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By NASA
A SpaceX Falcon 9 rocket propelled the Dragon spacecraft into orbit carrying NASA astronauts Anne McClain and Nichole Ayers, JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi, and Roscosmos cosmonaut Kirill Peskov. (Credit: NASA) Four crew members of NASA’s SpaceX Crew-10 mission launched at 7:03 p.m. EDT Friday from Launch Complex 39A at NASA’s Kennedy Space Center in Florida for a science expedition aboard the International Space Station.
A SpaceX Falcon 9 rocket propelled the Dragon spacecraft into orbit carrying NASA astronauts Anne McClain and Nichole Ayers, JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi, and Roscosmos cosmonaut Kirill Peskov. The spacecraft will dock autonomously to the forward-facing port of the station’s Harmony module at approximately 11:30 p.m. on Saturday, March 15. Shortly after docking, the crew will join Expedition 72/73 for a long-duration stay aboard the orbiting laboratory.
“Congratulations to our NASA and SpaceX teams on the 10th crew rotation mission under our commercial crew partnership. This milestone demonstrates NASA’s continued commitment to advancing American leadership in space and driving growth in our national space economy,” said NASA acting Administrator Janet Petro. “Through these missions, we are laying the foundation for future exploration, from low Earth orbit to the Moon and Mars. Our international crew will contribute to innovative science research and technology development, delivering benefits to all humanity.”
During Dragon’s flight, SpaceX will monitor a series of automatic spacecraft maneuvers from its mission control center in Hawthorne, California. NASA will monitor space station operations throughout the flight from the Mission Control Center at the agency’s Johnson Space Center in Houston.
NASA’s live coverage resumes at 9:45 p.m., March 15, on NASA+ with rendezvous, docking, and hatching opening. After docking, the crew will change out of their spacesuits and prepare cargo for offload before opening the hatch between Dragon and the space station’s Harmony module around 1:05 a.m., Sunday, March 16. Once the new crew is aboard the orbital outpost, NASA will broadcast welcome remarks from Crew-10 and farewell remarks from the agency’s SpaceX Crew-9 crew, beginning at about 1:40 a.m.
Learn how to watch NASA content through a variety of platforms, including social media.
The number of crew aboard the space station will increase to 11 for a short time as Crew-10 joins NASA astronauts Nick Hague, Suni Williams, Butch Wilmore, and Don Pettit, as well as Roscosmos cosmonauts Aleksandr Gorbunov, Alexey Ovchinin, and Ivan Vagner. Following a brief handover period, Hague, Williams, Wilmore, and Gorbunov will return to Earth no earlier than Wednesday, March 19.Ahead of Crew-9’s departure from station, mission teams will review weather conditions at the splashdown sites off the coast of Florida.
During their mission, Crew-10 is scheduled to conduct material flammability tests to contribute to future spacecraft and facility designs. The crew will engage with students worldwide via the ISS Ham Radio program and use the program’s existing hardware to test a backup lunar navigation solution. The astronauts also will serve as test subjects, with one crew member conducting an integrated study to better understand physiological and psychological changes to the human body to provide valuable insights for future deep space missions.
With this mission, NASA continues to maximize the use of the orbiting laboratory, where people have lived and worked continuously for more than 24 years, testing technologies, performing science, and developing the skills needed to operate future commercial destinations in low Earth orbit and explore farther from our home planet. Research conducted at the space station benefits people on Earth and paves the way for future long-duration missions to the Moon under NASA’s Artemis campaign and beyond.
More about Crew-10
McClain is the commander of Crew-10 and is making her second trip to the orbital outpost since her selection as an astronaut in 2013. She will serve as a flight engineer during Expeditions 72/73 aboard the space station. Follow McClain on X.
Ayers is the pilot of Crew-10 and is flying her first mission. Selected as an astronaut in 2021, Ayers will serve as a flight engineer during Expeditions 72/73. Follow Ayers on X and Instagram.
Onishi is a mission specialist for Crew-10 and is making his second flight to the space station. He will serve as a flight engineer during Expeditions 72/73. Follow Onishi on X.
Peskov is a mission specialist for Crew-10 and is making his first flight to the space station. Peskov will serve as a flight engineer during Expeditions 72/73.
Learn more about NASA’s SpaceX Crew-10 mission and the agency’s Commercial Crew Program at:
https://www.nasa.gov/commercialcrew
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Last Updated Mar 14, 2025 LocationNASA Headquarters Related Terms
Humans in Space International Space Station (ISS) View the full article
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
In-person participants (L-R) – Back row: Jason Lytle, Stuart Lee, Eric Bershad, Ashot Sargsyan, Aaron Everson, Philip Wells, Sergi Vaquer Araujo, Steven Grover, John A. Heit, Mehdi Shishehbor, Laura Bostick; Middle row: Sarah Childress Taoufik, Stephan Moll, Brandon Macias, Kristin Coffey, Ann-Kathrin Vlacil, Dave Francisco; Front row: James Pavela, Doug Ebert, Kathleen McMonigal, Esther Kim, Emma Hwang; Not pictured: Tyson Brunstetter, J. D. Polk
Online participants: Stephen Alamo, Mark Crowther, Steven Nissen, Mark Rosenberg, Jeffrey Weitz, R. Eugene Zierler, Serena Aunon, Tina Bayuse, Laura Beachy, Becky Brocato, Daniel Buckland, Jackie Charvat, Diana Cruz Topete, Quinn Dufurrena, Robert Haddon, Joanne Kaouk, Kim Lowe, Steve Laurie, Karina Marshall-Goebel, Sara Mason, Shannan Moynihan, James Pattarini, Devan Petersen, Ruth Reitzel, Donna Roberts, Lucia Roccaro, Mike Stenger, Terry Taddeo, Gavin Travers, Mary Van Baalen, Liz WarrenNASA In October 2024, NASA’s Office of the Chief Health and Medical Officer (OCHMO) initiated a working group to review the status and progress of research and clinical activities intended to mitigate the risk of venous thromboembolism (VTE) during spaceflight. The working group took place over two days at NASA’s Johnson Space Center; a second meeting on the topic was held in December 2024 at the European Space Agency (ESA) facility in Cologne, Germany.
Read More about the Risk of VTE The working group was assembled from internal NASA subject matter experts (SMEs), the NASA OCHMO Standards Team, NASA and ESA stakeholders, and external SMEs, including physicians and medical professionals from leading universities and medical centers in the United States and Canada.
Background
Spaceflight Venous Thrombosis (SVT)
Spaceflight Venous Thrombosis (SVT) refers to a phenomenon experienced during spaceflight in which a thrombus (blood clot) forms in the internal jugular vein (and/or associated vasculature) that may be symptomatic (thrombus accompanied by, but not limited to, visible internal jugular vein swelling, facial edema beyond “nominal” spaceflight adaptation, eyelid edema, and/or headache) or asymptomatic. Obstructive thrombi have been identified in a very small number of crewmembers, as shown in the figure below.
Note that the figure below is for illustrative purposes only; locations are approximate, and size is not to scale.
Approximate location of identified thrombi in crewmembers.Source: Modified from Cerebral Sinus Venous Thrombosis – University of Colorado Denver With treatment, crewmembers were able to complete their mission, and anticoagulants were discontinued several days prior to landing to minimize the risk of bleeding in the event of a traumatic injury. Some thromboses completely resolved post landing, and some required additional treatment.
Pathophysiology of Venous Thromboembolism (VTE)
The proposed pathogenesis of VTE is referred to as Virchow’s triad and suggests that VTE occurs as the result of:
Alterations in blood flow (i.e., stasis), Vascular endothelial injury/changes, and/or, Alterations in the constituents of the blood leading to hypercoagulability (i.e., hereditary predisposition or acquired hypercoagulability). Note: pathophysiology are the changes that occur during a disease process; hypercoagulability is the increased tendency to develop blood to clots.
The Virchow’s triad of risk factors for venous thrombosis.Bouchnita, 2017 Blood stasis, or venous stasis, refers to a condition in which the blood flow in the veins slows down which leads to pooling in the veins. This slowing of the blood may be due to vein valves becoming damaged or weak, immobility, and/or the absence of muscular contractions. Associated symptoms include swelling, skin changes, varicose veins, and slow-healing sores or ulcers. In terrestrial medicine, venous thrombosis is typically caused by damaged or weakened vein valves, which can be due to many factors, including aging, blood clots, varicose veins, obesity, pregnancy, sedentary lifestyle, estrogen use, and hereditary predisposition.
Spaceflight Considerations
Altered Venous Blood Flow and Spaceflight Associated Neuro-ocular Syndrome
In addition to the terrestrial risk factors of VTE, there are physiological changes associated with spaceflight that are hypothesized to potentially play a role in the development of VTE in weightlessness. Specifically, researchers have explored the effects of the microgravity environment and subsequent observed headward fluid shifts that occur, and the potential impact on blood flow. Crewmembers onboard the International Space Station (ISS) experience weightlessness due to the microgravity environment and thus experience a sustained redistribution of bodily fluids from the legs toward the head. The prolonged headward fluid shifts during weightlessness results in facial puffiness, decreased leg volume, increased cardiac stroke volume, and decreased plasma volume.
Crewmembers have also experienced altered blood flow during spaceflight, including retrograde venous blood flow (RVBF) (the backflow of venous blood towards the brain) or stasis (a stoppage or slowdown in the flow of blood). While the causes of the observed stasis and retrograde blood flow in spaceflight participants is not well understood, the potential clinical significance of the role it may have in the development of thrombus formation warrants further investigation.
Doppler imaging of a retrograde flow in the left internal jugular vein.Yan & Seow, 2009 Other physiological concerns affected by fluid shifts are being studied to consider if any relation to VTE exists. Chronic weightlessness can cause bodily fluids such as blood and cerebrospinal fluid to move toward the head, which can lead to optic nerve swelling, folds in the retina, flattening of the back of the eye, and swelling in the brain. This collection of eye and brain changes is called “spaceflight associated neuro-ocular syndrome,” or SANS. Some astronauts only experience mild changes in space, while others have clinically significant outcomes. The long-term health outcome from these changes is unknown but actively being investigated. The risk of developing SANS is higher during longer-duration missions and remains a top research priority for scientists ahead of a Mars mission.
Conclusions and Further Work
Based on expert opinion and the assessment of the risk factors for thrombosis, an algorithm was developed to provide guidance for in-mission assessment and treatment of thrombus formation in weightlessness. The algorithm is based on early in-flight ultrasound testing to determine the flow characteristic of the left internal jugular vein and associated vasculature.
NASA Working Group Recommendations
The working group recommended several areas for further investigation to assess feasibility and potential to mitigate the risk of thrombosis in spaceflight:
Improved detection capabilities to identify when a thrombus has formed in-flight, Pathophysiology/factors leading to thrombi formation during spaceflight, Countermeasures and treatment
For more information on the working group meeting and a complete list of references, please see the Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report.
Risk of Venous Thromboembolism (VTE) During Spaceflight Summary Report Share
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Last Updated Mar 14, 2025 EditorKim Lowe Related Terms
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By NASA
NICER (left) is shown mounted to the International Space Station, and LEXI (right) is shown attached to the top of Firefly Aerospace’s Blue Ghost in an artist’s rendering.NASA/Firefly Aerospace The International Space Station supports a wide range of scientific activities from looking out at our universe to breakthroughs in medical research, and is an active proving ground for technology for future Moon exploration missions and beyond. Firefly Aerospace’s Blue Ghost Mission-1 landed on the Moon on March 2, 2025, kicking off science and technology operations on the surface, including three experiments either tested on or enabled by space station research. These projects are helping scientists study space weather, navigation, and computer performance in space— knowledge crucial for future Moon missions.
One of the experiments, the Lunar Environment Heliospheric X-ray Imager (LEXI), is a small telescope designed to study the Earth’s magnetic environment and its interaction with the solar wind. Like the Neutron star Interior Composition Explorer (NICER) telescope mounted outside of the space station, LEXI observes X-ray sources. LEXI and NICER observed the same X-ray star to calibrate LEXI’s instrument and better analyze the X-rays emitted from Earth’s upper atmosphere, which is LEXI’s primary target. LEXI’s study of the interaction between the solar wind and Earth’s protective magnetosphere could help researchers develop methods to safeguard future space infrastructure and understand how this boundary responds to space weather.
Other researchers sent the Radiation Tolerant Computer System (RadPC) to the Moon to test how computers can recover from radiation-related faults. Before RadPC flew on Blue Ghost, researchers tested a radiation tolerant computer on the space station and developed an algorithm to detect potential hardware faults and prevent critical failures. RadPC aims to demonstrate computer resilience in the Moon’s radiation environment. The computer can gauge its own health in real time, and RadPC can identify a faulty location and repair it in the background as needed. Insights from this investigation could improve computer hardware for future deep-space missions.
In addition, the Lunar Global Navigation Satellite System (GNSS) Receiver Experiment (LuGRE) located on the lunar surface has officially received a GNSS signal at the farthest distance from Earth, the same signals that on Earth are used for navigation on everything from smartphones to airplanes. Aboard the International Space Station, Navigation and Communication Testbed (NAVCOM) has been testing a backup system to Earth’s GNSS using ground stations as an alternative method for lunar navigation where GNSS signals may have limitations. Bridging existing systems with emerging lunar-specific navigation solutions could help shape how spacecraft navigate the Moon on future missions.
The International Space Station serves as an important testbed for research conducted on missions like Blue Ghost and continues to lay the foundation for technologies of the future.
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