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Advancing Human Spaceflight Safety
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By NASA
Credit: NASA NASA has selected ARES Technical Services of McLean, Virginia, to provide safety and mission assurance services at the agency’s Goddard Space Flight Center in Greenbelt, Maryland, and Wallops Flight Facility in Virginia.
The Safety and Mission Assurance Services III contract is a cost-plus-fixed-fee contract with an estimated total value of $226 million. The contract will have a five-year effective ordering period starting on June 1, 2025, with an optional six-month extension period.
Under the contract, the vendor will provide support to the agency’s Safety and Mission Assurance Directorate at NASA Goddard. This includes performing independent surveillance, audits, reviews, and assessments of design, development, test, and mission operations activities on site at NASA and supplier facilities.
For information about NASA and other agency programs, visit:
https://www.nasa.gov
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Tiernan Doyle
Headquarters, Washington
202-358-1600
tiernan.doyle@nasa.gov
Jacob Richmond
Goddard Space Flight Center, Maryland
301-286-6255
jacob.a.richmond@nasa.gov
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Last Updated Apr 07, 2025 LocationNASA Headquarters Related Terms
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By NASA
NASA has selected 12 student teams to develop solutions for storing and transferring the super-cold liquid propellants needed for future long-term exploration beyond Earth orbit.
The agency’s 2025 Human Lander Challenge is designed to inspire and engage the next generation of engineers and scientists as NASA and its partners prepare to send astronauts to the Moon through the Artemis campaign in preparation for future missions to Mars. The commercial human landing systems will serve as the primary mode of transportation that will safely take astronauts and, later, large cargo from lunar orbit to the surface of the Moon and back.
For its second year, the competition invites university students and their faculty advisors to develop innovative, “cooler” solutions for in-space cryogenic, or super cold, liquid propellant storage and transfer systems. These cryogenic fluids, like liquid hydrogen or liquid oxygen, must stay extremely cold to remain in a liquid state, and the ability to effectively store and transfer them in space will be increasingly vital for future long-duration missions. Current technology allows cryogenic liquids to be stored for a relatively short amount of time, but future missions will require these systems to function effectively over several hours, weeks, and even months.
The 12 selected finalists have been awarded a $9,250 development stipend to further develop their concepts in preparation for the next stage of the competition.
The 2025 Human Lander Challenge finalist teams are:
California State Polytechnic University, Pomona, “THERMOSPRING: Thermal Exchange Reduction Mechanism using Optimized SPRING” Colorado School of Mines, “MAST: Modular Adaptive Support Technology” Embry-Riddle Aeronautical University, “Electrical Capacitance to High-resolution Observation (ECHO)” Jacksonville University, “Cryogenic Complex: Cryogenic Tanks and Storage Systems – on the Moon and Cislunar Orbit” Jacksonville University, “Cryogenic Fuel Storage and Transfer: The Human Interface – Monitoring and Mitigating Risks” Massachusetts Institute of Technology, “THERMOS: Translunar Heat Rejection and Mixing for Orbital Sustainability” Old Dominion University, “Structural Tensegrity for Optimized Retention in Microgravity (STORM)” Texas A&M University, “Next-generation Cryogenic Transfer and Autonomous Refueling (NeCTAR)” The College of New Jersey, “Cryogenic Orbital Siphoning System (CROSS)” The Ohio State University, “Autonomous Magnetized Cryo-Couplers with Active Alignment Control for Propellant Transfer (AMCC-AAC) University of Illinois, Urbana-Champaign, “Efficient Cryogenic Low Invasive Propellant Supply Exchange (ECLIPSE)” Washington State University, “CRYPRESS Coupler for Liquid Hydrogen Transfer” Finalist teams will now work to submit a technical paper further detailing their concepts. They will present their work to a panel of NASA and industry judges at the 2025 Human Lander Competition Forum in Huntsville, Alabama, near NASA’s Marshall Space Flight Center, in June 2025. The top three placing teams will share a total prize purse of $18,000.
“By engaging college students in solving critical challenges in cryogenic fluid technologies and systems-level solutions, NASA fosters a collaborative environment where academic research meets practical application,” said Tiffany Russell Lockett, office manager for the Human Landing System Mission Systems Management Office at NASA Marshall. “This partnership not only accelerates cryogenics technology development but also prepares the Artemis Generation – the next generation of engineers and scientists – to drive future breakthroughs in spaceflight.”
NASA’s Human Lander Challenge is sponsored by the agency’s Human Landing System Program within the Exploration Systems Development Mission Directorate and managed by the National Institute of Aerospace.
For more information on NASA’s 2025 Human Lander Challenge, including team progress, visit the challenge website.
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Corinne Beckinger
Marshall Space Flight Center, Huntsville, Ala.
256.544.0034
corinne.m.beckinger@nasa.gov
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
A Massachusetts Institute of Technology Lincoln Laboratory pilot controls a drone during NASA’s In-Time Aviation Safety Management System test series in collaboration with a George Washington University team July 17-18, 2024, at the U.S. Army’s Fort Devens in Devens, Massachusetts. MIT Lincoln Laboratory/Jay Couturier From agriculture and law enforcement to entertainment and disaster response, industries are increasingly turning to drones for help, but the growing volume of these aircraft will require trusted safety management systems to maintain safe operations.
NASA is testing a new software system to create an improved warning system – one that can predict hazards to drones before they occur. The In-Time Aviation Safety Management System (IASMS) will monitor, assess, and mitigate airborne risks in real time. But making sure that it can do all that requires extensive experimentation to see how its elements work together, including simulations and drone flight tests.
“If everything is going as planned with your flight, you won’t notice your in-time aviation safety management system working,” said Michael Vincent, NASA acting deputy project manager with the System-Wide Safety project at NASA’s Langley Research Center in Hampton, Virginia. “It’s before you encounter an unusual situation, like loss of navigation or communications, that the IASMS provides an alert to the drone operator.”
The team completed a simulation in the Human-Autonomy Teaming Laboratory at NASA’s Ames Research Center in California’s Silicon Valley on March 5 aimed at finding out how critical elements of the IASMS could be used in operational hurricane relief and recovery.
During this simulation, 12 drone pilots completed three 30-minute sessions where they managed up to six drones flying beyond visual line of sight to perform supply drops to residents stranded after a severe hurricane. Additional drones flew scripted search and rescue operations and levee inspections in the background. Researchers collected data on pilot performance, mission success, workload, and perceptions of the experiences, as well as the system’s usability.
This simulation is part of a longer-term strategy by NASA to advance this technology. The lessons learned from this study will help prepare for the project’s hurricane relief and recovery flight tests, planned for 2027.
As an example of this work, in the summer of 2024 NASA tested its IASMS during a series of drone flights in collaboration with the Ohio Department of Transportation in Columbus, Ohio, and in a separate effort, with three university-led teams.
For the Ohio Department of Transportation tests, a drone flew with the NASA-developed IASMS software aboard, which communicated back to computers at NASA Langley. Those transmissions gave NASA researchers input on the system’s performance.
Students from the Ohio State University participate in drone flights during NASA’s In-Time Aviation Safety Management System test series in collaboration with the Ohio Department of Transportation from March to July 2024 at the Columbus Aero Club in Ohio. NASA/Russell Gilabert NASA also conducted studies with The George Washington University (GWU), the University of Notre Dame, and Virginia Commonwealth University (VCU). These occurred at the U.S. Army’s Fort Devens in Devens, Massachusetts with GWU; near South Bend, Indiana with Notre Dame; and in Richmond, Virginia with VCU. Each test included a variety of types of drones, flight scenarios, and operators.
Students from Virginia Commonwealth University walk toward a drone after a flight as part of NASA’s In-Time Aviation Safety Management System (IASMS) test series July 16, 2024, in Richmond, Virginia. NASA/Dave Bowman Each drone testing series involved a different mission for the drone to perform and different hazards for the system to avoid. Scenarios included, for example, how the drone would fly during a wildfire or how it would deliver a package in a city. A different version of the NASA IASMS was used to fit the scenario depending on the mission, or depending on the flight area.
Students from the University of Notre Dame prepare a small drone for takeoff as part of NASA’s In-Time Aviation Safety Management System (IASMS) university test series, which occurred on August 21, 2024 in Notre Dame, Indiana.University of Notre Dame/Wes Evard When used in conjunction with other systems such as NASA’s Unmanned Aircraft System Traffic Management, IASMS may allow for routine drone flights in the U.S. to become a reality. The IASMS adds an additional layer of safety for drones, assuring the reliability and trust if the drone is flying over a town on a routine basis that it remains on course while avoiding hazards along the way.
“There are multiple entities who contribute to safety assurance when flying a drone,” Vincent said. “There is the person who’s flying the drone, the company who designs and manufactures the drone, the company operating the drone, and the Federal Aviation Administration, who has oversight over the entire National Airspace System. Being able to monitor, assess and mitigate risks in real time would make the risks in these situations much more secure.”
All of this work is led by NASA’s System-Wide Safety project under the Airspace Operations and Safety program in support of the agency’s Advanced Air Mobility mission, which seeks to deliver data to guide the industry’s development of electric air taxis and drones.
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Last Updated Apr 02, 2025 EditorDede DiniusContactTeresa Whitingteresa.whiting@nasa.gov Related Terms
Advanced Air Mobility Aeronautics Research Mission Directorate Airspace Operations and Safety Program Ames Research Center Armstrong Flight Research Center Drones & You Flight Innovation Langley Research Center System-Wide Safety Explore More
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
In-person participants (L-R) – Back row: Jason Lytle, Stuart Lee, Eric Bershad, Ashot Sargsyan, Aaron Everson, Philip Wells, Sergi Vaquer Araujo, Steven Grover, John A. Heit, Mehdi Shishehbor, Laura Bostick; Middle row: Sarah Childress Taoufik, Stephan Moll, Brandon Macias, Kristin Coffey, Ann-Kathrin Vlacil, Dave Francisco; Front row: James Pavela, Doug Ebert, Kathleen McMonigal, Esther Kim, Emma Hwang; Not pictured: Tyson Brunstetter, J. D. Polk
Online participants: Stephen Alamo, Mark Crowther, Steven Nissen, Mark Rosenberg, Jeffrey Weitz, R. Eugene Zierler, Serena Aunon, Tina Bayuse, Laura Beachy, Becky Brocato, Daniel Buckland, Jackie Charvat, Diana Cruz Topete, Quinn Dufurrena, Robert Haddon, Joanne Kaouk, Kim Lowe, Steve Laurie, Karina Marshall-Goebel, Sara Mason, Shannan Moynihan, James Pattarini, Devan Petersen, Ruth Reitzel, Donna Roberts, Lucia Roccaro, Mike Stenger, Terry Taddeo, Gavin Travers, Mary Van Baalen, Liz WarrenNASA In October 2024, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review the status and progress of research and clinical activities intended to mitigate the risk of venous thromboembolism (VTE) during spaceflight. The working group took place over two days at NASA’s Johnson Space Center; a second meeting on the topic was held in December 2024 at the European Space Agency (ESA) facility in Cologne, Germany.
Read More about the Risk of VTE The working group was assembled from internal NASA subject matter experts (SMEs), the NASA OCHMO Standards Team, NASA and ESA stakeholders, and external SMEs, including physicians and medical professionals from leading universities and medical centers in the United States and Canada.
Background
Spaceflight Venous Thrombosis (SVT)
Spaceflight Venous Thrombosis (SVT) refers to a phenomenon experienced during spaceflight in which a thrombus (blood clot) forms in the internal jugular vein (and/or associated vasculature) that may be symptomatic (thrombus accompanied by, but not limited to, visible internal jugular vein swelling, facial edema beyond “nominal” spaceflight adaptation, eyelid edema, and/or headache) or asymptomatic. Obstructive thrombi have been identified in a very small number of crewmembers, as shown in the figure below.
Note that the figure below is for illustrative purposes only; locations are approximate, and size is not to scale.
Approximate location of identified thrombi in crewmembers.Source: Modified from Cerebral Sinus Venous Thrombosis – University of Colorado Denver With treatment, crewmembers were able to complete their mission, and anticoagulants were discontinued several days prior to landing to minimize the risk of bleeding in the event of a traumatic injury. Some thromboses completely resolved post landing, and some required additional treatment.
Pathophysiology of Venous Thromboembolism (VTE)
The proposed pathogenesis of VTE is referred to as Virchow’s triad and suggests that VTE occurs as the result of:
Alterations in blood flow (i.e., stasis), Vascular endothelial injury/changes, and/or, Alterations in the constituents of the blood leading to hypercoagulability (i.e., hereditary predisposition or acquired hypercoagulability). Note: pathophysiology are the changes that occur during a disease process; hypercoagulability is the increased tendency to develop blood to clots.
The Virchow’s triad of risk factors for venous thrombosis.Bouchnita, 2017 Blood stasis, or venous stasis, refers to a condition in which the blood flow in the veins slows down which leads to pooling in the veins. This slowing of the blood may be due to vein valves becoming damaged or weak, immobility, and/or the absence of muscular contractions. Associated symptoms include swelling, skin changes, varicose veins, and slow-healing sores or ulcers. In terrestrial medicine, venous thrombosis is typically caused by damaged or weakened vein valves, which can be due to many factors, including aging, blood clots, varicose veins, obesity, pregnancy, sedentary lifestyle, estrogen use, and hereditary predisposition.
Spaceflight Considerations
Altered Venous Blood Flow and Spaceflight Associated Neuro-ocular Syndrome
In addition to the terrestrial risk factors of VTE, there are physiological changes associated with spaceflight that are hypothesized to potentially play a role in the development of VTE in weightlessness. Specifically, researchers have explored the effects of the microgravity environment and subsequent observed headward fluid shifts that occur, and the potential impact on blood flow. Crewmembers onboard the International Space Station (ISS) experience weightlessness due to the microgravity environment and thus experience a sustained redistribution of bodily fluids from the legs toward the head. The prolonged headward fluid shifts during weightlessness results in facial puffiness, decreased leg volume, increased cardiac stroke volume, and decreased plasma volume.
Crewmembers have also experienced altered blood flow during spaceflight, including retrograde venous blood flow (RVBF) (the backflow of venous blood towards the brain) or stasis (a stoppage or slowdown in the flow of blood). While the causes of the observed stasis and retrograde blood flow in spaceflight participants is not well understood, the potential clinical significance of the role it may have in the development of thrombus formation warrants further investigation.
Doppler imaging of a retrograde flow in the left internal jugular vein.Yan & Seow, 2009 Other physiological concerns affected by fluid shifts are being studied to consider if any relation to VTE exists. Chronic weightlessness can cause bodily fluids such as blood and cerebrospinal fluid to move toward the head, which can lead to optic nerve swelling, folds in the retina, flattening of the back of the eye, and swelling in the brain. This collection of eye and brain changes is called “spaceflight associated neuro-ocular syndrome,” or SANS. Some astronauts only experience mild changes in space, while others have clinically significant outcomes. The long-term health outcome from these changes is unknown but actively being investigated. The risk of developing SANS is higher during longer-duration missions and remains a top research priority for scientists ahead of a Mars mission.
Conclusions and Further Work
Based on expert opinion and the assessment of the risk factors for thrombosis, an algorithm was developed to provide guidance for in-mission assessment and treatment of thrombus formation in weightlessness. The algorithm is based on early in-flight ultrasound testing to determine the flow characteristic of the left internal jugular vein and associated vasculature.
NASA Working Group Recommendations
The working group recommended several areas for further investigation to assess feasibility and potential to mitigate the risk of thrombosis in spaceflight:
Improved detection capabilities to identify when a thrombus has formed in-flight, Pathophysiology/factors leading to thrombi formation during spaceflight, Countermeasures and treatment
For more information on the working group meeting and a complete list of references, please see the Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report.
Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report Share
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Last Updated Mar 14, 2025 EditorKim Lowe Related Terms
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By NASA
Center Director Dr. Jimmy Kenyon gives an overview of NASA Glenn Research Center’s areas of expertise and how it supports the agency’s missions and programs. Credit: NASA/Susan Valerian NASA Glenn Research Center’s Director Dr. Jimmy Kenyon and Chief Counsel Callista Puchmeyer participated in a local symposium that addressed the operational and legal challenges of human spaceflight. The one-day conference was held at the Cleveland State University (CSU) College of Law on Feb.13.
Kenyon gave a keynote that provided an overview of NASA Glenn’s areas of expertise and how the center supports the agency’s missions and programs. He also talked about the role of growing commercial partnerships at NASA.
Panelists, left to right: Col. (Ret.) Joseph Zeis, senior advisor for Aerospace and Defense, Office of the Governor of Ohio; Callista Puchmeyer, chief counsel, NASA’s Glenn Research Center; and Jon. P. Yormick, international business and trade attorney, Yormick Law, answer questions on operational and legal challenges of human spaceflight at a Cleveland State University College of Law symposium. Credit: NASA/Susan Valerian Puchmeyer, a graduate of CSU’s College of Law and recent inductee into its Hall of Fame, participated in a panel about Northeast Ohio’s aerospace industry and the legal aspects of commercial partnerships.
Additionally, human spaceflight experts from academia, law, and science spoke throughout the day on topics ranging from the health and training of astronauts to the special law of space stations. Romanian astronaut Dumitru-Dorin Prunariu joined remotely to provide a personal perspective.
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