars, & Black Holes Research Goddard Space Flight Center James Webb Space Telescope (JWST) Science & Research The Universe View the full article
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