Jump to content

Spaceflight effects tumor-bearing fruit fly hosts and their parasites


Recommended Posts

  • Publishers
Posted

How does spaceflight affect tumor-bearing fruit fly hosts and their parasites?

Different specimens of male parasitic wasps that were flown in space
Pigmentation: A side-by-side comparison of wasps shows a clear difference in the melanization of wing veins for wild-type and each mutant.
Blade Shape: The kona mutant has an angular wing shape in contrast to wild-type’s rounded wing blade (vertical arrows in D–F).
S. Govind.

Background: Like humans, fruit flies (a model organism for spaceflight research) also exhibit immune system dysfunction in space. Despite decades of studies on fruit flies and wasps, little was known about how their immune systems interact with natural parasites in space. Drosophila parasitoid wasps modify blood cell function to suppress host immunity. In this spaceflight study (the Fruit Fly-03 Lab flown to the ISS on SpaceX-14), naive and parasitized ground and space flies from a tumor-free control and a blood tumor-bearing mutant strain were examined.

Main Findings: Surprisingly, the flies without tumors were more sensitive to space than the flies with tumors. Spaceflight increased immune gene activity and made tumors grow more in the flies. The wasps remained harmful in space, but some developed inheritable physical changes. These changes included “aurum” (altered wing color and veins) and “kona” (altered wing shape). Female wasps with two copies of the “kona” mutation could not lay eggs because of defective egg-laying organs.

parasitic-wasp-ovipositors.jpg?w=1693
Ovipositors from wild-type and mutant wasps.
Homozygous kona females with defective ovipositors (used for egg laying) how areas of compromised integrity or have branched ends (arrows) compared to the continuous ovipositors with sharp ends from wild-type control wasps.
S. Govind

Impact: This study will Improve our knowledge of how parasites and hosts interact. The results show that we need to study more types of organisms, including plants and their natural parasites, in space. This will help us learn more about how hosts defend themselves and how dangerous parasites can be in space, which is important for astronaut health. Gene expression data from fruit flies (OSD-588) and two types of wasps (OSD-609 & OSD-610) are publicly available on NASA’s Open Science Data Repository. This data is available for anyone to use and compare with other spaceflight studies.

Reference: Chou, J., Ramroop, J.,  Saravia-Butler, A., Wey, B., Lera, M., Torres, M., Heavner, M., Iyer, J., Mhatre, S,. Bhattacharya, S., Govind, S. Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids. iScience, Volume 27, Issue 1, 2024, 108759, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.108759

View the full article

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Similar Topics

    • By NASA
      A rendering of Firefly’s Blue Ghost lunar lander and a rover developed for the company’s third mission to the Moon as part of NASA’s CLPS (Commercial Lunar Payload Services) initiative.Credit: Firefly Aerospace NASA continues to advance its campaign to explore more of the Moon than ever before, awarding Firefly Aerospace $179 million to deliver six experiments to the lunar surface. This fourth task order for Firefly will target landing in the Gruithuisen Domes on the near side of the Moon in 2028.
      As part of the agency’s broader Artemis campaign, Firefly will deliver a group of science experiments and technology demonstrations under NASA’s CLPS initiative, or Commercial Lunar Payload Services, to these lunar domes, an area of ancient lava flows, to better understand planetary processes and evolution. Through CLPS, NASA is furthering our understanding of the Moon’s environment and helping prepare for future human missions to the lunar surface, as part of the agency’s Moon to Mars exploration approach. 
      “The CLPS initiative carries out U.S. scientific and technical studies on the surface of the Moon by robot explorers. As NASA prepares for future human exploration of the Moon, the CLPS initiative continues to support a growing lunar economy with American companies,” said Joel Kearns, deputy associate administrator for exploration, Science Mission Directorate, NASA Headquarters in Washington. “Understanding the formation of the Gruithuisen Domes, as well as the ancient lava flows surrounding the landing site, will help the U.S. answer important questions about the lunar surface.”
      Firefly’s first lunar delivery is scheduled to launch no earlier than mid-January 2025 and will land near a volcanic feature called Mons Latreille within Mare Crisium, on the northeast quadrant of the Moon’s near side. Firefly’s second lunar mission includes two task orders: a lunar orbit drop-off of a satellite combined with a delivery to the lunar surface on the far side and a delivery of a lunar orbital calibration source, scheduled in 2026.
      This new delivery in 2028 will send payloads to the Gruithuisen Domes and the nearby Sinus Viscositatus. The Gruithuisen Domes have long been suspected to be formed by a magma rich in silica, similar in composition to granite. Granitic rocks form easily on Earth due to plate tectonics and oceans of water. The Moon lacks these key ingredients, so lunar scientists have been left to wonder how these domes formed and evolved over time. For the first time, as part of this task order, NASA also has contracted to provide “mobility,” or roving, for some of the scientific instruments on the lunar surface after landing. This will enable new types of U.S. scientific investigations from CLPS.
      “Firefly will deliver six instruments to understand the landing site and surrounding vicinity,” said Chris Culbert, manager of the CLPS initiative at NASA’s Johnson Space Center in Houston. “These instruments will study geologic processes and lunar regolith, test solar cells, and characterize the neutron radiation environment, supplying invaluable information as NASA works to establish a long-term presence on the Moon.”
      The instruments, collectively expected to be about 215 pounds (97 kilograms) in mass, include: 
      Lunar Vulkan Imaging and Spectroscopy Explorer, which consists of two stationary and three mobile instruments, will study rocks and regoliths on the summit of one of the domes to determine their origin and better understand geologic processes of early planetary bodies. The principal investigator is Dr. Kerri Donaldson Hanna of the University of Central Florida, Orlando. Heimdall is a flexible camera system that will be used to take pictures of the landing site from above the horizon to the ground directly below the lander. The principal investigator is Dr. R. Aileen Yingst of the Planetary Science Institute, Tucson, Arizona. Sample Acquisition, Morphology Filtering, and Probing of Lunar Regolith is a robotic arm that will collect samples of lunar regolith and use a robotic scoop to filter and isolate particles of different sizes. The sampling technology will use a flight spare from the Mars Exploration Rover project. The principal investigator is Sean Dougherty of Maxar Technologies, Westminster, Colorado. Low-frequency Radio Observations from the Near Side Lunar Surface is designed to observe the Moon’s surface environment in radio frequencies, to determine whether natural and human-generated activity near the surface interferes with science. The project is headed up by Natchimuthuk Gopalswamy of NASA’s Goddard Space Flight Center in Greenbelt, Maryland.  Photovoltaic Investigation on the Lunar Surface will carry a set of the latest solar cells for a technology demonstration of light-to-electricity power conversion for future missions. The experiment will also collect data on the electrical charging environment of the lunar surface using a small array of solar cells. The principal investigator is Jeremiah McNatt from NASA’s Glenn Research Center in Cleveland. Neutron Measurements at the Lunar Surface is a neutron spectrometer that will characterize the surface neutron radiation environment, monitor hydrogen, and provide constraints on elemental composition. The principal investigator is Dr. Heidi Haviland of NASA’s Marshall Spaceflight Center in Huntsville, Alabama. Through the CLPS initiative, NASA purchases lunar landing and surface operations services from American companies. The agency uses CLPS to send scientific instruments and technology demonstrations to advance capabilities for science, exploration, or commercial development of the Moon. By supporting a robust cadence of lunar deliveries, NASA will continue to enable a growing lunar economy while leveraging the entrepreneurial innovation of the commercial space industry. Two upcoming CLPS flights scheduled to launch in early 2025 will deliver NASA payloads to the Moon’s near side and south polar region, respectively.
      Learn more about CLPS and Artemis at:
      https://www.nasa.gov/clps
      -end-
      Alise Fisher
      Headquarters, Washington
      202-358-2546
      alise.m.fisher@nasa.gov
      Natalia Riusech / Nilufar Ramji    
      Johnson Space Center, Houston
      281-483-5111
      natalia.s.riusech@nasa.gov / nilufar.ramji@nasa.gov
      Share
      Details
      Last Updated Dec 18, 2024 LocationNASA Headquarters Related Terms
      Commercial Lunar Payload Services (CLPS) Artemis View the full article
    • By European Space Agency
      On 4 December 2024, the European Space Agency (ESA) and the Indian Space Research Organisation (ISRO) signed an agreement that will see ESA provide ground station support to the missions in ISRO’s Gaganyaan human spaceflight programme.
      View the full article
    • By NASA
      At the edge of Las Cruces, New Mexico, surrounded by miles of sunbaked earth, NASA’s White Sands Test Facility (WSTF) is quietly shaping the future. There is no flash, no fanfare — the self-contained facility operates as it has since 1962, humbly and in relative obscurity.

      Yet as New Mexico’s space industry skyrockets amid intensifying commercial spaceflight efforts across the state, WSTF feels a new urgency to connect with the community. With the facility’s latest Test and Evaluation Support Team (TEST3) contract now in its third year, Program Manager Michelle Meerscheidt is determined to make a mark.

      “I think it’s very important we increase our public presence,” Meerscheidt said. “We are a significant contributor to NASA’s mission and our country’s aspirations for furthering space exploration.”

      In September, TEST3 leadership joined forces with the City of Las Cruces to support the sixth annual Las Cruces Space Festival, a two-weekend celebration of the region’s rich relationship with the aerospace industry.

      The Test and Evaluation Support Team (TEST3) team — Human Resources Manager Kristina Garcia (left), Program Manager Michelle Meerscheidt, and Deputy Program Manager/Business Manager Karen Lucht — prepares to meet with visitors at the Las Cruces Space Festival Astronomy & Industry Night on Sept. 13, 2024, in Las Cruces, New Mexico. NASA/Anthony Luis Quiterio Alongside WSTF, festival director Alice Carruth is working to open a world that many believe is off limits and others don’t know exists.

      “Unless you’re driving over the mountains regularly and seeing the sign that says, ‘The Birthplace of the U.S. Space and Missile Program,’ you don’t tend to know what’s going on in your backyard,”  Carruth said.

      “The whole premise of the Space Festival is to make people understand what’s going on in their community, to encourage people to think about careers in the space industry, and to inspire the next generation.”

      A featured speaker at the festival’s New Mexico State University Astronomy & Industry Night, Meerscheidt had the chance to do just that.

      “It’s fun to see a lot of young kids that are wide-eyed and excited,” Meerscheidt said. “It’s nice to be able to encourage them to pursue their dreams.”

      Among those wide-eyed festivalgoers was 6-year-old Camilla Medina-Bond, who was confident in her vision for the future.

      “I want to be an astronaut when I grow up,” she said. “I want to visit the Moon.”

      As for the details of her lunar mission, Medina-Bond’s plan is simple: “Just going to see what’s on it.” She has plenty of time to figure out the specifics — after all, giant leaps start with small steps. According to Meerscheidt, the aspiring astronaut has already taken the first and most critical step.

      “That’s what NASA is all about,” Meerscheidt said. “Explore, be inquisitive. Open your mind, open your imagination, and go for it.”

      Left: Camilla Medina-Bond, age 6, proudly shows off her foam stomp rocket and NASA White Sands Test Facility baseball cap during the Las Cruces Space Festival’s Astronomy & Industry Night on the New Mexico State University campus. Right: Medina-Bond immerses herself in another world as she operates a virtual reality headset. NASA/Anthony Luis Quiterio Medina-Bond’s aspiration is shared by many young dreamers. A 2024 global study by longtime NASA partner, the LEGO Group, found 77% of kids ages 4-14 want to travel to space.

      Carruth acknowledged that keeping the attention of today’s always-scrolling, trend-driven generation is not easy, and that children’s fascination with space often wanes as they age.

      “If you look at the statistics, space tends to be really cool until they get to middle school level, and then space isn’t cool anymore — not because it’s not cool, but because it then becomes inaccessible to a lot of students,” she said.

      Still, Carruth is prepared to navigate the challenge.

      “I want kids to understand that space is for everybody,” Carruth said. “I also want their parents and grandparents to understand why space is important and that this is a feasible career.”

      Oscar Castrejon, who attended the festival with his 12-year-old son, Oscar Jr., is on his own mission to nurture that understanding. “I’ve learned early kids need to develop their own passions, but if they say ‘hey, I like this, I’m interested in it,’ then I’ll take them to it,” Castrejon said. “If their eyes get opened, if their imagination gets sparked, you never know — you could be looking at the next NASA scientist.”

      Oscar Castrejon and his son Oscar Jr., age 12, stop by the White Sands TEST3 booth. Anthony Luis Quiterio WSTF TEST3 Deputy Program Manager and Business Manager Karen Lucht shares Castrejon’s philosophy, emphasizing the importance of authenticity.

      “Speak[ing] to who you are as a person will ultimately lead to who you will become as a professional,” she said.

      A remote test site, WSTF has its own ecosystem which Lucht compares to a “small city.” Among its residents are scientists and engineers, but also welders, writers, firefighters, and photographers — to name a few.

      “White Sands offers endless opportunities for everybody,” Lucht said. “Every career has a path here.”

      Lucht’s own journey illustrates the infinite potential that arises in diverse spaces like WSTF.

      “I came from a town of less than a thousand people, and I never dreamt that I would work for NASA,” she said. “As someone who was told many times that I would never make it to my position, I look back on my career and realize there are no restraints. You really can do anything you want to do.”

      For those wanting to join the ranks at WSTF, there is one important requirement: they must see themselves as stardust, a vital element in a grand cosmic plan.

      “We’re looking for people who have the right perspective, the desire to learn and contribute to something bigger than themselves,” Lucht said.

      At WSTF — a place where the stars feel close enough to touch — the sky is not the limit, it is only the beginning.
      View the full article
    • By Space Force
      SecAF Kendall delivered a speech to USAFA cadets about the qualities necessary for strong leadership and why capable, insightful, moral leaders are more essential than ever in defense of the nation.

      View the full article
    • By NASA
      5 min read
      Preparations for Next Moonwalk Simulations Underway (and Underwater)
      A prototype of a robot designed to explore subsurface oceans of icy moons is reflected in the water’s surface during a pool test at Caltech in September. Conducted by NASA’s Jet Propulsion Laboratory, the testing showed the feasibility of a mission concept for a swarm of mini swimming robots.NASA/JPL-Caltech In a competition swimming pool, engineers tested prototypes for a futuristic mission concept: a swarm of underwater robots that could look for signs of life on ocean worlds.
      When NASA’s Europa Clipper reaches its destination in 2030, the spacecraft will prepare to aim an array of powerful science instruments toward Jupiter’s moon Europa during 49 flybys, looking for signs that the ocean beneath the moon’s icy crust could sustain life. While the spacecraft, which launched Oct. 14, carries the most advanced science hardware NASA has ever sent to the outer solar system, teams are already developing the next generation of robotic concepts that could potentially plunge into the watery depths of Europa and other ocean worlds, taking the science even further.
      This is where an ocean-exploration mission concept called SWIM comes in. Short for Sensing With Independent Micro-swimmers, the project envisions a swarm of dozens of self-propelled, cellphone-size swimming robots that, once delivered to a subsurface ocean by an ice-melting cryobot, would zoom off, looking for chemical and temperature signals that could indicate life.
      Dive into underwater robotics testing with NASA’s futuristic SWIM (Sensing With Independent Micro-swimmers) concept for a swarm of miniature robots to explore subsurface oceans on icy worlds, and see a JPL team testing a prototype at a pool at Caltech in Pasadena, California, in September 2024. NASA/JPL-Caltech “People might ask, why is NASA developing an underwater robot for space exploration? It’s because there are places we want to go in the solar system to look for life, and we think life needs water. So we need robots that can explore those environments — autonomously, hundreds of millions of miles from home,” said Ethan Schaler, principal investigator for SWIM at NASA’s Jet Propulsion Laboratory in Southern California.
      Under development at JPL, a series of prototypes for the SWIM concept recently braved the waters of a 25-yard (23-meter) competition swimming pool at Caltech in Pasadena for testing. The results were encouraging.
      SWIM Practice
      The SWIM team’s latest iteration is a 3D-printed plastic prototype that relies on low-cost, commercially made motors and electronics. Pushed along by two propellers, with four flaps for steering, the prototype demonstrated controlled maneuvering, the ability to stay on and correct its course, and a back-and-forth “lawnmower” exploration pattern. It managed all of this autonomously, without the team’s direct intervention. The robot even spelled out “J-P-L.”
      Just in case the robot needed rescuing, it was attached to a fishing line, and an engineer toting a fishing rod trotted alongside the pool during each test. Nearby, a colleague reviewed the robot’s actions and sensor data on a laptop. The team completed more than 20 rounds of testing various prototypes at the pool and in a pair of tanks at JPL.
      “It’s awesome to build a robot from scratch and see it successfully operate in a relevant environment,” Schaler said. “Underwater robots in general are very hard, and this is just the first in a series of designs we’d have to work through to prepare for a trip to an ocean world. But it’s proof that we can build these robots with the necessary capabilities and begin to understand what challenges they would face on a subsurface mission.”
      Swarm Science
      A model of the final envisioned SWIM robot, right, sits beside a capsule holding an ocean-composition sensor. The sensor was tested on an Alaskan glacier in July 2023 through a JPL-led project called ORCAA (Ocean Worlds Reconnaissance and Characterization of Astrobiological Analogs). The wedge-shaped prototype used in most of the pool tests was about 16.5 inches (42 centimeters) long, weighing 5 pounds (2.3 kilograms). As conceived for spaceflight, the robots would have dimensions about three times smaller — tiny compared to existing remotely operated and autonomous underwater scientific vehicles. The palm-size swimmers would feature miniaturized, purpose-built parts and employ a novel wireless underwater acoustic communication system for transmitting data and triangulating their positions.
      Digital versions of these little robots got their own test, not in a pool but in a computer simulation. In an environment with the same pressure and gravity they would likely encounter on Europa, a virtual swarm of 5-inch-long (12-centimeter-long) robots repeatedly went looking for potential signs of life. The computer simulations helped determine the limits of the robots’ abilities to collect science data in an unknown environment, and they led to the development of algorithms that would enable the swarm to explore more efficiently.
      The simulations also helped the team better understand how to maximize science return while accounting for tradeoffs between battery life (up to two hours), the volume of water the swimmers could explore (about 3 million cubic feet, or 86,000 cubic meters), and the number of robots in a single swarm (a dozen, sent in four to five waves).
      In addition, a team of collaborators at Georgia Tech in Atlanta fabricated and tested an ocean composition sensor that would enable each robot to simultaneously measure temperature, pressure, acidity or alkalinity, conductivity, and chemical makeup. Just a few millimeters square, the chip is the first to combine all those sensors in one tiny package.
      Of course, such an advanced concept would require several more years of work, among other things, to be ready for a possible future flight mission to an icy moon. In the meantime, Schaler imagines SWIM robots potentially being further developed to do science work right here at home: supporting oceanographic research or taking critical measurements underneath polar ice.
      More About SWIM
      Caltech manages JPL for NASA. JPL’s SWIM project was supported by Phase I and II funding from NASA’s Innovative Advanced Concepts (NIAC) program under the agency’s Space Technology Mission Directorate. The program nurtures visionary ideas for space exploration and aerospace by funding early-stage studies to evaluate technologies that could transform future NASA missions. Researchers across U.S. government, industry, and academia can submit proposals.
      How the SWIM concept was developed Learn about underwater robots for Antarctic climate science See NASA’s network of ready-to-roll mini-Moon rovers News Media Contact
      Melissa Pamer
      Jet Propulsion Laboratory, Pasadena, Calif.
      626-314-4928
      melissa.pamer@jpl.nasa.gov
      2024-162
      Share
      Details
      Last Updated Nov 20, 2024 Related Terms
      Europa Jet Propulsion Laboratory NASA Innovative Advanced Concepts (NIAC) Program Ocean Worlds Robotics Space Technology Mission Directorate Technology Explore More
      5 min read Making Mars’ Moons: Supercomputers Offer ‘Disruptive’ New Explanation
      Article 1 hour ago 4 min read From Houston to the Moon: Johnson’s Thermal Vacuum Chamber Tests Lunar Solar Technology 
      Article 19 hours ago 3 min read Northwestern University Takes Top Honors in BIG Idea Lunar Inflatables Challenge 
      Article 23 hours ago Keep Exploring Discover Related Topics
      Missions
      Humans in Space
      Climate Change
      Solar System
      View the full article
  • Check out these Videos

×
×
  • Create New...