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By NASA
Researchers demonstrated the feasibility of 3D bioprinting a meniscus or knee cartilage tissue in microgravity. This successful result advances technology for bioprinting tissue to treat musculoskeletal injuries on long-term spaceflight or in extraterrestrial settings where resources and supply capacities are limited.
BFF Meniscus-2 evaluated using the BioFabrication Facility to 3D print knee cartilage tissue using bioinks and cells. The meniscus is the first engineered tissue of an anatomically relevant shape printed on the station. Manufactured human tissues have potential as alternatives to donor organs, which are in short supply. Bioprinting in microgravity overcomes some of the challenges present in Earth’s gravity, such as deformation or collapse of tissue structures.
A human knee meniscus 3D bioprinted in space using the International Space Station’s BioFabrication Facility.Redwire Complex cultures of central nervous system cells known as brain organoids can be maintained in microgravity for long periods of time and show faster development of neurons than cultures on Earth. These findings could help researchers develop treatments for neurodegenerative diseases on Earth and address potential adverse neurological effects of spaceflight.
Cosmic Brain Organoids examined growth and gene expression in 3D organoids created with neural stem cells from individuals with primary progressive multiple sclerosis and Parkinson’s disease. Results could improve understanding of these neurological diseases and support development of new treatments. Researchers plan additional studies on the underlying causes of the accelerated neuron maturation.
Neural growth in brain organoids that spent more than a month in space. Jeanne Frances Loring, National Stem Cell Foundation Researchers demonstrated that induced pluripotent stem cells (iPSCs) can be processed in microgravity using off the-shelf cell culture materials. Using standard laboratory equipment and protocols could reduce costs and make space-based biomedical research accessible to a broader range of scientists and institutions.
Stellar Stem Cells Ax-2 evaluated how microgravity affects methods used to generate and grow stem cells into a variety of tissue types on the ground. iPSCs can give rise to any type of cell or tissue in the human body, and insight into processing in space could support their use in regenerative medicine and future large-scale biomanufacturing of cellular therapeutics in space.
NASA astronaut Peggy Whitson, an Axiom Mission 2 crew member, works on stem cell research on a previous mission. NASA/Shane KimbroughView the full article
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By NASA
Successfully deployed from the space shuttle Challenger during the February 1984 STS-41B mission, the Westar 6 and Palapa B2 communications satellites ended up in incorrect orbits due to failures of their upper stage rockets. During STS-51A in November 1984, Discovery’s second trip into space, the crew of Commander Frederick H. “Rick” Hauck, Pilot David M. Walker, and Mission Specialists Joseph P. Allen, Anna L. Fisher, and Dale A. Gardner worked as a team to not only deploy two new satellites but also to retrieve the two wayward but otherwise healthy satellites for return to Earth. Hauck and Walker piloted Discovery to rendezvous with each satellite in turn, Allen and Gardner retrieved them during two spacewalks, and Fisher grappled and placed them in the payload bay for return to Earth. After refurbishment, both satellites returned to space.
Left: The STS-51A crew of Dale A. Gardner, left, David M. Walker, Anna L. Fisher, Frederick “Rick” H. Hauck, and Joseph P. Allen. Right: The STS-51A crew patch.
NASA originally designated Hauck, Walker, Allen, Fisher, and Gardner as a crew in November 1983 and assigned them to STS-41H, a mission aboard Challenger planned for late September 1984 to either deploy the second Tracking and Data Relay Satellite (TDRS) or fly a classified payload for the Department of Defense. Due to ongoing problems with the Inertial Upper Stage that failed to put the first TDRS satellite in its correct orbit during STS-6, NASA canceled STS-41H and shifted Hauck’s crew to STS-51A. In February 1984, an agreement between NASA and the Canadian government added an as-yet unnamed Canadian payload specialist to the STS-51A crew. Managers later named the Canadian as Marc Garneau and reassigned him to STS-41G.
A shuffling of payloads following the STS-41D launch abort resulted in STS-51A now deploying the Anik D2 satellite for Canada and Leasat 1 (also known as Syncom IV-1) for the U.S. Navy. By early August, the launch date had slipped to Nov. 2, with NASA considering the possibility of retrieving the two wayward satellites from STS-41B, officially adding that task on Aug. 13. NASA selected Allen in 1967 as one of 11 scientist-astronauts, while the rest of the crew hail from the Class of 1978. Hauck, on his second mission after serving as pilot on STS-7, has the distinction as the first from his class to command a shuttle mission. Allen and Gardner had each flown one previous mission, STS-5 and STS-8, respectively, while for Walker and Fisher STS-51A represented their first flight. Fisher has the distinction as the first mother in space.
Left: After its arrival from the Orbiter Processing Facility, workers in the Vehicle Assembly Building (VAB) prepare to lift Discovery for mating with an External Tank (ET) and Solid Rocket Boosters (SRBs). Middle: Workers lift Discovery to stack it with the ET and SRBs. Right: The completed stack prepares to leave the VAB for the rollout to Launch Pad 39A.
Discovery arrived back at NASA’s Kennedy Space Center (KSC) in Florida on Sept. 10, returning from Edwards Air Force Base in California following the STS-41D mission. Workers towed it to the Orbiter Processing Facility (OPF) the next day to begin the process of refurbishing it for STS-51A. On Oct. 18, they rolled it over to the Vehicle Assembly Building (VAB), for stacking with an External Tank and twin Solid Rocket Boosters.
At NASA’s Kennedy Space Center in Florida, space shuttle Discovery rolls out to Launch Pad 39A, with the Saturn V rocket on display in the foreground.
The completed stack rolled out to Launch Pad 39A on Oct. 23. Two days later, the five-member STS-51A crew participated in the Terminal Countdown Demonstration Test, essentially a dress rehearsal for the actual countdown to launch. The crew returned to KSC on Nov. 5, the day the countdown began for a planned Nov. 7 launch. High upper-level winds that day forced a one-day delay.
Left: STS-51A astronaut Dale A. Gardner trains for the capture of a satellite using the Apogee Kick Motor Capture Device. Middle: Astronaut Anna L. Fisher trains to use the Canadian-built Remote Manipulator System, or robotic arm. Right: As part of the Terminal Countdown Demonstration Test, the STS-51A astronauts practice rapid evacuation from the launch pad.
Following deployment from Challenger during STS-41B, the upper stages of both the Westar 6 and Palapa B2 satellites malfunctioned, leaving them in non-useable 160-by-600-mile-high orbits instead of the intended 22,300-mile-high geostationary orbits required for their normal operations. While both satellites remained healthy, their own thrusters could not boost them to the proper orbits. NASA devised a plan to have astronauts retrieve the satellites during spacewalks using the jetpack known as the Manned Maneuvering Unit (MMU), after which the shuttle’s Canadian-built Remote Manipulator System (RMS) or robot arm would grapple them and place them into the cargo bay for return to Earth. Astronauts had demonstrated the capability of the MMU during the STS-41C Solar Max satellite repair mission in April 1984 and NASA felt confident of its ability to capture and return Westar and Palapa.
In the weeks prior to STS-51A, ground controllers lowered the orbits of both satellites and reduced their spin rates from 50 to 1 rpm to enable capture by the shuttle astronauts. Engineers at NASA’s Johnson Space Center in Houston developed the Apogee Kick Motor Capture Device (ACD), otherwise known as the stinger due to its appearance, to allow an astronaut to capture the satellites while flying the MMU. Once relocated over the payload bay, a second astronaut would remove the satellite’s omnidirectional antenna with pruning shears and install an Antenna Bridge Structure (ABS) with a grapple fixture over the satellite’s main antenna dish. Allen would fly the MMU to capture Palapa, then he would switch roles with Gardner who would capture Westar. Fisher would use the RMS to grapple the satellites by this second fixture and lower them into specially built cradles to secure them into the payload bay.
Left: The STS-51A crew leaves crew quarters on their way to Launch Pad 39A. Middle: Liftoff of Discovery on the STS-51A mission. Right: View inside Discovery’s payload bay shortly after orbital insertion – the top of Anik D2 is visible, with Leasat 1 hidden behind it.
Space shuttle Discovery roared off KSC’s Launch Pad 39A on Nov. 8, 1984, to begin the STS-51A mission and mark the orbiter’s first return to space. For Gardner, launch day coincided with his 36th birthday. The launch took place just 26 days after the landing of the previous mission, STS-41G, a then record-breaking turnaround time between shuttle flights. Eight and a half minutes after liftoff, Discovery and its five-member crew reached space and shortly thereafter settled into a 182-by-172-mile-high initial orbit. As their first order of business, the crew checked out the RMS to ensure its functionality for the satellite captures later in the mission. They also performed the first rendezvous burn to begin the approach to the Palapa satellite. The crew then settled down for its first night’s sleep in orbit.
Left: Nighttime deploy of the Anik D2 satellite. Middle: Deploy of the Leasat 1 satellite. Right: Leasat 1 as it departs from Discovery.
The primary activity of the second flight day involved Allen deploying the 2,727-pound Anik D2 satellite via a spring ejection mechanism, occurring on time and with no issues. The crew also circularized the shuttle’s orbit at 186 miles. The next day, Gardner deployed the 17,000-pound Leasat 1 using the Frisbee style mechanism used to deploy the first Leasat during STS-41D two months earlier. With the satellite deployments complete, the crew began to focus on the rendezvous maneuvers to bring them close to the Palapa B2 satellite while Allen and Gardner verified the functionality of their spacesuits. On flight day 4, the astronauts reduced the pressure inside the shuttle from 14.7 pounds per square inch (psi) to 10.2 psi in order to prevent the spacewalking astronauts from developing the bends inside the spacesuits that operated at 4.3 psi.
Left: During the first spacewalk, Jospeh P. Allen captures the Palapa B2 satellite. Middle: Anna L. Fisher grasps Allen and Palapa with the Remote Manipulator System, or robotic arm. Right: Allen, left, and Dale A. Gardner prepare to place Palapa in its cradle in the payload bay.
On the fifth mission day, after Hauck and Walker piloted Discovery to within 35 feet of Palapa, Allen and Gardner exited the airlock to begin the spacewalk portion of the satellite capture. Allen donned the MMU mounted on the side wall of the cargo bay, attached the stinger to its arms, and flew out to Palapa. Once there, he inserted the stinger into the satellite’s Apogee Kick Motor bell and using the MMU’s attitude control system stopped Palapa’s spin.
Fisher then steered the RMS to capture a grapple fixture mounted on the stinger between Allen and the satellite. She then maneuvered them over the payload bay where Gardner waited to remove its omnidirectional antenna and install the bridge structure. However, Gardner could not attach the ABS to the satellite due to an unexpected clearance issue on the satellite. Using a backup plan, Allen undocked from the stinger, leaving it attached to the satellite as well as the RMS, and stowed the MMU in the payload bay. With Allen now holding the satellite by its antenna, Gardner attached an adaptor to the bottom end of the satellite to secure it in its cradle in the payload bay. This plan worked and Allen and Gardner completed the spacewalk in exactly six hours.
Left: Dale A. Gardner flies the Manned Maneuvering Unit to capture Westar 6 during the second spacewalk. Middle: Anna L. Fisher operates the Remote Manipulator System from Discovery’s aft flight deck. Right: Gardner, left, and Joseph P. Allen maneuver Westar prior to placing it in its cradle in the payload bay.
Between the two spacewalk days, the crew serviced the spacesuits, conducted routine maintenance on the shuttle, and prepared for the second rendezvous, this time to retrieve Westar. Allen and Gardner switched roles for the second spacewalk on flight day seven, with Gardner flying the MMU to capture Westar. The astronauts repeated the procedure from the first spacewalk, except for not removing the omni antenna so they could use it as a handhold. With Westar secured in the payload bay, Gardner and Allen completed the second spacewalk in 5 hours and 42 minutes.
Left: Dale A. Gardner, left, and Joseph P. Allen pose at the end of the Remote Manipulator System controlled by Anna L. Fisher, holding a For Sale sign above the two retrieved satellites secured in Discovery’s payload bay. Middle: Inflight photo of the STS-51A crew after the successful satellite retrievals. Right: View inside Discovery’s payload bay shortly before the deorbit burn, with Westar 6 in the foreground and Palapa B2 behind it.
During their final full day in space, Discovery’s crew repressurized the shuttle’s cabin to 14.7 psi and tidied the cabin in preparation for reentry. On Nov. 16, the astronauts closed the payload bay doors and fired the Orbital Maneuvering System engines to begin the descent back to Earth. Hauck guided Discovery to a smooth landing at KSC, completing a flight of 7 days, 23 hours, and 45 minutes. The crew had traveled nearly 3.3 million miles and completed 127 orbits around the Earth. The next day, workers towed Discovery to the OPF to begin preparing it for its next flight, STS-51C in January 1985.
Left: Discovery streaks over Houston on its way to land at NASA’s Kennedy Space Center (KSC) in Florida. Middle: Discovery moments before touchdown at KSC. Right: NASA officials greet the STS-51A astronauts as they exit Discovery.
As a postscript, STS-51A marked the last flight to use the MMUs, and the last untethered spacewalks until 1994 when STS-64 astronauts tested the Simplified Aid for EVA Rescue (SAFER). All subsequent spacewalks on the space shuttle and the International Space Station used safety tethers, with the SAFER as a backup in case a crew member disconnects from the vehicle.
Left: In the Orbiter Processing Facility at NASA’s Kennedy Space Center in Florida, workers inspect the Westar 6, left, and Palapa B2 satellites in Discovery’s payload bay. Right: The STS-51A crew, with Lloyd’s of London representative Stephen Merritt, sitting at right, during their visit to London.
On Dec. 7, 1984, in a ceremony at the White House, President Ronald W. Reagan presented the STS-51A crew with the Lloyd’s of London – the company had insured the two satellites they returned to Earth – Silver Medal for Meritorious Salvage Operations. Fisher has the distinction as only the second woman to receive that award. In February 1985, Lloyd’s flew the crew to London on the Concorde for a week of activities, including addressing the Lloyd’s underwriters and tea with Prince Charles at Kensington Palace.
Hong Kong-based AsiaSat purchased the Westar 6 satellite, refurbished it, and relaunched it as AsiaSat 1 on April 7, 1990, on a Chinese CZ-3 rocket. Title to the Palapa B2 satellite returned to Indonesia after its relaunch as Palapa B2R on April 13, 1990, aboard a Delta rocket.
Read recollections of the STS-51A mission by Hauck, Allen, and Fisher in their oral histories with the JSC History Office. Enjoy the crew’s narration of a video about the STS-51A mission.
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By NASA
Bioprinted patches could help wounds heal
Researchers successfully demonstrated the function of a handheld bioprinter that could provide a simple and effective way to treat wounds in space using human skin cells. Crews could use this technology to treat their own injuries and protect crew health and mission success in the future.
Spaceflight can affect how wounds heal. The Bioprint FirstAid device tested a process for bioprinting a patch to cover a wound and accelerate healing. In the future, a crew member’s own cells may be used to create personalized patches for treating an injury. The bioprinting device is easy to use, can be tailored to specific needs, has a low failure rate, and its mechanics are electronics- and maintenance-free. This ESA (European Space Agency) investigation was coordinated by the German Aerospace Center (DLR).
ESA (European Space Agency) astronaut Matthias Maurer demonstrates the Bioprint FirstAid prototype during preflight training. German Aerospace Center/European Space Agency Countering post-flight proficiency challenges
The day they return from spaceflight, astronauts demonstrate significant impairments in fine motor control and the ability to multitask in simulated flying and driving challenges. This finding could help develop countermeasures so crew members can safely land and conduct early operations on the Moon and Mars.
Manual Control used a battery of tests to examine how spaceflight affects cognitive, sensory, and motor function after landing. Researchers concluded that subtle physiological changes that occur during spaceflight degrade post-flight performance. Subsequent tests showed recovery of performance once exposed to the task, suggesting that simulation training immediately before a task could be an effective countermeasure. Researchers also suggest limiting dual or competing tasks during mission-critical phases.
A simulator used to test crew members’ ability to fly and drive after spaceflight. NASA Gamma-ray telescope resilient to space radiation
Researchers found that the station’s Glowbug gamma-ray telescope could perform in the space radiation environment for multi-year missions. Radiation can affect these types of instruments, but Glowbug regularly detected gamma ray bursts (GRBs) during its one-year operation. Studying GRBs can help scientists better understand the universe and its origins.
Glowbug demonstrated technology to detect and characterize cosmic GRBs, primarily short GRBs, which result from mergers of compact binary star systems containing either two neutron stars or a neutron star and a black hole. Short GRBs produce gravitational waves, ripples in space that travel at the speed of light. Studying these gravitational waves could provide insight into the star systems where they originate and the behavior of matter during the mergers.
Learn more about GRB research here.
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
In Punakha, Bhutan, Dr. Aparna Phalke (left) from SERVIR works with a translator to converse with a local chili farmer (center) about his experiences cultivating these fields for over 30 years– including agricultural management practices, market prices, and farming challenges Sarah Cox/SERVIR NASA and the Kingdom of Bhutan have been actively learning from each other and growing together since 2019. The seeds planted over those years have ripened into improved environmental conservation, community-based natural resource management, and new remote sensing tools.
Known for its governing philosophy of “gross national happiness,” and has a constitutional mandate to maintain at least 60% forest cover. The government’s goals include achieving nationwide food security by 2030.
Bhutan first approached the U.S. State Department to partner on science, technology, engineering, and mathematics (STEM) opportunities for the country, and NASA was invited to help lead these opportunities. In 2019, Bhutan’s King Jigme Khesar Namgyel Wangchuck visited NASA’s Ames Research Center in Silicon Valley, California, and was introduced to several NASA programs.
NASA’s Earth scientists and research staff from several complementary programs have helped support Bhutan’s goals by providing data resources and training to make satellite data more useful to communities and decision makers. Bhutan now uses NASA satellite data in its national land management decisions and plans to foster more geospatial jobs to help address environmental issues.
Supporting Bhutan’s Environmental Decision Makers
Bhutan’s National Land Commission offers tax breaks to farmers to support food security and economic resilience. However, finding and reaching eligible farmers on the ground can be expensive and time consuming, which means small farmers in remote areas can be missed.
A team from SERVIR – a joint NASA-U.S. Agency for International Development initiative – worked with Bhutanese experts to create decision-making tools like the Farm Action Toolkit (FAcT). The tool uses imagery from the NASA-U.S. Geological Survey Landsat satellites to identify and measure the country’s farmland. SERVIR researchers met with agricultural organizations – including Bhutan’s Ministry of Agriculture and Livestock, National Statistics Bureau, and National Center for Organic Agriculture – to adjust the tool for the country’s unique geography and farming practices. The Land Commission now uses FAcT to identify small farms and bring support to more of the country.
NASA also develops local capacity to use Earth data through efforts like the Applied Remote Sensing Training Program (ARSET). In early 2024, ARSET staff worked with SERVIR and Druk Holdings and Investments (DHI) to host a workshop with 46 Bhutanese government personnel. Using tailored local case studies, the teams worked to find ways to better manage natural resources, assist land use planning, and monitor disasters.
“We look forward to continuing this collaboration, as there are still many areas where NASA’s expertise can significantly impact Bhutan’s development goals,” said Manish Rai, an analyst with DHI who helped coordinate the workshop. “This collaboration is a two-way street. While Bhutan has benefited greatly from NASA’s support, we believe there are also unique insights and experiences that Bhutan can share with NASA, particularly in areas like environmental conservation and community-based natural resource management.”
Dr. Aparna Phalke gives a presentation on NASA technology and the SERVIR program to a group of 100 students at the Royal University of Bhutan College of Natural Resources. Sarah Cox/SERVIR Encouraging Bhutan’s Future Environmental Leaders
By working with students and educators from primary schools to the university level, Bhutan and NASA have been investing in the country’s future environmental leadership. Supporting educators and “training trainers” have been pillars of this collaboration.
NASA and Bhutan have worked together to boost the skills of early-career Earth scientists. For example, NASA’s DEVELOP program for undergraduates worked directly with local institutions to create several applied science internships for Bhutanese students studying in the U.S.
Tenzin Wangmo, a high school biology teacher in Bhutan, participated in DEVELOP projects focusing on agriculture and water resources. According to Wangmo, the lessons learned from those projects have been helpful in connecting with her students about STEM opportunities and environmental issues. “Most people only think of NASA as going to space, rather than Earth science,” she said. “It was encouraging to my students that there are lots of opportunities for you if you try.”
NASA is also supporting Bhutan’s future environmental leadership through the GLOBE (Global Learning and Observations to Benefit the Environment) Program. The GLOBE program is a U.S. interagency outreach program that works with teachers to support STEM literacy through hands-on environmental learning. Since 2020, GLOBE has worked through the U.S. State Department and organizations like the Ugyen Wangchuck Institute for Forest Research and Training to support educators at two dozen schools in Bhutan. The program reached more than 650 students with activities like estimating their school’s carbon footprint.
This focus on STEM education enables students and professionals to contribute to Bhutan’s specific development goals now and in the future.
Sonam Tshering, a student who completed two DEVELOP projects on Bhutanese agriculture while studying at the University of Texas at El Paso, was able to share the value of these efforts at the 2023 United Nations Climate Conference. “By applying satellite data from NASA, we aimed to create actionable insights for our local farmers and our policymakers back in Bhutan,” she said.
News Media Contact
Lane Figueroa
Marshall Space Flight Center, Huntsville, Ala.
256.544.0034
lane.e.figueroa@nasa.gov
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Last Updated Nov 04, 2024 Related Terms
SERVIR (Regional Visualization and Monitoring System) Earth Earth Science Earth Science Division Marshall Science Research & Projects Marshall Space Flight Center Explore More
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