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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The mystery of why life uses molecules with specific orientations has deepened with a NASA-funded discovery that RNA — a key molecule thought to have potentially held the instructions for life before DNA emerged — can favor making the building blocks of proteins in either the left-hand or the right-hand orientation. Resolving this mystery could provide clues to the origin of life. The findings appear in research recently published in Nature Communications.
Proteins are the workhorse molecules of life, used in everything from structures like hair to enzymes (catalysts that speed up or regulate chemical reactions). Just as the 26 letters of the alphabet are arranged in limitless combinations to make words, life uses 20 different amino acid building blocks in a huge variety of arrangements to make millions of different proteins. Some amino acid molecules can be built in two ways, such that mirror-image versions exist, like your hands, and life uses the left-handed variety of these amino acids. Although life based on right-handed amino acids would presumably work fine, the two mirror images are rarely mixed in biology, a characteristic of life called homochirality. It is a mystery to scientists why life chose the left-handed variety over the right-handed one.
A diagram of left-handed and right-handed versions of the amino acid isovaline, found in the Murchison meteorite.NASA DNA (deoxyribonucleic acid) is the molecule that holds the instructions for building and running a living organism. However, DNA is complex and specialized; it “subcontracts” the work of reading the instructions to RNA (ribonucleic acid) molecules and building proteins to ribosome molecules. DNA’s specialization and complexity lead scientists to think that something simpler should have preceded it billions of years ago during the early evolution of life. A leading candidate for this is RNA, which can both store genetic information and build proteins. The hypothesis that RNA may have preceded DNA is called the “RNA world” hypothesis.
If the RNA world proposition is correct, then perhaps something about RNA caused it to favor building left-handed proteins over right-handed ones. However, the new work did not support this idea, deepening the mystery of why life went with left-handed proteins.
The experiment tested RNA molecules that act like enzymes to build proteins, called ribozymes. “The experiment demonstrated that ribozymes can favor either left- or right-handed amino acids, indicating that RNA worlds, in general, would not necessarily have a strong bias for the form of amino acids we observe in biology now,” said Irene Chen, of the University of California, Los Angeles (UCLA) Samueli School of Engineering, corresponding author of the Nature Communications paper.
In the experiment, the researchers simulated what could have been early-Earth conditions of the RNA world. They incubated a solution containing ribozymes and amino acid precursors to see the relative percentages of the right-handed and left-handed amino acid, phenylalanine, that it would help produce. They tested 15 different ribozyme combinations and found that ribozymes can favor either left-handed or right-handed amino acids. This suggested that RNA did not initially have a predisposed chemical bias for one form of amino acids. This lack of preference challenges the notion that early life was predisposed to select left-handed-amino acids, which dominate in modern proteins.
“The findings suggest that life’s eventual homochirality might not be a result of chemical determinism but could have emerged through later evolutionary pressures,” said co-author Alberto Vázquez-Salazar, a UCLA postdoctoral scholar and member of Chen’s research group.
Earth’s prebiotic history lies beyond the oldest part of the fossil record, which has been erased by plate tectonics, the slow churning of Earth’s crust. During that time, the planet was likely bombarded by asteroids, which may have delivered some of life’s building blocks, such as amino acids. In parallel to chemical experiments, other origin-of-life researchers have been looking at molecular evidence from meteorites and asteroids.
“Understanding the chemical properties of life helps us know what to look for in our search for life across the solar system,” said co-author Jason Dworkin, senior scientist for astrobiology at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, and director of Goddard’s Astrobiology Analytical Laboratory.
Dworkin is the project scientist on NASA’s OSIRIS-REx mission, which extracted samples from the asteroid Bennu and delivered them to Earth last year for further study.
“We are analyzing OSIRIS-REx samples for the chirality (handedness) of individual amino acids, and in the future, samples from Mars will also be tested in laboratories for evidence of life including ribozymes and proteins,” said Dworkin.
The research was supported by grants from NASA, the Simons Foundation Collaboration on the Origin of Life, and the National Science Foundation. Vázquez-Salazar acknowledges support through the NASA Postdoctoral Program, which is administered by Oak Ridge Associated Universities under contract with NASA.
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Last Updated Nov 21, 2024 EditorWilliam SteigerwaldContactNancy N. Jonesnancy.n.jones@nasa.govLocationGoddard Space Flight Center Related Terms
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By European Space Agency
As Arctic temperatures rise, marine-terminating glaciers—especially in places like Svalbard—are undergoing rapid retreat and intensified calving.
The ESA-funded Space for Shore project utilises radar data from the Copernicus Sentinel-1 mission to provide precise, year-over-year insights into glacier retreat and calving intensity, particularly in areas like Kongsfjorden, where notable glaciers are experiencing significant retreat.
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By NASA
Credit: NASA NASA, on behalf of the National Oceanic and Atmospheric Administration (NOAA), has selected Southwest Research Institute of San Antonio to build three coronagraphs for the Lagrange 1 Series project, part of NOAA’s Space Weather Next program.
Once operational, the coronagraphs will provide critical data to NOAA’s Space Weather Prediction Center, which issues forecasts, warnings, and alerts that help mitigate space weather impacts, including electric power outages and interruption to communications and navigation systems.
This cost-plus-fixed-fee contract is valued at approximately $60 million, and the anticipated period of performance is from this November through January 2034, concluding after launch of the second coronagraph aboard a NOAA spacecraft. The third coronagraph will be delivered as a flight spare.
This contract award marks a transfer of coronagraph development from the government to the U.S. commercial sector. The contract scope includes design, analysis, development, fabrication, integration, test, verification, and evaluation of the coronagraphs; launch support; supply and maintenance of ground support equipment; and support of post-launch instrument operations at the NOAA Satellite Operations Facility. The work will take place at Southwest Research Institute’s facility in San Antonio.
The coronagraphs will observe the density structure of the Sun’s faint outermost atmosphere — the corona — and will detect Earth-directed coronal mass ejections shortly after they erupt, providing the longest possible lead time for geomagnetic storm watches. With this forewarning, public and private organizations affected by space weather can take actions to protect their assets. The coronagraphs will also provide data continuity from the Space Weather follow-on Lagrange 1 mission.
NASA and NOAA oversee the development, launch, testing and operation of all the satellites in the project. NOAA is the program owner providing the requirements and funding along with managing the program, operations, data products, and dissemination to users. NASA and its commercial partners develop and build the instruments, spacecraft, and provide launch services on behalf of NOAA.
For information about NASA and agency programs, visit:
https://www.nasa.gov
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Abbey Donaldson
Headquarters, Washington
202-358-1600
Abbey.a.donaldson@nasa.gov
Jeremy Eggers
Goddard Space Flight Center, Greenbelt, Md.
757-824-2958
jeremy.l.eggers@nasa.gov
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By NASA
MuSat2 at Vandenberg Air Force Base, prior to launch. MuSat2 leverages a dual-frequency science antenna developed with support from NASA to measure phenomena such as ocean wind speed. Muon Space A science antenna developed with support from NASA’s Earth Science Technology Office (ESTO) is now in low-Earth orbit aboard MuSat2, a commercial remote-sensing satellite flown by the aerospace company Muon Space. The dual-frequency science antenna was originally developed as part of the Next Generation GNSS Bistatic Radar Instrument (NGRx). Aboard MuSat2, it will help measure ocean surface wind speed—an essential data point for scientists trying to forecast how severe a burgeoning hurricane will become.
“We’re very interested in adopting this technology and pushing it forward, both from a technology perspective and a product perspective,” said Jonathan Dyer, CEO of Muon.
Using this antenna, MuSat2 will gather signals transmitted by navigation satellites as they scatter off Earth’s surface and back into space. By recording how those scattered navigation signals change as they interact with Earth’s surface, MuSat2 will provide meteorologists with data points they can use to study severe weather.
“We use the standard GPS signals you know—the navigation signals that work for your car and your cell phone,” explained Chris Ruf, director of the University of Michigan Space Institute and principal investigator for NGRx.
Ruf designed the entire NGRx system to be an updated version of the sensors on NASA’s Cyclone Global Navigation Satellite System (CYGNSS), another technology he developed with support from ESTO. Since 2016, data from CYGNSS has been a critical resource for people dedicated to forecasting hurricanes.
The science antenna aboard MuSat2 enables two key improvements to the original CYGNSS design. First, the antenna allows MuSat2 to gather measurements from satellites outside the U.S.-based GPS system, such as the European Space Agency’s Galileo satellites. This capability enables MuSat2 to collect more data as it orbits Earth, improving its assessments of conditions on the planet’s surface.
Second, whereas CYGNSS only collected cross-polar radar signals, the updated science antenna also collects co-polar radar signals. This additional information could provide improved information about soil moisture, sea ice, and vegetation. “There’s a whole lot of science value in looking at both polarization components scattering from the Earth’s surface. You can separate apart the effects of vegetation from the effects of surface, itself,” explained Ruf.
Hurricane Ida, as seen from the International Space Station. NASA-developed technology onboard MuSat2 will help supply the U.S. Air Force with critical data for producing reliable weather forecasts. NASA For Muon Space, this technology infusion has been helpful to the company’s business and science missions. Dallas Masters, Vice President of Muon’s Signals of Opportunity Program, explains that NASA’s investments in NGRx technology made it much easier to produce a viable commercial remote sensing satellite. According to Masters, “NGRx-derived technology allowed us to start planning a flight mission early in our company’s existence, based around a payload we knew had flight heritage.”
Dyer agrees. “The fact that ESTO proves out these measurement approaches – the technology and the instrument, the science that you can actually derive, the products from that instrument – is a huge enabler for companies like ours, because we can adopt it knowing that much of the physics risk has been retired,” he said.
Ultimately, this advanced antenna technology for measuring ocean surface wind speed will make it easier for researchers to turn raw data into actionable science products and to develop more accurate forecasts.
“Information is absolutely precious. When it comes to forecast models and trying to understand what’s about to happen, you have to have as good an idea as you can of what’s already happening in the real world,” said oceanographer Lew Gramer, an Associate Scientist with the Cooperative Institute For Marine And Atmospheric Studies and NOAA’s Hurricane Research Division.
Project Lead: Chris Ruf, University of Michigan
Sponsoring Organizations: NASA’s Earth Science Technology Office and Muon Space
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Last Updated Nov 12, 2024 Related Terms
CYGNSS (Cyclone Global Navigation Satellite System) Earth Science Earth Science Division Earth Science Technology Office Oceans Science-enabling Technology Technology Highlights Explore More
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