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By NASA
Bone cellsNASA Malcolm O’Malley and his mom sat nervously in the doctor’s office awaiting the results of his bloodwork. This was no ordinary check-up. In fact, this appointment was more urgent and important than the SATs the seventeen-year-old, college hopeful had spent months preparing for and was now missing in order to understand his symptoms.
But when the doctor shared the results – he had off-the-charts levels of antibodies making him deathly allergic to shellfish – O’Malley realized he had more questions than answers. Like: Why is my immune system doing this? How is it working? Why is it reacting so severely and so suddenly (he’d enjoyed shrimp less than a year ago)? And why does the only treatment – an injection of epinephrine – have nothing to do with the immune system, when allergies appear to be an immune system problem? Years later, O’Malley would look to answer some of these questions while interning in the Space Biosciences Research Branch at NASA’s Ames Research Center in California’s Silicon Valley.
“Anaphylaxis is super deadly and the only treatment for it is epinephrine; and I remember thinking, ‘how is this the best we have?’ because epinephrine does not actually treat the immune system at all – it’s just adrenaline,” said O’Malley, who recently returned to his studies as a Ph.D. student of Biomedical Engineering at the University of Virginia (UVA) in Charlottesville. “And there’s a thousand side effects, like heart attacks and stroke – I remember thinking ‘these are worse than the allergy!’”
O’Malley’s curiosity and desire to better understand the mechanisms and connections between what triggers different immune system reactions combined with his interest in integrating datasets into biological insights inspired him to shift his major from computer science to biomedical engineering as an undergraduate student. With his recent allergy diagnosis and a lifelong connection to his aunt who worked at the UVA Heart and Vascular Center, O’Malley began to build a bridge between the immune system and heart health. By the time he was a senior in college, he had joined the Cardiac Systems Biology Lab, and had chosen to focus his capstone project on better understanding the role of neutrophils, a specific type of immune cell making up 50 to 70% of the immune system, that are involved in cardiac inflammation in high blood pressure and after heart attacks.
jsc2022e083018 (10/26/2022) — A preflight image of beating cardiac spheroid composed of iPSC-derived cardiomyocytes (CMs), endothelial cells (ECs), and cardiac fibroblasts (CFs). These cells are incubated and put under the microscope in space as part of the Effect of Microgravity on Drug Responses Using Heart Organoids (Cardinal Heart 2.0) investigation. Image courtesy of Drs. Joseph Wu, Dilip Thomas and Xu Cao, Stanford Cardiovascular Institute “The immune system is involved in everything,” O’Malley says. “Anytime there’s an injury – a paper cut, a heart attack, you’re sick – the immune system is going to be the first to respond; and neutrophils are the first responders.”
O’Malley’s work to determine what regulates the immune system’s interrelated responses – like how one cell could affect other cells or immune processes downstream – provided a unique opportunity for him to support multiple interdisciplinary NASA biological and physical sciences research projects during his 10-week internship at NASA Ames over the summer of 2024. O’Malley applied machine learning techniques to the large datasets the researchers were using from experiments and specimens collected over many years to help identify possible causes of inflammation seen in the heart, brain, and blood, as well as changes seen in bones, metabolism, the immune system, and more when humans or other model organisms are exposed to decreased gravity, social isolation, and increased radiation. These areas are of keen interest to NASA due to the risks to human health inherent in space exploration and the agency’s plans to send humans on long-duration missions to the Moon, Mars, and beyond.
“It’s exciting that we just never know what’s going to happen, how the immune system is going to react until it’s already been activated or challenged in some way,” said O’Malley. “I’m particularly interested in the adaptive immune system because it’s always evolving to meet new challenges; whether it’s a pandemic-level virus, bacteria or something on a mission to Mars, our bodies are going to have some kind of adaptive immune response.”
During his NASA internship, O’Malley applied a statistical analysis techniques to plot and make more sense of the massive amounts of life sciences data. From there, researchers could find out which proteins, out of hundreds, or attributes – like differences in sex – are related to which behaviors or outcomes. For example, through O’Malley’s analysis, researchers were able to better pinpoint the proteins involved in inflammation of the brain that may play a protective role in spatial memory and motor control during and after exposure to radiation – and how we might be able to prevent or mitigate those impacts during future space missions and even here on Earth.
As someone who’s both black and white, representation is important to me. It’s inspiring to think there will be people like me on the Moon – and that I’m playing a role in making this happen
Malcolm o'malley
Former NASA Intern
“I had this moment where I realized that since my internship supports NASA’s Human Research Program that means the work I’m doing directly applies to Artemis, which is sending the first woman and person of color to the Moon,” reflected O’Malley. “As someone who’s both black and white, representation is important to me. It’s inspiring to think there will be people like me on the Moon – and that I’m playing a role in making this happen.”
Artist conception of a future Artemis Base Camp on the lunar surface NASA When O’Malley wasn’t exploring the mysteries of the immune system for the benefit of all at NASA Ames, he taught himself how to ride a bike and started to surf in the nearby waters of the Pacific Ocean. O’Malley considers Palmyra, Virginia, his hometown and he enjoys playing sports – especially volleyball, water polo, and tennis – reading science fiction and giving guest lectures to local high school students hoping to spark their curiosity.
O’Malley’s vision for the future of biomedical engineering reflects his passion for innovation. “I believe that by harnessing the unique immune properties of other species, we can achieve groundbreaking advancements in limb regeneration, revolutionize cancer therapy, and develop potent antimicrobials that are considered science fiction today,” he said.
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By Space Force
The U.S. Space Force and Canadian Armed Forces have kicked off an Operations and Sustainment Phase which will provide Canada with six years of access to the Space Force’s Mobile User Objective System Satellite System.
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By NASA
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By European Space Agency
The Copernicus Sentinel Expansion Missions are a major leap forward in Europe’s Earth observation capabilities. With the United Kingdom’s re-entry to the EU’s Copernicus programme, funding has been confirmed to complete the development of all six Copernicus Sentinel Expansion Missions, as discussed this week during the International Astronautical Congress taking place in Milan, Italy.
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
Water piping is installed near the Thad Cochran Test Stand (B-1/B-2) at NASA’s Stennis Space Center in December 2014. The project to replace and upgrade the center’s high pressure industrial water system was a key milestone in preparations to test the SLS (Space Launch System) core stage ahead of the successful Artemis I launch.NASA/Danny Nowlin Employees install a 96-inch valve near the Thad Cochran Test Stand (B-1/B-2) at NASA’s Stennis Space Center as part of a high-pressure industrial water upgrade project in March 2015.NASA/Danny Nowlin In this March 2022 photo, crews use a shoring system to hold back soil as they install new 75-inch piping leading from the NASA Stennis High Pressure Industrial Water Facility to the valve vault pit serving the Fred Haise Test Stand.NASA/Danny Nowlin Crews use a specially designed tool to place a new pipeline liner inside the existing carrier pipe near the Fred Haise Test Stand in 2024 in the last phase of updating the original test complex industrial water system at NASA’s Stennis Space Center.NASA/Danny Nowlin Crews prepare new pipeline liner sections for installation near the Fred Haise Test Stand in 2024 in the last phase of updating the original test complex industrial water system at NASA’s Stennis Space Center.NASA/Danny Nowlin For almost 60 years, NASA’s Stennis Space Center has tested rocket systems and engines to help power the nation’s human space exploration dreams. Completion of a critical water system infrastructure project helps ensure the site can continue that frontline work moving forward.
“The infrastructure at NASA Stennis is absolutely critical for rocket engine testing for the agency and commercial companies,” said NASA project manager Casey Wheeler. “Without our high pressure industrial water system, testing does not happen. Installing new underground piping renews the lifespan and gives the center a system that can be operated for the foreseeable future, so NASA Stennis can add to its nearly six decades of contributions to space exploration efforts.”
The high pressure industrial water system delivers hundreds of thousands of gallons of water per minute through underground pipes to cool rocket engine exhaust and provide fire suppression capabilities during testing. Without the water flow, the engine exhaust, reaching as hot as 6,000 degrees Fahrenheit, could melt the test stand’s steel flame deflector.
Each test stand also features a FIREX system that holds water in reserve for use in the event of a mishap or fire. During SLS (Space Launch System) core stage testing, water also was used to create a “curtain” around the test hardware, dampening the high levels of noise generated during hot fire and lessening the video-acoustic impact that can cause damage to infrastructure and the test hardware.
Prior to the system upgrade, the water flow was delivered by the site’s original piping infrastructure built in the 1960s. However, that infrastructure had well exceeded its expected 30-year lifespan.
Scope of the Project
The subsequent water system upgrade was planned across multiple phases over a 10-year span. Crews worked around ever-changing test schedules to complete three major projects representing more than $50 million in infrastructure investment.
“Many people working the construction jobs for these projects are from the Gulf Coast area, so it has created jobs and work for the people doing the construction,” Wheeler said. “Some of the specialty work has had people coming in from all over the country, as well as vendors and suppliers that are supplying the materials, so that has an economic impact here too.”
Crews started by replacing large sections of piping, including a 96-inch line, from the 66-million-gallon onsite reservoir to the Thad Cochran (B-1/B-2) Test Stand. This phase also included the installation of a new 25,000-gallon electric pump at the High Pressure Industrial Water Facility to increase water flow capacity. The upgrades were critical for NASA Stennis to conduct Green Run testing of the SLS core stage in 2020-21 ahead of the successful Artemis I launch.
Work in the A Test Complex followed with crews replacing sections of 75-inch piping from the water plant and installing several new 66-inch gate valves.
In the final phase, crews used an innovative approach to install new steel liners within existing pipes leading to the Fred Haise Test Stand (formerly A-1 Test Stand). The work followed NASA’s completion of a successful RS-25 engine test campaign last April for future Artemis missions to the Moon and beyond. The stand now is being prepared to begin testing of new RS-25 flight engines.
Overall, the piping project represents a significant upgrade in design and materials. The new piping is made from carbon steel, with protective linings to prevent corrosion and gate valves designed to be more durable.
Importance of Water
It is hard to overstate the importance of the work to ensure ongoing water flow. For a typical 500-second RS-25 engine test on the Fred Haise Test Stand, around 5 million gallons of water is delivered from the NASA Stennis reservoir through a quarter-of-a-mile of pipe before entering the stand to supply the deflector and cool engine exhaust.
“Without water to cool the deflector and the critical parts of the test stand that will get hot from the hot fire itself, the test stand would need frequent corrective maintenance,” Wheeler said. “This system ensures the test stands remain in a condition where continuous testing can happen.”
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Last Updated Sep 26, 2024 EditorNASA Stennis CommunicationsContactC. Lacy Thompsoncalvin.l.thompson@nasa.gov / (228) 688-3333LocationStennis Space Center Related Terms
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