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By NASA
A host of scientific investigations await the crew of NASA’s SpaceX Crew-11 mission during their long-duration expedition aboard the International Space Station. NASA astronauts Zena Cardman and Mike Fincke, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui, are set to study plant cell division and microgravity’s effects on bacteria-killing viruses, as well as perform experiments to produce a higher volume of human stem cells and generate on-demand nutrients.
Here are details on some of the research scheduled during the Crew-11 mission:
Making more stem cells
Cultures of stem cells grown in 2D on Earth, left, and as 3D spheres in simulated microgravity on Earth.BioServe A stem cell investigation called StemCellEx-IP1 evaluates using microgravity to produce large numbers of induced pluripotent stem cells. Made by reprogramming skin or blood cells, these stem cells can transform into any type of cell in the body and are used in regenerative medicine therapies for many diseases. However, producing enough cells on the ground is a challenge.
Researchers plan to use the microgravity environment aboard the space station to demonstrate whether generating 1,000 times more cells is possible and whether these cells are of higher quality and better for clinical use than those made on Earth. If proven, this could significantly improve future patient outcomes.
“This type of stem cell research is a chance to find treatments and maybe even cures for diseases that currently have none,” said Tobias Niederwieser of BioServe Space Technologies, which developed the investigation. “This represents an incredible potential to make life here on Earth better for all of us. We can take skin or blood cells from a patient, convert them into stem cells, and produce custom cell-therapy with little risk for rejection, as they are the person’s own cells.”
Alternative to antibiotics
Genes in Space-12 student investigators Isabella Chuang, left, and Julia Gross, middle, with mentor Kayleigh Ingersoll Omdahl.Genes in Space Genes in Space is a series of competitions in which students in grades 7 through 12 design DNA experiments that are flown to the space station. Genes in Space-12 examines the effects of microgravity on interactions between certain bacteria and bacteriophages, which are viruses that infect and kill bacteria. Bacteriophages already are used to treat bacterial infections on Earth.
“Boeing and miniPCR bio co-founded this competition to bring real-world scientific experiences to the classroom and promote molecular biology investigations on the space station,” said Scott Copeland of Boeing, and co-founder of Genes in Space. “This
investigation could establish a foundation for using these viruses to treat bacterial infections in space, potentially decreasing the dependence on antibiotics.”
“Previous studies indicate that bacteria may display increased growth rates and virulence in space, while the antibiotics used to combat them may be less effective,” said Dr. Ally Huang, staff scientist at miniPCR bio. “Phages produced in space could have profound implications for human health, microbial control, and the sustainability of long-duration remote missions. Phage therapy tools also could revolutionize how we manage bacterial infections and microbial ecosystems on Earth.”
Edible organisms
A purple, pre-incubation BioNutrients-3 bag, left, and a pink bag, right, which has completed incubation, on a purple and pink board used for comparison.NASA Some vitamins and nutrients in foods and supplements lose their potency during prolonged storage, and insufficient intake of even a single nutrient can lead to serious diseases, such as a vitamin C deficiency, causing scurvy. The BioNutrients-3 experiment builds on previous investigations looking at ways to produce on-demand nutrients in space using genetically engineered organisms that remain viable for years. These include yogurt and a yeast-based beverage made from yeast strains previously tested aboard station, as well as a new, engineered co-culture that produces multiple nutrients in one sample bag.
“BioNutrients-3 includes multiple food safety features, including pasteurization to kill microorganisms in the sample and a demonstration of the feasibility of using a sensor called E-Nose that simulates an ultra-sensitive nose to detect pathogens,” said Kevin Sims, project manager at NASA’s Ames Research Center in California’s Silicon Valley.
Another food safety feature is a food-grade pH indicator to track bacterial growth.
“These pH indicators help the crew visualize the progress of the yogurt and kefir samples,” Sims said. “As the organisms grow, they generate lactic acid, which lowers the pH and turns the indicator pink.”
The research also features an investigation of yogurt passage, which seeds new cultures using a bit of yogurt from a finished bag, much like maintaining a sourdough bread starter. This method could sustain a culture over multiple generations, eliminating concerns about yogurt’s shelf life during a mission to the Moon or Mars while reducing launch mass.
Understanding cell division
Cells of green algae dividing.University of Toyama The JAXA Plant Cell Division investigation examines how microgravity affects cell division in green algae and a strain of cultured tobacco cells. Cell division is a fundamental element of plant growth, but few studies have examined it in microgravity.
“The tobacco cells divide frequently, making the process easy to observe,” said Junya Kirima of JAXA. “We are excited to reveal the effects of the space environment on plant cell division and look forward to performing time-lapse live imaging of it aboard the space station.”
Understanding this process could support the development of better methods for growing plants for food in space, including on the Moon and Mars. This investigation also could provide insight to help make plant production systems on Earth more efficient.
For nearly 25 years, people have lived and worked continuously aboard the International Space Station, advancing scientific knowledge and conducting critical research for the benefit of humanity and our home planet. Space station research supports the future of human spaceflight as NASA looks toward deep space missions to the Moon under the Artemis campaign and in preparation for future human missions to Mars, as well as expanding commercial opportunities in low Earth orbit and beyond.
Learn more about the International Space Station at:
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By NASA
Hydrocarbon lake and methane rain clouds on Titan Jenny McElligott/eMITS NASA research has shown that cell-like compartments called vesicles could form naturally in the lakes of Saturn’s moon Titan.
Titan is the only world apart from Earth that is known to have liquid on its surface. However, Titan’s lakes and seas are not filled with water. Instead, they contain liquid hydrocarbons like ethane and methane.
On Earth, liquid water is thought to have been essential for the origin of life as we know it. Many astrobiologists have wondered whether Titan’s liquids could also provide an environment for the formation of the molecules required for life – either as we know it or perhaps as we don’t know it – to take hold there.
New NASA research, published in the International Journal of Astrobiology, outlines a process by which stable vesicles might form on Titan, based on our current knowledge of the moon’s atmosphere and chemistry. The formation of such compartments is an important step in making the precursors of living cells (or protocells).
The process involves molecules called amphiphiles, which can self-organize into vesicles under the right conditions. On Earth, these polar molecules have two parts, a hydrophobic (water-fearing) end and a hydrophilic (water-loving) end. When they are in water, groups of these molecules can bunch together and form ball-like spheres, like soap bubbles, where the hydrophilic part of the molecule faces outward to interact with the water, thereby ‘protecting’ the hydrophobic part on the inside of the sphere. Under the right conditions, two layers can form creating a cell-like ball with a bilayer membrane that encapsulates a pocket of water on the inside.
When considering vesicle formation on Titan, however, the researchers had to take into account an environment vastly different from the early Earth.
Uncovering Conditions on Titan
Huygens captured this aerial view of Titan from an altitude of 33,000 feet. ESA/NASA/JPL/University of Arizona Titan is Saturn’s largest moon and the second largest in our solar system. Titan is also the only moon in our solar system with a substantial atmosphere.
The hazy, golden atmosphere of Titan kept the moon shrouded in mystery for much of human history. However, when NASA’s Cassini spacecraft arrived at Saturn in 2004, our views of Titan changed forever.
Thanks to Cassini, we now know Titan has a complex meteorological cycle that actively influences the surface today. Most of Titan’s atmosphere is nitrogen, but there is also a significant amount of methane (CH4). This methane forms clouds and rain, which falls to the surface to cause erosion and river channels, filling up the lakes and seas. This liquid then evaporates in sunlight to form clouds once again.
This atmospheric activity also allows for complex chemistry to happen. Energy from the Sun breaks apart molecules like methane, and the pieces then reform into complex organic molecules. Many astrobiologists believe that this chemistry could teach us how the molecules necessary for the origin of life formed and evolved on the early Earth.
Building Vesicles on Titan
The new study considered how vesicles might form in the freezing conditions of Titan’s hydrocarbon lakes and seas by focusing on sea-spray droplets, thrown upwards by splashing raindrops. On Titan, both spray droplets and the sea surface could be coated in layers of amphiphiles. If a droplet then lands on the surface of a pond, the two layers of amphiphiles meet to form a double-layered (or bilayer) vesicle, enclosing the original droplet. Over time, many of these vesicles would be dispersed throughout the pond and would interact and compete in an evolutionary process that could lead to primitive protocells.
If the proposed pathway is happening, it would increase our understanding of the conditions in which life might be able to form.
“The existence of any vesicles on Titan would demonstrate an increase in order and complexity, which are conditions necessary for the origin of life,” explains Conor Nixon of NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “We’re excited about these new ideas because they can open up new directions in Titan research and may change how we search for life on Titan in the future.”
NASA’s first mission to Titan is the upcoming Dragonfly rotorcraft, which will explore the surface of the Saturnian moon. While Titan’s lakes and seas are not a destination for Dragonfly (and the mission won’t carry the light-scattering instrument required to detect such vesicles), the mission will fly from location to location to study the moon’s surface composition, make atmospheric and geophysical measurements, and characterize the habitability of Titan’s environment.
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The Swept Wing Flow Test model, known as SWiFT, with pressure sensitive paint applied, sports a pink glow under ultraviolet lights while tested during 2023 in a NASA wind tunnel at Langley Research Center in Virginia.NASA / Dave Bowman Many of us grew up using paint-by-number sets to create beautiful color pictures.
For years now, NASA engineers studying aircraft and rocket designs in wind tunnels have flipped that childhood pastime, using computers to generate images from “numbers-by-paint” – pressure sensitive paint (PSP), that is.
Now, advances in the use of high-speed cameras, supercomputers, and even more sensitive PSP have made this numbers-by-paint process 10,000 times faster while creating engineering visuals with 1,000 times higher resolution.
So, what’s the big difference exactly between the “old” capability in use at NASA for more than a decade and the “new?”
“The key is found by adding a single word in front of PSP, namely ‘unsteady’ pressure sensitive paint, or uPSP,” said E. Lara Lash, an aerospace engineer from NASA’s Ames Research Center in California’s Silicon Valley.
With PSP, NASA researchers study the large-scale effects of relatively smooth air flowing over the wings and body of aircraft. Now with uPSP, they are able to see in finer detail what happens when more turbulent air is present – faster and better than ever before.
In some cases with the new capability, researchers can get their hands on the wind tunnel data they’re looking for within 20 minutes. That’s quick enough to allow engineers to adjust their testing in real time.
Usually, researchers record wind tunnel data and then take it back to their labs to decipher days or weeks later. If they find they need more data, it can take additional weeks or even months to wait in line for another turn in the wind tunnel.
“The result of these improvements provides a data product that is immediately useful to aerodynamic engineers, structural engineers, or engineers from other disciplines,” Lash said.
Robert Pearce, NASA’s associate administrator for aeronautics, who recently saw a demonstration of uPSP-generated data displayed at Ames, hailed the new tool as a national asset that will be available to researchers all over the country.
“It’s a unique NASA innovation that isn’t offered anywhere else,” Pearce said. “It will help us maintain NASA’s world leadership in wind tunnel capabilities.”
A technician sprays unsteady pressure sensitive paint onto the surface of a small model of the Space Launch System in preparation for testing in a NASA wind tunnel.NASA / Dave Bowman How it Works
With both PSP and uPSP, a unique paint is applied to scale models of aircraft or rockets, which are mounted in wind tunnels equipped with specific types of lights and cameras.
When illuminated during tests, the paint’s color brightness changes depending on the levels of pressure the model experiences as currents of air rush by. Darker shades mean higher pressure; lighter shades mean lower pressure.
Cameras capture the brightness intensity and a supercomputer turns that information into a set of numbers representing pressure values, which are made available to engineers to study and glean what truths they can about the vehicle design’s structural integrity.
“Aerodynamic forces can vibrate different parts of the vehicle to different degrees,” Lash said. “Vibrations could damage what the vehicle is carrying or can even lead to the vehicle tearing itself apart. The data we get through this process can help us prevent that.”
Traditionally, pressure readings are taken using sensors connected to little plastic tubes strung through a model’s interior and poking up through small holes in key places, such as along the surface of a wing or the fuselage.
Each point provides a single pressure reading. Engineers must use mathematical models to estimate the pressure values between the individual sensors.
With PSP, there is no need to estimate the numbers. Because the paint covers the entire model, its brightness as seen by the cameras reveals the pressure values over the whole surface.
A four-percent scale model of the Space Launch System rocket is tested in 2017 using unsteady Pressure Sensitive Paint inside the 11-foot by 11-foot Unitary Plan Wind Tunnel at NASA’s Ames Research Center in California.NASA / Dominic Hart Making it Better
The introduction, testing, and availability of uPSP is the result of a successful five-year-long effort, begun in 2019, in which researchers challenged themselves to significantly improve the PSP’s capability with its associated cameras and computers.
The NASA team’s desire was to develop and demonstrate a better process of acquiring, processing, and visualizing data using a properly equipped wind tunnel and supercomputer, then make the tool available at NASA wind tunnels across the country.
The focus during a capability challenge was on NASA’s Unitary Plan Facility’s 11-foot transonic wind tunnel, which the team connected to the nearby NASA Advanced Supercomputing Facility, both located at Ames.
Inside the wind tunnel, a scale model of NASA’s Space Launch System rocket served as the primary test subject during the challenge period.
Now that the agency has completed its Artemis I uncrewed lunar flight test mission, researchers can match the flight-recorded data with the wind tunnel data to see how well reality and predictions compare.
With the capability challenge officially completed at the end of 2024, the uPSP team is planning to deploy it to other wind tunnels and engage with potential users with interests in aeronautics or spaceflight.
“This is a NASA capability that we have, not only for use within the agency, but one that we can offer industry, academia, and other government agencies to come in and do research using these new tools,” Lash said.
NASA’s Aerosciences Evaluation and Test Capabilities portfolio office, an organization managed under the agency’s Aeronautics Research Mission Directorate, oversaw the development of the uPSP capability.
Watch this uPSP Video
About the Author
Jim Banke
Managing Editor/Senior WriterJim Banke is a veteran aviation and aerospace communicator with more than 40 years of experience as a writer, producer, consultant, and project manager based at Cape Canaveral, Florida. He is part of NASA Aeronautics' Strategic Communications Team and is Managing Editor for the Aeronautics topic on the NASA website.
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Last Updated Jul 03, 2025 EditorJim BankeContactJim Bankejim.banke@nasa.gov Related Terms
Aeronautics Aeronautics Research Mission Directorate Aerosciences Evaluation Test Capabilities Ames Research Center Flight Innovation Glenn Research Center Langley Research Center Transformational Tools Technologies
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By NASA
The book cover for the 2025 edition of the Microgravity Materials Research Researcher’s Guide June 2025 Edition
Most materials are formed from a partially or totally fluid sample, and the transport of heat and mass from the fluid into the solid during solidification inherently influences the formation of the material and its resultant properties. The ISS provides a long-duration microgravity environment for conducting experiments that enables researchers to examine the effects of heat and mass transport on materials processes in the near-absence of gravity-driven forces. The microgravity environment greatly reduces buoyancy-driven convection, hydrostatic pressure, and sedimentation. It can also be advantageous for designing experiments with reduced container interactions. The reduction in these gravity-related sources of heat and mass transport may be taken advantage of to determine how material processes and microstructure formation are affected by gravity-driven and gravity independent sources of heat and mass transfer.
Materials science experiments on the ISS have yielded broad and significant scientific advancements, including contributing to the development of improved mathematical models for predicting material properties during processing on Earth and enabling a better understanding of microstructure formation during solidification towards controlling the material properties of various alloys.
This researcher’s guide provides information on the acceleration environment of the space station and describes facilities available for materials research. Examples of previous microgravity materials research and descriptions of planned research are also provided.
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By Space Force
Vandenberg Space Force Base stands as a vital hub where Guardians and Airmen oversee launches that safeguard U.S. interests and uphold America’s edge in the space domain.
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